Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jean-Hugues Guervilly"'
Autor:
Elena Martínez-Balsalobre, Jean-Hugues Guervilly, Jenny van Asbeck-van der Wijst, Ana Belén Pérez-Oliva, Christophe Lachaud
Publikováno v:
Blood Reviews. :101094
Autor:
Michela Esposito, Pauline Rimmelé, Christel Guillouf, Maya Ridinger-Saison, Emmanuelle Despras, Françoise Moreau-Gachelin, Jean-Hugues Guervilly, Laure Delestré, Filippo Rosselli
Publikováno v:
Oncotarget
Oncotarget, 2017, 8 (23), ⟨10.18632/oncotarget.16183⟩
Oncotarget, Impact journals, 2017, 8 (23), ⟨10.18632/oncotarget.16183⟩
Oncotarget, 2017, 8 (23), ⟨10.18632/oncotarget.16183⟩
Oncotarget, Impact journals, 2017, 8 (23), ⟨10.18632/oncotarget.16183⟩
Oncogenes trigger replicative stress that can lead to genetic instability, which participates in cancer progression. Thus, determining how cells cope with replicative stress can help our understanding of oncogenesis and lead to the identification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31575dc6970580721b958d79903bd714
https://hal.science/hal-02424493
https://hal.science/hal-02424493
Publikováno v:
Human Molecular Genetics
The maintenance of genetic stability depends on the fine-tuned initiation and termination of pathways involved in cell cycle checkpoints and DNA repair. Here, we describe a new pathway that regulates checkpoint kinase 1 (CHK1) activity, a key element
Publikováno v:
Pathologie Biologie. 55:19-28
Fanconi anemia (FA) is a recessive human cancer prone syndrome featuring bone marrow failure, developmental abnormalities and hypersensitivity to DNA crosslinking agents exposure. 11 among 12 FA gene have been isolated. The biochemical functions of t
The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability
Autor:
Charly Chawhan, Emmanuelle Despras, Yoann Lovera, Filippo Rosselli, Arato Takedachi, Pierre-Henri L. Gaillard, Patricia Kannouche, Sarah Scaglione, Jean-Hugues Guervilly, Isao Kuraoka, Valeria Naim
Publikováno v:
Molecular Cell
Molecular Cell, 2015, 57 (1), pp.123-137. ⟨10.1016/j.molcel.2014.11.014⟩
Molecular Cell, Elsevier, 2015, 57 (1), pp.123-137. ⟨10.1016/j.molcel.2014.11.014⟩
Molecular Cell, 2015, 57 (1), pp.123-137. ⟨10.1016/j.molcel.2014.11.014⟩
Molecular Cell, Elsevier, 2015, 57 (1), pp.123-137. ⟨10.1016/j.molcel.2014.11.014⟩
International audience; The SLX4 Fanconi anemia protein is a tumor suppres- sor that may act as a key regulator that engages the cell into specific genome maintenance pathways. Here, we show that the SLX4 complex is a SUMO E3 ligase that SUMOylates S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd0574c25aea1f79dc9690ad04511c2
https://hal-amu.archives-ouvertes.fr/hal-01429041/document
https://hal-amu.archives-ouvertes.fr/hal-01429041/document
Publikováno v:
Journal of cell science. 127(Pt 16)
The aim of this study was to identify novel substrates of the FANCcore complex, which inactivation leads to the genetic disorder Fanconi anemia (FA), which associates bone marrow failure, developmental abnormalities and predisposition to cancer. Eigh
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2008, 17 (5), pp.679-89. ⟨10.1093/hmg/ddm340⟩
Human Molecular Genetics, Oxford University Press (OUP), 2008, 17 (5), pp.679-89. ⟨10.1093/hmg/ddm340⟩
Fanconi anemia (FA) is a cancer-prone hereditary disease resulting from mutations in one of the 13 genes defining the FANC/BRCA pathway. This pathway is involved in the cellular resistance to DNA-cross-linking agents. How the FANC/BRCA pathway is act
Publikováno v:
Molecular & Cellular Oncology
Molecular & Cellular Oncology, 2016, 3, pp.e1008297. ⟨10.1080/23723556.2015.1008297⟩
Molecular & Cellular Oncology, Taylor et Francis, 2016, 3, pp.e1008297. ⟨10.1080/23723556.2015.1008297⟩
Molecular & Cellular Oncology, 2016, 3, pp.e1008297. ⟨10.1080/23723556.2015.1008297⟩
Molecular & Cellular Oncology, Taylor et Francis, 2016, 3, pp.e1008297. ⟨10.1080/23723556.2015.1008297⟩
International audience; Replication stress has emerged as a key driver of oncogenesis but also represents an Achilles’ heel of cancer cells. Newly reported SUMO binding and SUMO ligase functions of the DNA repair SLX4 protein that impact the outcom
Autor:
Pauline Rimmelé, Jean-Hugues Guervilly, Christel Guillouf, Françoise Moreau-Gachelin, Filippo Rosselli
Publikováno v:
Blood. 124:2193-2193
The multistage process of leukemic formation is driven by the progressive acquisition of somatic mutations. Replication stress creates genomic instability in mammals. Oncogenes and tumor suppressors trigger a replicative stress, that will consequentl
Autor:
Filippo Rosselli, Jean-Hugues Guervilly, Massimo Bogliolo, Jean Antoine Dugas du Villard, Gaëtane Macé
Publikováno v:
Biochimie. 87(7)
Fanconi anemia (FA) is a recessive cancer prone syndrome featuring bone marrow failure and hypersensitivity to DNA crosslinks. Nine FA genes have been isolated so far. The biochemical function(s) of the FA proteins remain(s) poorly determined. Howeve