Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jean-Jacques Perie"'
Publikováno v:
Journal of Physical Organic Chemistry. 11:793-802
Compounds similar in structure to reactants, intermediates and products of the aldolase-catalysed reaction were synthesized and their affinities for the enzyme determined. The best situations were found with β-dicarbonyl phosphorylated compounds whi
Autor:
P. De Macedo Puyau, Jean-Jacques Perie
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 129:13-45
Several substrate analogues of the title enzyme were synthesized as well as with possible irreversible inhibitors, analogues of phosphoglycolate, the cofactor for this enzyme. The main routes involved an Arbuzov type reaction on functionalized halide
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:2043-2054
Various dihydroxyacetone-phosphate (DHAP) analogues bearing an aromatic ring or beta-dicarbonyl structures were synthesized. Their capacity to form a stabilized iminium ion or conjugated enamine in the reaction catalyzed by rabbit muscle aldolase (EC
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:1247-1253
A series of dihydroxyacetone-phosphate (DHAP) analogues has been synthesized, differing in their stereochemistry and functionality at C-3. The kinetic effects of these compounds on the enzyme aldolase (EC 4.1.2.13) have been studied and differing mod
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 76:155-158
Kinetic inhibition studies of the title enzyme by substrate analogues bearing reactive groups, epoxyde or α-enone, indicate that the substituents on the phosphorus atom play a crucial role in the efficiency of these inhibitors. This result is accoun
Publikováno v:
Enzyme and Microbial Technology. 13:19-23
A large-scale synthesis of glycerol 1-phosphate (75 g 1−1; 41%) has been developed using alkaline phosphatase immobilized on corn grits in reverse hydrolysis conditions. The reaction is highly regioselective at position 1 on glycerol but leads to a
Publikováno v:
European Journal of Medicinal Chemistry. 25:549-555
Carboxylated and phosphorylated esters of glycerol, possible inhibitors of the atypical glycolysis in trypanosomes have been synthesised and tested on Trypanosoma equiperdum in vitro and Trypanosoma brucei , on mice, and some of them also on glycerol
Autor:
Marc Poirot, Alain Klaebe, Frederic Delarue, Jean-Charles Faye, Philippe de Medina, Jean-Jacques Perie
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2000, 8, pp.2007-16
Bioorganic and Medicinal Chemistry, 2000, 8, pp.2007-16
Bioorganic and Medicinal Chemistry, Elsevier, 2000, 8, pp.2007-16
Bioorganic and Medicinal Chemistry, 2000, 8, pp.2007-16
New compounds have been synthesized based on the structure of the anti-tumoral drug tamoxifen and its diphenylmethane derivative, N,N-diethyl-2-[(4-phenyl-methyl)-phenoxy]-ethanamine, HCl (DPPE). These new compounds have no affinity for the estrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70090f9ae7cab0dbf6b564b9cce59183
https://www.hal.inserm.fr/inserm-00090778
https://www.hal.inserm.fr/inserm-00090778
Publikováno v:
Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology, 1993, 58, pp.311-6
Molecular and Biochemical Parasitology, 1993, 58, pp.311-6
A new family of benzyl-phenoxy-ethanamine derivatives has been assayed for trypanocidal activity. Using tritiated morpholino-benzyl-phenoxy-ethanamine as a probe, it is shown that this ligand is able to bind specifically to a protein contained in ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daff3fc1c9aac0c7208f302b5d3abaa9
https://www.hal.inserm.fr/inserm-00090796
https://www.hal.inserm.fr/inserm-00090796
Publikováno v:
Tetrahedron Letters. 24:3067-3070
Base catalysed hydrolysis of allophanic esters-models of carboxybiotine- in acetonitrile/water mixture, shows a sharp increase in rate constant in the range of 0.1–0.3 M in water, with a maximum which is interpreted as a balance between two desolva