Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jean-François Théberge"'
Autor:
David Y. Thomas, Hannah M. Heath-Engel, Michel L. Tremblay, Jean-François Théberge, Eric Chevet, Kurt Dejgaard
Publikováno v:
Journal of Proteome Research. 9:1763-1771
Cotranslational translocation of polypeptides into the ER is controlled by the dynamic interaction of ribosome and translocon components. Analysis of the steps involved in this process by high resolution techniques such as gel electrophoresis is prec
Autor:
Ying-Chih Liu, Christophe Blanchetot, Jean-François Théberge, Annie Bourdeau, Maxime Hallé, Serge Hardy, Michel L. Tremblay, Tzu-Ching Meng
Publikováno v:
Molecular and Cellular Biology. 27:1172-1190
The protein tyrosine phosphatase PEST (PTP-PEST) is involved in the regulation of the actin cytoskeleton. Despite the emerging functions attributed to both PTPs and the actin cytoskeleton in apoptosis, the involvement of PTP-PEST in apoptotic cell de
Autor:
Annie Bourdeau, Karen M. Doody, Michel L. Tremblay, Nadia Dubé, Jean-François Théberge, Krista M. Heinonen
Publikováno v:
Blood. 109:4220-4228
The T-cell protein tyrosine phosphatase (TC-PTP) is a negative regulator of the Jak/Stat cytokine signaling pathway. Our study shows that the absence of TC-PTP leads to an early bone marrow B-cell deficiency characterized by hindered transition from
Publikováno v:
Archives of Biochemistry and Biophysics. 420:9-17
Vanadium salts such as vanadyl sulfate (VS), potent inhibitors of protein tyrosine phosphatases, have been shown to mimic, augment, and prolong insulin’s action. However, the molecular mechanism of responses to these salts is not clear. In the pres
Autor:
Diego Miranda-Saavedra, Kelly A. Pike, Michel L. Tremblay, Valerie Vinette, Andrew P. Hutchins, Laurent Sabbagh, Jean-François Théberge
Publikováno v:
Science Signaling. 7
Both pro- and anti-inflammatory cytokines activate the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway; however, they elicit distinct transcriptional programs. Posttranslational modifications of STAT proteins, such
Publikováno v:
Cell biochemistry and biophysics. 44(1)
Among several metals, vanadium has emerged as an extremely potent agent with insulin-like properties. These insulin-like properties have been demonstrated in isolated cells, tissues, different animal models of type I and type II diabetes as well as a
Autor:
Jean-François Côté, Laurence A. Lasky, Maxime Hallé, Susan D. Spencer, Ping Lin Chung, Jean-François Théberge, Michel L. Tremblay
Publikováno v:
The Journal of biological chemistry. 277(4)
PSTPIP is a tyrosine-phosphorylated protein involved in the organization of the cytoskeleton. Its ectopic expression induces filipodial-like membrane extensions in NIH 3T3 cells. We previously observed a defect in cytokinesis and an increase in the t