Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jean-François Légaré"'
Autor:
Shreya Sarkar, Jeffrey MacLeod, Ansar Hassan, Keith R. Brunt, Krisan Palmer, Jean-François Légaré
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Frail cardiac surgery patients have an increased risk of worse postoperative outcomes. The purpose of this study was to evaluate the implementation of a novel Telehealth Home monitoring Enhanced-Frailty And Cardiac Surgery (THE-FA
Externí odkaz:
https://doaj.org/article/1640d6d949354a729bca22d88dd19bdf
Autor:
Jeffrey B. MacLeod, Kenneth D’Souza, Christie Aguiar, Craig D. Brown, Zlatko Pozeg, Christopher White, Rakesh C. Arora, Jean-François Légaré, Ansar Hassan
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 17, Iss 1, Pp 1-8 (2022)
Abstract Background While fast track clinical pathways have been demonstrated to reduce resource utilization in patients undergoing cardiac surgery, it remains unclear as to whether they adversely affect post-operative outcomes. The purpose of this s
Externí odkaz:
https://doaj.org/article/854540f570964cf6995e57ee50ebea87
Autor:
Ryan Buyting, MSc, Sarah Melville, BSc (Hons), CRA, Hanif Chatur, MD, CCFP(EM), Christopher W. White, MD, PhD, FRCSC, Jean-François Légaré, MD, FRCSC, Sohrab Lutchmedial, MD, FRCPC, Keith R. Brunt, PhD
Publikováno v:
CJC Open, Vol 4, Iss 2, Pp 133-147 (2022)
Canada is a wealthy nation with a geographically diverse population, seeking health innovations to better serve patients in accordance with the Canada Health Act. In this country, population and geography converge with social determinants, policy, pr
Externí odkaz:
https://doaj.org/article/414d8d30500f4c38af05055eafb9714b
Autor:
Shreya Sarkar, PhD, Jeffrey B. MacLeod, BSc, Ansar Hassan, MD, PhD, Daniel J. Dutton, PhD, Keith R. Brunt, PhD, Jean-François Légaré, MD, PhD
Publikováno v:
JTCVS Open, Vol 8, Iss , Pp 491-502 (2021)
Background: Globally, an increasing number of vulnerable or frail patients are undergoing cardiac surgery. However, large-scale frailty data are often limited by the need for time-consuming frailty assessments. This study aimed to (1) create a retros
Externí odkaz:
https://doaj.org/article/9d5160a61adf40d984a357b7818c7ac8
Autor:
Shreya Sarkar, Stephanie Legere, Ian Haidl, Jean Marshall, Jeffrey B. MacLeod, Christie Aguiar, Sohrab Lutchmedial, Ansar Hassan, Keith R. Brunt, Petra Kienesberger, Thomas Pulinilkunnil, Jean-François Légaré
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Background: Obesity is a risk factor that negatively impacts outcomes in patients undergoing heart surgery by mechanisms that are not well-defined nor predicated on BMI alone. This knowledge gap has fuelled a search for biomarkers associated with car
Externí odkaz:
https://doaj.org/article/69c36a8fbbfb40349e326c5ca49a856c
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Mast cells (MC) are innate immune cells present in virtually all body tissues with key roles in allergic disease and host defense. MCs recognize damage-associated molecular patterns (DAMPs) through expression of multiple receptors including Toll-like
Externí odkaz:
https://doaj.org/article/726f9f85211a4bd8b0d4ae5a7ff18f74
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Mast cells (MC) are innate immune cells present in virtually all body tissues with key roles in allergic disease and host defense. MCs recognize damage-associated molecular patterns (DAMPs) through expression of multiple receptors including Toll-like
Autor:
Dennis T. Ko, MD, MSc, Tareq Ahmed, MPH, Peter C. Austin, PhD, Warren J. Cantor, MD, Paul Dorian, MD, Michael Goldfarb, MD, MSc, Yanyan Gong, MSc, Michelle M. Graham, MD, Jing Gu, MD, PhD, Nathaniel M. Hawkins, MD, MPH, MBChB, Thao Huynh, MD, PhD, Karin H. Humphries, MBA, DSc, Maria Koh, MSc, Yoan Lamarche, MD, MSc, Laurie J. Lambert, PhD, Patrick R. Lawler, MD, MPH, Jean-Francois Légaré, MD, Hung Q. Ly, MD, Feng Qiu, MSc, Ata ur Rehman Quraishi, MBBS, Derek Y. So, MD, MSc, Robert C. Welsh, MD, Harindra C. Wijeysundera, MD, PhD, Graham Wong, MD, MPH, Andrew T. Yan, MD, FRCPC, Yana Gurevich, MD, MPH
Publikováno v:
CJC Open, Vol 3, Iss 8, Pp 1051-1059 (2021)
ABSTRACT: Background: Given changes in the care and outcomes of acute myocardial infarction (AMI) patients over the past several decades, we sought to develop prediction models that could be used to generate accurate risk-adjusted mortality and readm
Externí odkaz:
https://doaj.org/article/e1f4d1cbaf33463d98fa3d331f7b003f
Publikováno v:
Circulation Research. 109
Background: AngiotensinII (AngII) exposure to rodents is a common model of fibrosis, characterized by hypertension, hypertrophy and eventual deposition of excess extracellular matrix (ECM) proteins resulting in organ dysfunction. We have previously s
Autor:
Christie M. Aguiar, Kareem Gawdat, Stephanie Legere, Jean Marshall, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil, Mathieu Castonguay, Keith R. Brunt, Jean-Francois Legare
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background The objectives of the study were to characterize and quantify cellular inflammation and structural remodeling of human atria and correlate findings with molecular markers of inflammation and patient surrogate outcome. Methods Volu
Externí odkaz:
https://doaj.org/article/9c829a9be3d04259b8e79b3e14aaf0df