Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Jean-François Peyron"'
Autor:
Anthony Kypraios, Juba Bennour, Véronique Imbert, Léa David, Julien Calvo, Françoise Pflumio, Raphaël Bonnet, Marie Couralet, Virginie Magnone, Kevin Lebrigand, Pascal Barbry, Pierre S. Rohrlich, Jean-François Peyron
Publikováno v:
Cancers, Vol 16, Iss 9, p 1667 (2024)
Pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL) relapses are still associated with a dismal outcome, justifying the search for new therapeutic targets and relapse biomarkers. Using single-cell RNA sequencing (scRNAseq) data from three paired sa
Externí odkaz:
https://doaj.org/article/7e1c0f590f4f49b08a94c5e6f2878595
Autor:
Fabien Muselli, Lucas Mourgues, Nathalie Rochet, Marielle Nebout, Agnès Guerci, Els Verhoeyen, Adrien Krug, Laurence Legros, Jean-François Peyron, Didier Mary
Publikováno v:
Cancers, Vol 15, Iss 3, p 995 (2023)
Background & aims: In CML, Leukemic Stem Cells (LSCs) that are insensitive to Tyrosine Kinase Inhibitors are responsible for leukemia maintenance and relapses upon TKI treatment arrest. We previously showed that downregulation of the BMI1 polycomb pr
Externí odkaz:
https://doaj.org/article/38badc0560ae4fac8c792b0127343ea7
Autor:
Flaviano S Martins, Guillaume Dalmasso, Rosa M E Arantes, Anne Doye, Emmanuel Lemichez, Patricia Lagadec, Veronique Imbert, Jean-François Peyron, Patrick Rampal, Jacques R Nicoli, Dorota Czerucka
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0267067 (2022)
[This corrects the article DOI: 10.1371/journal.pone.0008925.].
Externí odkaz:
https://doaj.org/article/fa5dee75939043bd8e6e13c18017023c
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262751 (2022)
Drug repurposing can be an interesting strategy for an emergency response to the severe acute respiratory syndrome-coronavirus-2, (SARS-COV-2), the causing agent of the coronavirus disease-19 (COVID-19) pandemic. For this, we applied the Connectivity
Externí odkaz:
https://doaj.org/article/fd05d783a5724a26aadf70a2bed6469e
Autor:
Stéphane J.C. Mancini, Karl Balabanian, Isabelle Corre, Julie Gavard, Gwendal Lazennec, Marie-Caroline Le Bousse-Kerdilès, Fawzia Louache, Véronique Maguer-Satta, Nathalie M. Mazure, Fatima Mechta-Grigoriou, Jean-François Peyron, Valérie Trichet, Olivier Herault
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Knowledge about the hematopoietic niche has evolved considerably in recent years, in particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity in the human bone marrow, in particular in a context of hematological ma
Externí odkaz:
https://doaj.org/article/cb6393dbb52c4389b81b57399a686a9c
Autor:
Raphaël Bonnet, Marielle Nebout, Carine Brousse, Frédéric Reinier, Véronique Imbert, Pierre Simon Rohrlich, Jean-François Peyron
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive subtype of leukemia for which important progress in treatment efficiency have been made in the past decades to reach a cure rate of 75%–80% nowadays. It is nevertheless mandatory to find
Externí odkaz:
https://doaj.org/article/b35b23e9be6e451d8965d17516c4ebe6
Autor:
Abderrahman Chargui, Amine Belaid, Papa Diogop Ndiaye, Véronique Imbert, Michel Samson, Jean-Marie Guigonis, Michel Tauc, Jean-François Peyron, Philippe Poujeol, Patrick Brest, Paul Hofman, Baharia Mograbi
Publikováno v:
Cancers, Vol 13, Iss 10, p 2490 (2021)
Signaling, proliferation, and inflammation are dependent on K63-linked ubiquitination—conjugation of a chain of ubiquitin molecules linked via lysine 63. However, very little information is currently available about how K63-linked ubiquitination is
Externí odkaz:
https://doaj.org/article/41013859a18e4463b3d04b0b658ab504
Autor:
Fabien Muselli, Lucas Mourgues, Rita Morcos, Nathalie Rochet, Marielle Nebout, Agnès Guerci-Bresler, Douglas V Faller, Robert M William, Rana Mhaidly, Els Verhoeyen, Laurence Legros, Jean-François Peyron, Didier Mary
Publikováno v:
Cancers, Vol 13, Iss 7, p 1693 (2021)
Numerous combinations of signaling pathway blockades in association with tyrosine kinase inhibitor (TKI) treatment have been proposed for eradicating leukemic stem cells (LSCs) in chronic myeloid leukemia (CML), but none are currently clinically avai
Externí odkaz:
https://doaj.org/article/330504ff765f45c2a1ced7f16d954d2e
Autor:
Alexander G. Myasnikov, S. Kundhavai Natchiar, Marielle Nebout, Isabelle Hazemann, Véronique Imbert, Heena Khatter, Jean-François Peyron, Bruno P. Klaholz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the r
Externí odkaz:
https://doaj.org/article/5c015c0b3ce04e609d082a4c3d51b4f2
Autor:
Arnaud Gilles, Léo Frechin, Kundhavai Natchiar, Giulia Biondani, Ottilie von Loeffelholz, Samuel Holvec, Julie-Lisa Malaval, Jean-Yves Winum, Bruno P. Klaholz, Jean-François Peyron
Publikováno v:
Cells, Vol 9, Iss 3, p 629 (2020)
The human 80S ribosome is the cellular nucleoprotein nanomachine in charge of protein synthesis that is profoundly affected during cancer transformation by oncogenic proteins and provides cancerous proliferating cells with proteins and therefore biom
Externí odkaz:
https://doaj.org/article/51a51ba49fdd41e1becad79ba38ba959