Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jean-Francois Thibodeau"'
Autor:
Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Current research on hypertension utilizes more than fifty animal models that rely mainly on stable increases in systolic blood pressure. In experimental hypertension, grading or scoring of glomerulopathy in the majority of studies is based on a wide
Externí odkaz:
https://doaj.org/article/40afb53ba6f94bf39247fe6e8cea6b00
Autor:
Jean-Francois Thibodeau, Chet E Holterman, Dylan Burger, Naomi C Read, Timothy L Reudelhuber, Christopher R J Kennedy
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113459 (2014)
Currently available rodent models exhibit characteristics of early diabetic nephropathy (DN) such as hyperfiltration, mesangial expansion, and albuminuria yet features of late DN (hypertension, GFR decline, tubulointerstitial fibrosis) are absent or
Externí odkaz:
https://doaj.org/article/b5c589d397aa4c7184b244dd7073af06
Autor:
Dylan Burger, Christopher R.J. Kennedy, Alex Gutsol, Jean-Francois Thibodeau, Susan J. Robertson, Richard L. Hébert, Jamie Ghossein, Rania Nasrallah, Fengxia Xiao, Kevin D. Burns, Joseph Zimpelmann
Publikováno v:
Laboratory Investigation. 100:414-425
Prostaglandin E2 receptor EP1 (PGE2/EP1) promotes diabetic renal injury, and EP1 receptor deletion improves hyperfiltration, albuminuria, and fibrosis. The role of EP1 receptors in hypertensive kidney disease (HKD) remains controversial. We examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5e0a7d2b16ed13bcb718a835a56f153
https://doi.org/10.1038/s41374-019-0317-7
https://doi.org/10.1038/s41374-019-0317-7
Autor:
Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns
Publikováno v:
PloS one. 17(2)
Current research on hypertension utilizes more than fifty animal models that rely mainly on stable increases in systolic blood pressure. In experimental hypertension, grading or scoring of glomerulopathy in the majority of studies is based on a wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428e6f3623a7975de4e8a4aae041cec8
https://pubmed.ncbi.nlm.nih.gov/35176122
https://pubmed.ncbi.nlm.nih.gov/35176122
Autor:
Eldjonai Kamto, Melica Novakovic, Naomi C. Boisvert, Khaled S. Abd-Elrahman, Jean-Francois Thibodeau, Stephen S. G. Ferguson, Chet E. Holterman, Christopher R.J. Kennedy
Publikováno v:
Antioxidants & Redox Signaling. 30:1817-1830
Oxidative stress associated with a proinflammatory state occurs in endothelial dysfunction, hypertension, chronic kidney disease, and diabetes. The NADPH oxidase (Nox) family of reactive oxygen species (ROS) generating enzymes is implicated in these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7fb55ff004d41b30cb5f5ec2449d47
https://doi.org/10.1089/ars.2017.7402
https://doi.org/10.1089/ars.2017.7402
Autor:
Luciano da Fontoura Costa, Peter Van Dyken, Moises Freitas-Andrade, Christopher J. Bergin, Sylvain Baillet, Yannick D. Benoit, Christopher R.J. Kennedy, Baptiste Lacoste, Youlian Pan, Cesar H. Comin, Julie Ouellette, Ziying Liu, Cameron J Morse, Micaël Carrier, Sonia Leclerc, Marie-Ève Tremblay, Mirabelle Ho, Duncan J. Stewart, Dylan Burger, Melissa Yin, María Lacalle-Aurioles, William L. Stanford, Jean-Francois Thibodeau, Xavier Toussay, Qing Yan Liu
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
While the neuronal underpinnings of autism spectrum disorder (ASD) are being unraveled, vascular contributions to ASD remain elusive. Here, we investigated postnatal cerebrovascular development in the 16p11.2df/+ mouse model of 16p11.2 deletion ASD s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd9e5678d97ad9aa478e986a4be657e
https://doi.org/10.1038/s41593-020-0663-1
https://doi.org/10.1038/s41593-020-0663-1
Autor:
Jugurtha Ouboudinar, Ramon Corpuz, Martin Leduc, Jean-Simon Duceppe, Alexandre Laverdure, Mikaël Tremblay, Kathy Hince, Amélie Blais, Marie-Pier Cloutier, Richard L. Hébert, Christopher R.J. Kennedy, Alexandra Blais, Liette Gervais, Lilianne Geerts, Lyne Gagnon, Pierre Laurin, Jean-Christophe Simard, Steven R. LaPlante, Sylvie Létourneau, Jean-Francois Thibodeau, François A. Leblond, Brigitte Grouix, Shaun D. Abbott, Boulos Zacharie, Alexandra Felton, Vanessa Marques Quintela, William Gagnon, François Sarra-Bournet
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease and is associated with metabolic dysregulation. Although G protein-coupled receptor 84 (GPR84) has been associated with inflammation, its role in metabolic regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7b27b3602799ec5543996bcf182aca
http://europepmc.org/articles/PMC7391726
http://europepmc.org/articles/PMC7391726
Autor:
Chet E. Holterman, Jean-Francois Thibodeau, Amélie Blais, Richard L. Hébert, Véronique Cheff, Chris R. J. Kennedy
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Fatty acid receptors have recently been implicated in the progression of fibrotic disorders. GPR40 deletion predisposes to AKI and CKD-induced fibrosis, while deletion of the pro-inflammatory GPR84 receptor was beneficial in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2442d241dd8f8a75cce684203d9dfd83
https://doi.org/10.1093/ndt/gfaa142.p0710
https://doi.org/10.1093/ndt/gfaa142.p0710
Autor:
Jean-Francois Thibodeau, Alexandre Laverdure, Kathy Hince, Richard L. Hébert, Alex Gutsol, William Gagnon, Martin Leduc, Eldjonai Kamto, Liette Gervais, Shaun D. Abbott, Christopher R.J. Kennedy, Francois A. Leblond, Jonathan Richard, Pierre Laurin, Chet E. Holterman, Alexandra Felton, Ming-Zhi Zhang, François Sarra-Bournet, Mikaël Tremblay, Jugurtha Ouboudinar, Lilianne Geerts, Christopher Penney, Lyne Gagnon, Jocelyn Dupuis, Jean-Christophe Simard, Jean-Simon Duceppe, Quang Trinh Nguyen, Marie-Pier Cloutier, Raymond C. Harris, Angelino Calderone, Brigitte Grouix, Boulos Zacharie, Sylvie Létourneau
Publikováno v:
The American Journal of Pathology. 188:1132-1148
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 and GPR84 are G protein–coupled receptors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7315d43b6a70e40dd65fdef9ae6ea14c
https://doi.org/10.1016/j.ajpath.2018.01.009
https://doi.org/10.1016/j.ajpath.2018.01.009
Autor:
Brigitte Grouix, Jean-Christophe Simard, Jean-Francois Thibodeau, Mikaël Tremblay, Alexandre Laverdure, François Sarra-Bournet, Ramon Corpuz, Lyne Gagnon
Publikováno v:
Journal of Hepatology. 73:S656-S657
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d45f79a53697b31977a8a67667c5558
https://doi.org/10.1016/s0168-8278(20)31775-x
https://doi.org/10.1016/s0168-8278(20)31775-x