Nanoscopic distribution of VAChT and VGLUT3 in striatal cholinergic varicosities suggests colocalization and segregation of the two transporters in synaptic vesicles

Autor: Paola Cristofari, Mazarine Desplanque, Odile Poirel, Alison Hébert, Sylvie Dumas, Etienne Herzog, Lydia Danglot, David Geny, Jean-François Gilles, Audrey Geeverding, Susanne Bolte, Alexis Canette, Michaël Trichet, Véronique Fabre, Stéphanie Daumas, Nicolas Pietrancosta, Salah El Mestikawy, Véronique Bernard

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Striatal cholinergic interneurons (CINs) use acetylcholine (ACh) and glutamate (Glut) to regulate the striatal network since they express vesicular transporters for ACh (VAChT) and Glut (VGLUT3). However, whether ACh and Glut are released simultaneou

Externí odkaz: https://doaj.org/article/67712e7c8fb74b11905624c392edde09

bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity of pigmentation in Drosophila melanogaster.

Autor: Sandra De Castro, Frédérique Peronnet, Jean-François Gilles, Emmanuèle Mouchel-Vielh, Jean-Michel Gibert

Publikováno v: PLoS Genetics, Vol 14, Iss 8, p e1007573 (2018)

Drosophila body pigmentation has emerged as a major Evo-Devo model. Using two Drosophila melanogaster lines, Dark and Pale, selected from a natural population, we analyse here the interaction between genetic variation and environmental factors to pro

Externí odkaz: https://doaj.org/article/c2971d80e62b42fbbb6bfe5425e5eec4

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum

Autor: Betuing, Katleen Pinchaud, Chloé Masson, Baptiste Dayre, Coline Mounier, Jean-François Gilles, Peter Vanhoutte, Jocelyne Caboche, Sandrine

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11001

Cholesterol metabolism dysregulation is associated with several neurological disorders. In Huntington’s disease (HD), several enzymes involved in cholesterol metabolism are downregulated, among which the neuronal cholesterol 24-hydroxylase, CYP46A1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::5366557f72e06888a6af2954689383d4

Actomyosin contractility in olfactory placode neurons opens the skin epithelium to form the zebrafish nostril

Autor: Marion Baraban, Clara Gordillo Pi, Isabelle Bonnet, Jean-François Gilles, Camille Lejeune, Mélody Cabrera, Florian Tep, Marie Anne Breau

Publikováno v: Developmental Cell. 58:361-375.e5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7db8698a25b73470f9b6283fd2d2cee
https://doi.org/10.1016/j.devcel.2023.02.001

Cytotoxic BODIPY-Appended Half-Sandwich Iridium(III) Complex Forms Protein Adducts and Induces ER Stress

Autor: Jean-François Gilles, Anthi Karaiskou, Robin Ramos, Romain Morichon, Benoit Caron, Candice Botuha, Joëlle Sobczak-Thépot, Cédric Przybylski, Michèle Salmain

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (22), pp.16675-16686. ⟨10.1021/acs.jmedchem.1c01335⟩
Journal of Medicinal Chemistry, 2021, 64 (22), pp.16675-16686. ⟨10.1021/acs.jmedchem.1c01335⟩

International audience; Half-sandwich complexes of iridium(III) are currently being developed as anticancer drug candidates. In this context, we introduce IrBDP for which the C^N chelating phenyloxazoline ligand carries a fluorescent and lipophilic B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b965ee4ed424115ae3df51e705d574f
https://hal.sorbonne-universite.fr/hal-03498836