Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Jean-François Michiels"'
Autor:
Ilaria Di Mauro, Lénaïg Mescam-Mancini, Bruno Chetaille, Marick Lae, Gaelle Pierron, Bérengère Dadone-Montaudie, Audrey Bazin, Corinne Bouvier, Jean-François Michiels, Florence Pedeutour
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 8, Pp 311-321 (2020)
The detection of specific alterations by genetic analyses has been included in the diagnostic criterions of the World Health Organization’s classification of soft tissues tumors since 2013. The presence of a SS18 rearrangement is pathognomonic of s
Externí odkaz:
https://doaj.org/article/d784f03a5daf43d586229fb85a5f7007
Publikováno v:
Cells, Vol 11, Iss 3, p 541 (2022)
A plethora of factors have been attributed to underly aging, including oxidative stress, telomere shortening and cellular senescence. Several studies have shown a significant role of the cyclin-dependent kinase inhibitor p16ink4a in senescence and ag
Externí odkaz:
https://doaj.org/article/8ef5c587293e45a0aea4caa406f2ce64
Autor:
Nicole Wagner, Marina Ninkov, Ana Vukolic, Günseli Cubukcuoglu Deniz, Minoo Rassoulzadegan, Jean-François Michiels, Kay-Dietrich Wagner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4346 (2021)
The Wilms’ tumor suppressor Wt1 is involved in multiple developmental processes and adult tissue homeostasis. The first phenotypes recognized in Wt1 knockout mice were developmental cardiac and kidney defects. Wt1 expression in the heart has been d
Externí odkaz:
https://doaj.org/article/61f7616acb55428e92456e4cdb8c7e44
Autor:
Camille Loubiere, Stephan Clavel, Jerome Gilleron, Rania Harisseh, Jeremy Fauconnier, Issam Ben-Sahra, Lisa Kaminski, Kathiane Laurent, Stephanie Herkenne, Sandra Lacas-Gervais, Damien Ambrosetti, Damien Alcor, Stephane Rocchi, Mireille Cormont, Jean-François Michiels, Bernard Mari, Nathalie M. Mazure, Luca Scorrano, Alain Lacampagne, Abdallah Gharib, Jean-François Tanti, Frederic Bost
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress,
Externí odkaz:
https://doaj.org/article/3c81dba573894f44b340dafd88a5e78b
Autor:
Bérengère Dadone-Montaudié, Audrey Laroche-Clary, Aline Mongis, Emmanuel Chamorey, Ilaria Di Mauro, Vanessa Chaire, Pascal Finetti, Renaud Schiappa, François Le Loarer, Isabelle Birtwisle-Peyrottes, Jean-François Michiels, François Bertucci, Florence Pedeutour, Antoine Italiano, Laurence Bianchini
Publikováno v:
Cancers, Vol 12, Iss 10, p 3058 (2020)
We aimed to evaluate the therapeutic potential of the pan-FGFR inhibitor erdafitinib to treat dedifferentiated liposarcoma (DDLPS). FGFR expression and their prognostic value were assessed in a series of 694 samples of well-differentiated/dedifferent
Externí odkaz:
https://doaj.org/article/53fe1b0b90f147f3acb8fe089dbd8af5
Autor:
Christian H. Roux, Didier F. Pisani, Pierre Gillet, Eric Fontas, Hédi Ben Yahia, Mansour Djedaini, Damien Ambrosetti, Jean-François Michiels, Patricia Panaia-Ferrari, Véronique Breuil, Astrid Pinzano, Ez-Zoubir Amri
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3966 (2020)
This study investigated the relationship of oxytocin (OT) to chondrogenesis and osteoarthritis (OA). Human bone marrow and multipotent adipose-derived stem cells were cultured in vitro in the absence or presence of OT and assayed for mRNA transcript
Externí odkaz:
https://doaj.org/article/cc0c9e1538c8400db456372b6953074f
Publikováno v:
PPAR Research, Vol 2018 (2018)
Externí odkaz:
https://doaj.org/article/2d23c8a024614296a41387e11c7696cf
Autor:
Mounir El Maï, Kay-Dietrich Wagner, Jean-François Michiels, Damien Ambrosetti, Arnaud Borderie, Sandrine Destree, Valerie Renault, Nadir Djerbi, Marie-Josèphe Giraud-Panis, Eric Gilson, Nicole Wagner
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 1047-1060 (2014)
Telomeric repeat binding factor 2 (TRF2), which plays a central role in telomere capping, is frequently increased in human tumors. We reveal here that TRF2 is expressed in the vasculature of most human cancer types, where it colocalizes with the Wilm
Externí odkaz:
https://doaj.org/article/84e128f508cb4b6d8d4a403357905453
Autor:
Nicolas Chevalier, Rachel Paul-Bellon, Philippe Camparo, Jean-François Michiels, Daniel Chevallier, Patrick Fénichel
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 1574-1589 (2014)
Testicular germ cell tumors (TGCTs) are the most common solid cancers in young men, with an increasing incidence over several years. However, their pathogenesis remains a matter of debate. Some epidemiological data suggest the involvement of both env
Externí odkaz:
https://doaj.org/article/44fc33e8b83a4071a1e63078b52e225f
Autor:
Kay-Dietrich Wagner, Mounir El Maï, Michael Ladomery, Tareg Belali, Nathalie Leccia, Jean-François Michiels, Nicole Wagner
Publikováno v:
Cells, Vol 8, Iss 1, p 41 (2019)
Angiogenesis is one hallmark of cancer. Vascular endothelial growth factor (VEGF) is a known inducer of angiogenesis. Many patients benefit from antiangiogenic therapies, which however have limitations. Although VEGF is overexpressed in most tumors,
Externí odkaz:
https://doaj.org/article/155502f1fcf7492bb9184896f92bb159