Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jean-François Lévesque"'
Autor:
Sébastien Gagné, Sheldon Crane, Zheng Huang, Chun Sing Li, Kevin P. Bateman, Jean-François Lévesque
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 1, Pp 252-259 (2007)
Imbalanced fatty acid metabolism contributes significantly to the increased incidence of metabolic disorders. Isotope-labeled fatty acids (2H, 13C) provide efficient means to trace fatty acid metabolism in vivo. This study reports a new and rapid met
Externí odkaz:
https://doaj.org/article/e82e6e471ebd4ca2a1a328ba3773d65d
Publikováno v:
Revue internationale des technologies en pédagogie universitaire, Vol 7, Iss 3, p 19 (2010)
Il est désormais devenu indispensable de maîtriser les technologies de l’information et de la communication (TIC) pour entreprendre avec succès des études universitaires. Sur ce point, la prise de conscience est de plus en plus forte et la ques
Externí odkaz:
https://doaj.org/article/4ae1ab587d7b45b8aa9d2d4f58c759f8
Publikováno v:
Revue Interventions Économiques, Vol 68
Territorial social innovation (IST) aims to provide innovative systemic and transformative solutions to existing and emerging complex social issues in a given territory. One of the strategies increasingly implemented by public authorities and social
Externí odkaz:
https://doaj.org/article/1d5adbecd93a4a7eb895a5fbce02d5f0
Autor:
Jean-François Lévesque
Publikováno v:
Revue québécoise de droit international. 19:53-78
The interpretation of international treaties represents the first true stage of their implementation, necessary to their respect as a code of conduct and their application as a norm in a case of litigation. Even if the articles 31 to 33 of the Vienna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb6753c757102652f3882799432109c
https://doi.org/10.7202/1069150ar
https://doi.org/10.7202/1069150ar
Autor:
Jean-François Lévesque, Marc Boutin
Publikováno v:
international journal of stomatology & occlusion medicine. 5:88-93
Background The curves of Spee is an essential component of the sphericity of occlusion and is too often neglected in orthodontic and prostodontic reconstructions. This being said, the different descriptions of the curves of Spee presently available h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72420fb8207549d18e6956f39eaa64b6
https://doi.org/10.1007/s12548-012-0045-8
https://doi.org/10.1007/s12548-012-0045-8
Autor:
Sébastien Gagné, Amandine Chefson, Sylvie Toulmond, Patrick Lacombe, Mélissa Arbour, Austin Chen, Dan McKay, Elizabeth Cauchon, Erich L. Grimm, Yeeman K. Ramtohul, M. David Percival, Jean-François Lévesque, Yves Ducharme, Dwight Macdonald, Yongxin Han, René St-Jacques, Robert Houle, Bruce Mackay, Jean-Pierre Falgueyret, Pierre-André Fournier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2670-2674
The design and optimization of a novel isoxazole S(1) linker for renin inhibitor is described herein. This effort culminated in the identification of compound 18, an orally bioavailable, sub-nanomolar renin inhibitor even in the presence of human pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb21bf0f8aa1b021cd6fbd529e12bdc
https://doi.org/10.1016/j.bmcl.2012.03.014
https://doi.org/10.1016/j.bmcl.2012.03.014
Autor:
Kelly Bleasby, Dwight Macdonald, Bruce Mackay, Richard Tschirret-Guth, Robert Houle, Sebastien Laliberte, Patrick Lacombe, Robert Papp, Erich L. Grimm, Amandine Chefson, Jean-François Lévesque, Michael J. Hafey, Pierre-André Fournier, Sébastien Gagné, Yongxin Han, Yves Ducharme, Michel Gallant, Austin Chen, Daniel Dube
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5547-5551
An oral bioavailability issue encountered during the course of lead optimization in the renin program is described herein. The low F(po) of pyridone analogs was shown to be caused by a combination of poor passive permeability and gut efflux transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b390428a9f09b127996a8190fb39ae
https://doi.org/10.1016/j.bmcl.2011.06.095
https://doi.org/10.1016/j.bmcl.2011.06.095
Autor:
Robert Houle, Jean François Lévesque, Daniel Simard, François G. Gervais, Carl Berthelette, Carmela Molinaro, Yves Leblanc, Martine Hamel, Michel Gallant, Helmi Zaghdane, Nicole Sawyer, Susan Sillaots, Zhaoyin Wang, Michael J. Boyd, John Colucci, Rino Stocco
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3471-3474
A new series of indole amide acting as hCRTH2 receptor ligands had been explored and are described herein. Several amide derivatives displaying low nanomolar activity in hCRTH2 binding and whole blood assays were identified. They were found to behave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09028c83914f05337f367fe720b7f52
https://doi.org/10.1016/j.bmcl.2011.03.085
https://doi.org/10.1016/j.bmcl.2011.03.085
Autor:
Joel Robichaud, Nicolas Morin, Sébastien Gagné, Michel Belley, Lianhai Li, Genevieve Lavallee, Geoffrey K. Tranmer, Yves Gareau, Erin F. Mulrooney, W. Cameron Black, Stacia Kargman, Jean-François Lévesque, Joseph A. Mancini, Jacques Yves Gauthier, Jean-François Fournier, Denis Deschenes, Jin Wu, Martine Hamel, Zhaoyin Wang, Michel Therien, Martin Henault, Yaël Mamane, Huda Hyjazie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2836-2839
A weak, UDP-competitive antagonist of the pyrimidinergic receptor P2RY(14) with a naphthoic acid core was identified through high-throughput screening. Optimization provided compounds with improved potency but poor pharmacokinetics. Acylglucuronidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e882d0ef4cdd630e17158a34b627a7e
https://doi.org/10.1016/j.bmcl.2011.03.081
https://doi.org/10.1016/j.bmcl.2011.03.081
Autor:
Stephen M. Soisson, Tom Y.-H. Wu, Michel Gallant, Austin Chen, Dwight Macdonald, Daniel Dube, Robert Houle, Jean-Pierre Falgueyret, Renee Aspiotis, Dan McKay, Jean-François Lévesque, Patrick Roy, Helene Juteau, Sébastien Gagné, M. David Percival, Erich L. Grimm, Sebastien Laliberte, Patrick Lacombe, Elizabeth Cauchon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2430-2436
The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5869451b5d4a9f35f5a8af8a027ba80
https://doi.org/10.1016/j.bmcl.2011.02.067
https://doi.org/10.1016/j.bmcl.2011.02.067