Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jean-Jacques Déglon"'
Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment
Autor:
Isabelle Gothuey, Hardy Hüttemann, Jacques Besson, Marina Croquette‐Krokkar, Pierre Baumann, Robert Hämmig, Séverine Crettol, Chin B. Eap, Jean-Jacques Déglon, Martine Monnat
Publikováno v:
Clinical Pharmacology & Therapeutics. 78:593-604
Background and Objective Recent in vitro studies have suggested an important role of cytochrome P450 (CYP) 2B6 and CYP2C19 in methadone metabolism. We aimed to determine the influence of CYP2B6, CYP2C9, and CYP2C19 genetic polymorphism on methadone p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0471ad56c53aebc6e65e877986eea8bc
https://doi.org/10.1016/j.clpt.2005.08.011
https://doi.org/10.1016/j.clpt.2005.08.011
Autor:
Rudolf Stohler, Doris Waldvogel, Santino Livoti, Sylvie Petitjean, Jean-Jacques Déglon, Dieter Ladewig, Claude Uehlinger
Publikováno v:
Drug and Alcohol Dependence. 62:97-104
This study compared the safety and efficacy of sublingual buprenorphine tablets with oral methadone in a population of opioid-dependent individuals in a double-blind, randomized, 6-week trial using a flexible dosing procedure. Fifty-eight patients se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753d24f9f738d95b913b1e21aa7001b5
https://doi.org/10.1016/s0376-8716(00)00163-0
https://doi.org/10.1016/s0376-8716(00)00163-0
Autor:
Jacques Spagnoli, K. Powell, Jean-Jacques Déglon, Chin B. Eap, Michel Bourquin, Santino Livoti, Pierre Baumann, Jean-Louis Martin
Publikováno v:
Drug and Alcohol Dependence. 61:47-54
Methadone is a 50:50 mixture of two enantiomers and (R)-methadone accounts for the majority of its opioid effect. The aim of this study was to determine whether a blood concentration of (R)-methadone can be associated with therapeutic response in add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461a51fd108646639f3c7161a4aa041f
https://doi.org/10.1016/s0376-8716(00)00121-6
https://doi.org/10.1016/s0376-8716(00)00121-6
Autor:
Jean-Jacques Déglon, Sylvie Petitjean, Santino Livoti, Doris Waldvogel, Dieter Ladewig, Claude Uehlinger
Publikováno v:
European Addiction Research. 4:13-18
A three-centre, randomised, double-blind study was designed to compare the efficacy and safety of buprenorphine and methadone. This was the first European study to compare these agents and was based on a previous trial performed in the US. Opioid-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff189e1206f4472e53e5c05ebae5560
https://doi.org/10.1159/000052036
https://doi.org/10.1159/000052036
Autor:
Séverine Crettol, Michel Bourquin, Jean-Jacques Déglon, Nicolas Ansermot, Jürg Schläpfer, Mohamed Faouzi, Norbert Scherbaum, Marina Croquette-Krokar, Chin B. Eap, Özgür Albayrak
Publikováno v:
Scopus-Elsevier
Background Methadone is administered as a chiral mixture of (R,S)- methadone. The opioid effect is mainly mediated by (R) -methadone, whereas (S) -methadone blocks the human ether-a-go-go–related gene (hERG) voltage-gated potassium channel more pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20809592efc3ec3f6e0163e3ea30393f
https://www.ncbi.nlm.nih.gov/pubmed/20308640
https://www.ncbi.nlm.nih.gov/pubmed/20308640
Autor:
John Attia, Jean-Jacques Déglon, Jacques Besson, Kingsley E Agho, John Ray, Séverine Crettol, Robert Hämmig, Andrew Byrne, Chin B. Eap, Marina Croquette-Krokar, Richard Hallinan, Andrew A. Somogyi
Publikováno v:
Hallinan, R; Crettol, S; Agho, K; Attia, J; Besson, J; Croquette-Krokar, M; Hämmig, R; Déglon, J.J.; Byrne, A; Ray, J; Somogyi, A.A.; Eap, C.B. (2009). Cannabis and benzodiazepines as determinants of methadone trough plasma concentration variability in maintenance treatment: a transnational study. European journal of clinical pharmacology, 65(11), pp. 1113-1120. Berlin: Springer 10.1007/s00228-009-0706-8
European Journal of Clinical Pharmacology, vol. 65, no. 11, pp. 1113-1120
European Journal of Clinical Pharmacology, Vol. 65, No 11 (2009) pp. 1113-20
European Journal of Clinical Pharmacology, vol. 65, no. 11, pp. 1113-1120
European Journal of Clinical Pharmacology, Vol. 65, No 11 (2009) pp. 1113-20
PURPOSE: To assess tobacco, alcohol, cannabis and benzodiazepine use in methadone maintenance treatment (MMT) as potential sources of variability in methadone pharmacokinetics. METHODS: Trough plasma (R)- and (S)-methadone concentrations were measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5634d417ab0d712b7c1afbc6b088612b
Publikováno v:
The Journal of Infectious Diseases, Vol. 164, No 5 (1991) pp. 965-968
It has been reported that human immunodeficiency virus type 1 (HIV-1) infection may exist in persons without specific antibodies for years. To measure the frequency of a silent carrier state, a study was conducted in a cohort of 124 intravenous drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e46dde6acf12bb721ec88acb3034e9
https://doi.org/10.1093/infdis/164.5.965
https://doi.org/10.1093/infdis/164.5.965
Autor:
Hugues Abriel, Jürg Schläpfer, L. Sintra Grilo, Séverine Crettol, Jean-Sébastien Rougier, Jean-Jacques Déglon, Pierre-Alain Carrupt, Jacques Besson, Chin B. Eap, Marina Croquette-Krokar
Publikováno v:
Pharmacopsychiatry, Vol. 41 (2008) pp. 207-208
Methadone inhibits the cardiac potassium channel hERG and can cause a prolonged QT interval. Methadone is chiral but its therapeutic activity is mainly due to (R)-methadone. Whole-cell patch-clamp experiments using cells expressing hERG showed that (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23bb0840b76438cb52120f06cb91fec
https://archive-ouverte.unige.ch/unige:4087
https://archive-ouverte.unige.ch/unige:4087
Autor:
Victor Gabriel, Bernard Hirschel, Claude-François Robert, Jean-Jacques Déglon, Luc Perrin, Joëlle Wintsch, Michel Bourquin, Jean-Louis Martin
Publikováno v:
AIDS, Vol. 4, No 7 (1990) pp. 657-660
In the early 1980s, more than 90% of intravenous drug users (IVDUs) shared needles and syringes in Geneva. The prevalence of antibodies to HIV in the sera of outpatient IVDUs increased from 6% in 1981 to 38% in 1983; it was, however, still only 37% i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420df1a7f68dd12f88743fa9c723b03c
https://doi.org/10.1097/00002030-199007000-00008
https://doi.org/10.1097/00002030-199007000-00008
Autor:
Jacques Besson, Martine Monnat, Marina Croquette-Krokar, Séverine Crettol, Martin Preisig, Robert Hämmig, Isabelle Gothuey, Jean-Jacques Déglon, Chin B. Eap
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 32(7)
Background Genetic variations of the dopamine and opioid receptors could influence the response to methadone maintenance treatment (MMT). Methods We included 238 MMT patients according to their response to treatment and methadone dosing, along with 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd5a05fb2a4a85ce6215a7897194d68
https://pubmed.ncbi.nlm.nih.gov/18687376
https://pubmed.ncbi.nlm.nih.gov/18687376