Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase

Autor: Benoît Pinson, Irène Ceballos-Picot, Renaud Morales, Robert Barouki, Bertrand Daignan-Fornier, G.M. Pinon, Anne Olivier-Bandini, Françoise Chesney, Jessica Huyet, Franck Augé, Christelle Saint-Marc, Roland Lupoli, Abdul Rauf Siddiqi, Pierre Nioche, Mohammad Ozeir, Jean-Marc Remy, Jean-Francois Gibert, Marie-Claude Burgevin

Publikováno v: Cell Chemical Biology
Cell Chemical Biology, Cell Press, 2018, 25 (6), pp.666-676.e4. ⟨10.1016/j.chembiol.2018.02.011⟩

Summary Phosphoribosyltransferases catalyze the displacement of a PRPP α-1′-pyrophosphate to a nitrogen-containing nucleobase. How they control the balance of substrates/products binding and activities is poorly understood. Here, we investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd7c0c1339d7dfe2220644525a69f0c
https://pubmed.ncbi.nlm.nih.gov/29576532