Evaluation of a Model of Long-Term Middle Ear Catheterization for Repeat Infusion Administration and Cochlear Hair Cell Injury in Guinea Pigs

Autor: Frederick Emond, Jean-François Lafond, Kelly Tenneson, Claudia Foucault, Susan Vogel, Hamid Boubekeur

Publikováno v: Toxicologic Pathology. 48:586-592

Middle ear administration has numerous applications, including antibiotherapy and gene therapy, and is increasingly used to target the auditory and vestibular systems. In animal studies, investigating repeated exposure that mimics clinical dosing reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d076576fc1da89c446f50c273a1a70f9
https://doi.org/10.1177/0192623320916635

Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate

Autor: Frederick Emond, David P. Corey, Bence György, Jean-François Lafond, Kelly Tenneson, Elise J. Meijer, Vladimir K. Berezovskii, Casey A. Maguire, Richard T. Born, Mark Vezina, Panos I. Tamvakologos, Maureen O’Brien, Maryna V. Ivanchenko, Adrienn Volak, Yvan Arsenijevic, K. Domenica Karavitaki, Margaret A. Kenna, Artur A. Indzhykulian, Killian S. Hanlon

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular therapy. Methods & clinical development, vol. 13, pp. 1-13
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 1-13 (2019)

Hereditary hearing loss often results from mutation of genes expressed by cochlear hair cells. Gene addition using AAV vectors has shown some efficacy in mouse models, but clinical application requires two additional advances. First, new AAV capsids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243036e32a7b7508f18a2d8c25150f00
http://europepmc.org/articles/PMC6297893

Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea

Autor: Frederick Emond, Maya K. Devine, Maryna V. Ivanchenko, David P. Corey, Margaret A. Kenna, Kelly Tenneson, Casey A. Maguire, Jean-François Lafond, Killian S. Hanlon

Publikováno v: Hear Res

In a number of mouse models of hereditary deafness, therapeutic transgene delivery to the cochlea and vestibular organs using adeno-associated viral vectors (AAVs) has shown striking rescue of hearing and balance. However, only a subset of AAV capsid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5309b8a015915f7e30a89374b2d8e3
https://doi.org/10.1016/j.heares.2020.107930

ORIGINAL ARTICLE: Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta)

Autor: E.D. Lombardini, Terrell W. Blanchard, R. Virmani, Jean-François Lafond, M. Doré, S. Ménard

Publikováno v: Journal of Medical Primatology. 39:315-317

Background A 9-year-old, male castrate, Rhesus macaque was euthanized following a prolonged history of chronic renal failure. Results Necropsy revealed a proliferative lesion within the right cardiac auricle composed of neoplastic epithelioid cells w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4432c573c280f744071f472fa808d755
https://doi.org/10.1111/j.1600-0684.2010.00411.x

Fibrous vaginal hamartoma in a newborn calf

Autor: Jean-François, Lafond, Pierre-Yves, Mulon, Richard, Drolet

Publikováno v: The Canadian veterinary journal = La revue veterinaire canadienne. 49(1)

A 2-day-old female Holstein calf was presented for abnormal structures protruding from the vulva at birth. A diagnosis of fibrous vaginal hamartoma was made, based on macroscopic and histologic examinations of the abnormal tissue. Management of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a101761c00fed253704107067991a27c
https://pubmed.ncbi.nlm.nih.gov/18320980