Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jean-François Haince"'
Autor:
Jean-François Haince, Philippe Joubert, Horacio Bach, Rashid Ahmed Bux, Paramjit S. Tappia, Bram Ramjiawan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1215 (2022)
The five-year survival rate of lung cancer patients is very low, mainly because most newly diagnosed patients present with locally advanced or metastatic disease. Therefore, early diagnosis is key to the successful treatment and management of lung ca
Externí odkaz:
https://doaj.org/article/3fe32fb700134b7fa40fdd46628f54ff
Autor:
Gareth N. Corry, Juan Ausió, Darin McDonald, Hilmar Strickfaden, John Th'ng, Michèle Rouleau, Guy G. Poirier, Toyotaka Ishibashi, Jean-François Haince, Michael J. Kruhlak, D. Alan Underhill, Michael J. Hendzel
Publikováno v:
Journal of Biological Chemistry. 291:1789-1802
Chromatin undergoes a rapid ATP-dependent, ATM and H2AX-independent decondensation when DNA damage is introduced by laser microirradiation. Although the detailed mechanism of this decondensation remains to be determined, the kinetics of decondensatio
Autor:
Nicolas Bertrand, Geneviève Garon, Michel Houde, Timothy J. Holzer, Guillaume Beaudry, Jean-François Haince, Réna G. Deschesnes, Martin Beaulieu, Marie Desaulniers
Publikováno v:
Diagnostic Molecular Pathology. 19:20-27
Up to 30% of patients with stage II (pN0) colon cancer develop recurrences, suggesting that the presence of lymph node (LN) metastases escaped detection at histopathologic staging. A simple way to overcome this limitation and to improve staging accur
A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance
Autor:
Jean-François Haince, G. De Murcia, Olivier J. Becherel, Guy G. Poirier, Padraic Grattan-Smith, Nuri Gueven, Bernd Epe, Marie-Eve Ouellet, Nigel J. Waterhouse, Carmel Mothersill, P. Chen, Robert G. Parton, CH McGowan, Markus Fusser, Orla Howe, Martin F. Lavin, J M De Murcia
Publikováno v:
Cell Death & Differentiation. 14:1149-1161
Several different autosomal recessive genetic disorders characterized by ataxia with oculomotor apraxia (AOA) have been identified with the unifying feature of defective DNA damage recognition and/or repair. We describe here the characterization of a
Autor:
Vincent Fradet, Robert Sabbagh, Neil Fleshner, Yves Fradet, Jean-François Haince, Guillaume Beaudry, Eric Paquet, Lorne Aaron
Publikováno v:
Journal of Urology. 193
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1763:226-237
Poly(ADP-ribosyl)ation is a very early cellular response to DNA damage. Poly(ADP-ribose) (PAR) accumulation is transient since PAR is rapidly hydrolyzed by poly(ADP-ribose) glycohydrolase (PARG). PARG may play a prominent role in DNA damage response
Publikováno v:
Trends in Molecular Medicine. 11:456-463
Recent progress in the field of DNA repair has demonstrated that transient inhibition of DNA damage detection or repair using potent poly(ADP-ribose) polymerase (PARP) inhibitors could improve the efficacy of cancer treatments. Although more study is
Autor:
Shaida A. Andrabi, Jean François Haince, Valina L. Dawson, Karen K. David, Ho Chul Kang, Yingfei Wang, Ted M. Dawson, Guy G. Poirier, No Soo Kim
Publikováno v:
Science Signaling. 4
The mitochondrial protein apoptosis-inducing factor (AIF) plays a pivotal role in poly(ADP-ribose) polymerase-1 (PARP-1)-mediated cell death (parthanatos), during which it is released from the mitochondria and translocates to the nucleus. We show tha
Autor:
Jean-François Haince, Ho Chul Kang, Shaida A. Andrabi, Guy G. Poirier, Yun-Il Lee, Valina L. Dawson, Zhikai Chi, Raymond C. Koehler, Jian Zhang, Andrew B. West, Ted M. Dawson
Publikováno v:
Nature medicine. 17(6)
Glutamate acting on N-methyl-D-aspartate (NMDA) receptors plays an important role in neurodegenerative diseases and neuronal injury following stroke, through activation of poly(ADP-ribose) polymerase-1 and generation of the death molecule poly(ADP-ri
Publikováno v:
Methods in Molecular Biology ISBN: 9781617792694
Poly(ADP-ribose) polymerases have been linked to several cellular functions, most of which being mediated through the dynamics of poly(ADP-ribose) (pADPr). In several pathways, pADPr is the effector molecule that regulates cellular signaling and dict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c54220ef495f20c8bd35984c69b1fbc
https://europepmc.org/articles/PMC4399804/
https://europepmc.org/articles/PMC4399804/