Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jean-Francois Mouscadet"'
Autor:
Kevin Carayon, Li Na, Olivier Delelis, Francoise Simon, Jean-Francois Mouscadet, Jean-Claude Brochon, Eric Deprez
Publikováno v:
Biophysical Journal. 96(3)
Compounds targeting HIV-1 integrase multimerization process represent an interesting approach with likely no cross-resistance with other compounds such as strand-transfer inhibitors (INSTI). To get deeper insight into the role of the zinc-binding dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3ff6a2bd446caafd7309fc490b0428
Publikováno v:
Chemicalpharmaceutical bulletin. 50(12)
A systematic series of chemically modified coumarin dimmers has been synthesized and tested for their inhibitory activity against HIV-1 integrase. We observed that modified coumarin dimmers containing hydrophobic moiety on the linker display potent i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12273b8c809068125ac0c22b153cfb94
https://pubmed.ncbi.nlm.nih.gov/12499608
https://pubmed.ncbi.nlm.nih.gov/12499608
Publikováno v:
Molecules, Vol 15, Iss 5, Pp 3048-3078 (2010)
In spite of significant progress in anti-HIV-1 therapy, current antiviral chemo-therapy still suffers from deleterious side effects and emerging drug resistance. Therefore, the development of novel antiviral drugs remains a crucial issue for the figh
Externí odkaz:
https://doaj.org/article/d5f1d2ef090f467b991ff19ad48c6b7d
Autor:
Gwenola Manic, Aurélie Maurin-Marlin, Fanny Laurent, Ilio Vitale, Sylvain Thierry, Olivier Delelis, Philippe Dessen, Michelle Vincendeau, Christine Leib-Mösch, Uriel Hazan, Jean-François Mouscadet, Stéphanie Bury-Moné
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69691 (2013)
Ku, a cellular complex required for human cell survival and involved in double strand break DNA repair and multiple other cellular processes, may modulate retroviral multiplication, although the precise mechanism through which it acts is still contro
Externí odkaz:
https://doaj.org/article/3b232a1968ae45008281de4a164029d6
Autor:
Xiaoju Ni, Safwat Abdel-Azeim, Elodie Laine, Rohit Arora, Osamuede Osemwota, Anne-Geneviève Marcelin, Vincent Calvez, Jean-François Mouscadet, Luba Tchertanov
Publikováno v:
Advances in Virology, Vol 2012 (2012)
Most antiretroviral medical treatments were developed and tested principally on HIV-1 B nonrecombinant strain, which represents less than 10% of the worldwide HIV-1-infected population. HIV-1 circulating recombinant form CRF02_AG is prevalent in West
Externí odkaz:
https://doaj.org/article/d9f9cb628c4a464caf5ee0fa2dc27116
Autor:
Olivier Delelis, Vincent Parissi, Hervé Leh, Gladys Mbemba, Caroline Petit, Pierre Sonigo, Eric Deprez, Jean-François Mouscadet
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e608 (2007)
BACKGROUND: HIV-1 integrase (IN) catalyses the retroviral integration process, removing two nucleotides from each long terminal repeat and inserting the processed viral DNA into the target DNA. It is widely assumed that the strand transfer step has n
Externí odkaz:
https://doaj.org/article/22e2c5e08bc8405293a92f5115fcfafc
Autor:
Ni, Xiaoju
Publikováno v:
Agricultural sciences. École normale supérieure de Cachan-ENS Cachan, 2011. English. ⟨NNT : 2011DENS0037⟩
Biotechnology. École normale supérieure de Cachan-ENS Cachan, 2011. English
Biotechnology. École normale supérieure de Cachan-ENS Cachan, 2011. English
This thesis presents the determination of susceptibility and resistance of HIV integrases (INs) to IN strand transfer inhibitors (INSTIs) and the development of single domain antibody (sdAb) targeting HIV IN. Firstly, the susceptibility of HIV-1 subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f8d57246b1197909ad5ae140eec9ad49
https://tel.archives-ouvertes.fr/tel-00654080/file/Ni2011.pdf
https://tel.archives-ouvertes.fr/tel-00654080/file/Ni2011.pdf
