Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jean-Jacques Godfroid"'
Autor:
Nadia Meddad-Bel Habich, Jean-Edouard Ombetta, Aazdine Lamouri, Françoise Heymans, Léon Assogba, Azali Ahamada-Himidi, Chang-Zhi Dong, Jean-Jacques Godfroid, Darina Aoun, Jack Huet, Latifa Boukli, Carine Mounier
Publikováno v:
European Journal of Medicinal Chemistry. 40:850-861
Starting from 4-tetradecyloxybenzamidine ( PMS815 ), a non-specific inhibitor of GI and GII PLA 2 s, we report in this work the discovery of the specificity through design, synthesis and structure–activity relationships studies of different kinds o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344bd152866c9acc1617d8c4905d47c3
https://doi.org/10.1016/j.ejmech.2005.03.027
https://doi.org/10.1016/j.ejmech.2005.03.027
Autor:
Stéphanie Plocki, Darina Aoun, Azali Ahamada-Himidi, Fernanda Tavarès-Camarinha, Chang-Zhi Dong, France Massicot, Jack Huet, Sylvie Adolphe-Pierre, François Chau, Jean-Jacques Godfroid, Nohad Gresh, Jean Edouard Ombetta, Françoise Heymans
Publikováno v:
European Journal of Organic Chemistry. 2005:2747-2757
3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062 or I) can probably act as a PLA2-II inhibitor on the acute inflammation model, but its highly lipophilic character could prevent it from being biodistributed effectively. In this work, based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2907849bd2cff3ea49fcf945e4a99b0d
https://doi.org/10.1002/ejoc.200400541
https://doi.org/10.1002/ejoc.200400541
Publikováno v:
European Journal of Organic Chemistry. 2000:2991-3000
The total synthesis of leukotrienes has been achieved starting from butadiene by a palladium-catalyzed telomerization at room temperature. A Sharpless catalytic asymmetric epoxidation generated the asymmetric centers with >94% ee. Simple transformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7c986811f8e94017152ac3206b23cf5
https://doi.org/10.1002/1099-0690(200009)2000:17<2991::aid-ejoc2991>3.0.co
https://doi.org/10.1002/1099-0690(200009)2000:17<2991::aid-ejoc2991>3.0.co
Autor:
Jack Huet, Marc Martin, Okkacha Bensaid, Erwan Kan, Dominique Dormont, Nathalie Dereuddre-Bosquet, Catherine Redeuilh, Nawal Serradji, Chang-Zhi Dong, Aazdine Lamouri, Pascal Clayette, Jean-Jacques Godfroid, Françoise Heymans
Publikováno v:
Journal of Medicinal Chemistry. 43:2149-2154
Excessive levels of PAF and cells of macrophage lineage appear to play an important role in neuronal cell injury, inflammatory syndrome, and HIV replication in CNS resulting in AIDS dementia complex (ADC). The beneficial effects of PAF receptor antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcb0491e61c3858ec4aa5f891a0f74f
https://doi.org/10.1021/jm9911276
https://doi.org/10.1021/jm9911276
Autor:
Dominique Bataille, Dominique Manechez, Laurence Le Brigand, Anne Virsolvy, Jean-Jacques Godfroid, Frances M. Ashcroft, Fiona M. Gribble, Beatrice Guardiola-Lemaitre
Publikováno v:
British Journal of Pharmacology. 128:1021-1026
The MIN6 cell line derived from in vivo immortalized insulin-secreting pancreatic β cells was used to study the insulin-releasing capacity and the cellular mode of action of S-22068, a newly synthesized imidazoline compound known for its antidiabeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25cb4ff1a03888631386e26f184c318e
https://doi.org/10.1038/sj.bjp.0702883
https://doi.org/10.1038/sj.bjp.0702883
Publikováno v:
European Journal of Organic Chemistry. 1999:2655-2662
An asymmetric total synthesis of Prostaglandin E1 (5) has been achieved in a two-component coupling process. The chiral hydroxycyclopentenone 6 was readily available from furan with 96% ee. The key reaction step was a kinetic enzymatic resolution fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b30b91051d5eac694198e795b39f90fa
https://doi.org/10.1002/(sici)1099-0690(199910)1999:10<2655::aid-ejoc2655>3.0.co
https://doi.org/10.1002/(sici)1099-0690(199910)1999:10<2655::aid-ejoc2655>3.0.co
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 42:843-850
Misoprostol-d3 (15) and its major plasma metabolite misoprostol free acid-d3 (5) were synthesized starting from commercially available methyl-d3-magnesium iodide. Copyright © 1999 John Wiley & Sons, Ltd.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e7c2af1175ac4024634b4ab134624af
https://doi.org/10.1002/(sici)1099-1344(199909)42:9<843::aid-jlcr246>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199909)42:9<843::aid-jlcr246>3.0.co
Autor:
P. Renard, Jean Jacques Godfroid, J. Huet, B. Pfeiffer, A. Lamouri, X. Wang, S. Lidy, D. Manechez, G. Le Bihan, E. Touboul, Alain Ktorza, Georges Dive, Luc Pénicaud, F. Rondu, A. Pele-Tounian, B. Guardiola-Lemaitre
Publikováno v:
Journal of Medicinal Chemistry. 42:1587-1603
Piperazine derivatives have been identified as new antidiabetic compounds. Structure-activity relationship studies in a series of 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines resulted in the identification of 1-methyl-4-(2', 4'-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3c815192f00968ba523531c25642df
https://doi.org/10.1021/jm981099b
https://doi.org/10.1021/jm981099b
Publikováno v:
Archiv der Pharmazie. 331:279-282
The first stereoselective synthesis of the specific EP 1 receptor agonist, 16,16-dimethyl prostaglandin E 2 1, is described. The key intermediate 3 was obtained from the E-allyl alcohol 6 via Sharpless epoxidation followed by stereospecific transform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1521bffc0a7597e2932b23f72f7eda68
https://doi.org/10.1002/(sici)1521-4184(19989)331:9<279::aid-ardp279>3.0.co
https://doi.org/10.1002/(sici)1521-4184(19989)331:9<279::aid-ardp279>3.0.co
Autor:
Xuan Wang, Agnès Pelé-Tounian, Bruno Pfeiffer, Sylvie Marc, Frédéric Rondu, Alain Ktorza, Beatrice Guardiola-Lemaitre, Luc Pénicaud, Dominique Manechez, Pierre Renard, Azzdine Lamouri, Estera Touboul, Raymond Dokhan, Jean-Jacques Godfroid
Publikováno v:
British Journal of Pharmacology. 124:1591-1596
Recent data suggest that some imidazoline derivatives can lower plasma glucose in experimental animal models of diabetes. We studied the activity of an imidazoline S-22068, in rat model of non-insulin-dependent diabetes mellitus (NIDDM) produced with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568f620ef306c5d628fc658728cdd25a
https://doi.org/10.1038/sj.bjp.0701989
https://doi.org/10.1038/sj.bjp.0701989