Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jean-François Liégeois"'
Autor:
Stephan A. Pless, Marie Vitello, Dominique Engel, Vincent Seutin, Sofian Ringlet, Laurent Massotte, Jean-François Liégeois, Jochen Roeper, Kevin Jehasse, Bernard Lakaye, Sebastian Hartmann, Han Chow Chua, Romain Vitello
Publikováno v:
Neuropharmacology. 197
Although several ionic mechanisms are known to control rate and regularity of the slow pacemaker in dopamine (DA) neurons, the core mechanism of pacing is controversial. Here we tested the hypothesis that pacemaking of SNc DA neurons is enabled by an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7732693ef5efa8abf3b555d0004e1882
https://pubmed.ncbi.nlm.nih.gov/34273387
https://pubmed.ncbi.nlm.nih.gov/34273387
Autor:
Jivago Ropke, Fabrício A. Moreira, Lívia Carla de Melo Rodrigues, Yane C P Andrade, Elaine Aparecida Del Bel, A.C. Issy, Chiara Fanelli, Thércia G. Viana, Jean-François Liégeois, Luara A. Batista, Elisa Minaldi
Publikováno v:
Behavioural pharmacology. 32(1)
The pyridobenzoxazepine compound, 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13), has been developed as a potential antipsychotic drug. We tested the hypothesis that JL13 is efficacious in both dopaminergic and glutamaterg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fdb7b30242ba0de6657f846c66ff92
https://pubmed.ncbi.nlm.nih.gov/33399294
https://pubmed.ncbi.nlm.nih.gov/33399294
Autor:
Jean-François Liégeois, Sylvia Hartmann, Dominique Engel, Sofian Ringlet, Laurent Massotte, Jochen Roeper, Kevin Jehasse, Seutin, Romain Vitello, Stephan A. Pless, Bernard Lakaye, Vitello M, Han Chow Chua
Although several ionic mechanisms are known to control rate and regularity of the pacemaker in dopamine (DA) neurons from the substantia nigra pars compacta (SNc), a conductance essential for pacing has yet to be defined. Here we provide pharmacologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d78b10051e6961e16bb31d08c1d6e1
https://doi.org/10.1101/2020.12.16.423073
https://doi.org/10.1101/2020.12.16.423073
Publikováno v:
Acta Physiol (Oxf)
AIM: Small-conductance Ca(2+)-activated potassium (SK) channels are activated exclusively by increases in intracellular Ca(2+), that binds to calmodulin constitutively associated with the channel. Wild-type SK2 channels are activated by Ca(2+) with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3875f8c5a2718717a9ab782d19dcac24
https://doi.org/10.1111/apha.13574
https://doi.org/10.1111/apha.13574
Publikováno v:
Journal of Chemical Information and Modeling. 56:1324-1331
The resurgence of interest in 5-HT1A receptors as a therapeutic target requires the existence of highly selective 5-HT1A ligands. To date, WAY-100635 has been the prototypical antagonist of these receptors. However, this compound also has significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3d728f63fdddddac6e1aacba79bfdf
https://doi.org/10.1021/acs.jcim.5b00753
https://doi.org/10.1021/acs.jcim.5b00753
Autor:
Jean-François Liégeois, Fabien Dufour, Vincent Seutin, Sébastien Dilly, Johan Wouters, Iolanda Nistor, Philippe Hubert, Eduard Badarau
Publikováno v:
Journal of Molecular Structure. 1074:435-440
Reduction of symmetrical bis-isoquinolinium derivatives with sodium borohydride generates normally a mixture of three 1,2,3,4-tetrahydroisoquinoline stereoisomers. In a series of 8-isopropyl analogues, chiral resolution failed for the analogues with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59664d2200aa8ce665e11168397851a
https://doi.org/10.1016/j.molstruc.2014.06.042
https://doi.org/10.1016/j.molstruc.2014.06.042
Autor:
Eduard Badarau, Attilio Ceccato, Pierre Lebrun, Radu Oprean, Fabien Dufour, Frédéric Lecomte, Ines Slama, Iolanda Nistor, Philippe Hubert, Eric Rozet, Katina Sourou Sylvestre Dossou, Jean-François Liégeois, Marianne Fillet
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 74:273-283
This paper focuses on implementing a design space approach and on the critical process parameters (CPPs) to consider when applying the Quality by Design (QbD) concepts outlined in ICH Q8(R2), Q9 and Q10 to analytical method development and optimizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd5f1202ebfa452691e586bc7f24586
https://doi.org/10.1016/j.jpba.2012.10.015
https://doi.org/10.1016/j.jpba.2012.10.015
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors
Autor:
Jon Evans, Sébastien Dilly, Floriane Mangin, Benoît Joly, Vincent Setola, Bryan L. Roth, Jacqueline Scuvée-Moreau, Jean-François Liégeois
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4550-4554
The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety (3i). The 4-phenyl-1,2,3,6-tetrahydropyridine c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10c3f40243183756369a2658201beff
https://doi.org/10.1016/j.bmcl.2012.05.119
https://doi.org/10.1016/j.bmcl.2012.05.119
Autor:
Frank I. Tarazi, Mélissa Résimont, Cédric Lamy, Floriane Mangin, Sébastien Dilly, Marine Deville, Jean-François Liégeois
Publikováno v:
Journal of Medicinal Chemistry. 55:1572-1582
A series of new pyridobenzoxazepine derivatives with various heterocyclic amine side chains were synthesized to explore two main parameters related to the distal basic nitrogen. These compounds were tested for their affinity for dopamine D(2L) and D(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853a9ead463a96a7062bf871837a1736
https://doi.org/10.1021/jm2013419
https://doi.org/10.1021/jm2013419
Autor:
Sylvie Poncin, Fabien Dufour, Jean-François Liégeois, Sébastien Dilly, Eduard Badarau, Vincent Seutin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6756-6759
A structure–activity relationship study of N-methyl-laudanosine, a SK channel blocker, has indicated that the 6,7-dimethoxy group could be successfully replaced by a hydrophobic moiety such as an isopropyl substituent in position 8 of the isoquinol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64df6c9d13dcc14bcf77cb42a86f44e9
https://doi.org/10.1016/j.bmcl.2011.09.043
https://doi.org/10.1016/j.bmcl.2011.09.043