SP3 Represses the SP1-mediated Transactivation of the HumanCOL2A1 Gene in Primary and De-differentiated Chondrocytes

Autor: Christos Chadjichristos, Philippe Galéra, Jean-François Herrouin, Guntram Suske, Leena Ala-Kokko, Jean-Pierre Pujol, Chafik Ghayor

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2001, 276 (40), pp.36881-36895. ⟨10.1074/jbc.M105083200⟩

International audience; Sp1 and Sp3 effects on the transcription of the human alpha1(II) procollagen gene (COL2A1) were investigated in both differentiated and de-differentiated rabbit articular chondrocytes. Transient transfection with constructs of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc495e81f578af3c8742a330fc1bb3f8
https://doi.org/10.1074/jbc.m105083200

Stimulating effect of diacerein on TGF-β1 and β2 expression in articular chondrocytes cultured with and without interleukin-1

Autor: Jean-François Herrouin, Karim Boumediene, Jean-Pierre Pujol, Philippe Galerra, Nathalie Felisaz, Chafik Ghayor, P Bogdanowicz

Publikováno v: Osteoarthritis and Cartilage. 7:255-264

Objective: Diacetylrhein or diacerein has shown efficacy in the treatment of both major forms of osteoarthritis (OA), coxarthrosis as well as gonarthrosis, improving clinical symptoms of the disease (pain reduction and algo-functional index). Both in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bd1d7cb12298d3c461f916fe83eab6
https://doi.org/10.1053/joca.1998.0199