Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jean-François Gaucher"'
Publikováno v:
Molecules, Vol 26, Iss 22, p 6759 (2021)
The vascular endothelial growth factor (VEGF) family of cytokines plays a key role in vasculogenesis, angiogenesis, and lymphangiogenesis. VEGF-A is the main member of this family, alongside placental growth factor (PlGF), VEGF-B/C/D in mammals, and
Externí odkaz:
https://doaj.org/article/5834be487b454718a4c6412d723aef0f
Autor:
Jean-François Gaucher, Marie Reille-Seroussi, Nathalie Gagey-Eilstein, Sylvain Broussy, Pascale Coric, Bili Seijo, Marie-Bernard Lascombe, Benoit Gautier, Wang-Quing Liu, Florent Huguenot, Nicolas Inguimbert, Serge Bouaziz, Michel Vidal, Isabelle Broutin
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167755 (2016)
Angiogenesis is tightly regulated through the binding of vascular endothelial growth factors (VEGFs) to their receptors (VEGFRs). In this context, we showed that human VEGFR1 domain 2 crystallizes in the presence of Zn2+, Co2+ or Cu2+ as a dimer that
Externí odkaz:
https://doaj.org/article/945d9e856baa4145be209985052c44c6
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 28(48)
Macrocyclization constraints are widely used in the design of protein ligands to stabilize their bioactive conformation and increase their affinities. However, the resulting changes in binding entropy can be puzzling and uncorrelated to affinity gain
Publikováno v:
Molecules, Vol 26, Iss 6759, p 6759 (2021)
Molecules
Molecules
The vascular endothelial growth factor (VEGF) family of cytokines plays a key role in vasculogenesis, angiogenesis, and lymphangiogenesis. VEGF-A is the main member of this family, alongside placental growth factor (PlGF), VEGF-B/C/D in mammals, and
Autor:
Marylise Hebert-Schuster, Edouard Lecarpentier, Kelly Pons, Laurence Lecomte-Raclet, Stéphanie Descroix, Jean Guibourdenche, Lucile Alexandre, Laura Trapiella-Alfonso, Simon Dumas, Lucie Huart, Laurent Malaquin, Camille Fraichard, Isabelle Broutin, Thierry Fournier, Jean-François Gaucher, Michel Vidal, Nathalie Gagey-Eilstein, Vassilis Tsatsaris
Publikováno v:
Hypertension
Hypertension, 2019, 74 (1), pp.145-153. ⟨10.1161/HYPERTENSIONAHA.118.12380⟩
Hypertension, American Heart Association, 2019, 74 (1), pp.145-153. ⟨10.1161/HYPERTENSIONAHA.118.12380⟩
Hypertension, 2019, 74 (1), pp.145-153. ⟨10.1161/HYPERTENSIONAHA.118.12380⟩
Hypertension, American Heart Association, 2019, 74 (1), pp.145-153. ⟨10.1161/HYPERTENSIONAHA.118.12380⟩
International audience; Preeclampsia is a hypertensive pregnancy disease associated with a massive increase in sFlt-1 (soluble form of the vascular endothelial growth factor 1) in the maternal circulation, responsible for angiogenic imbalance and end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d605afc1336da298df8f363930f041c3
https://hal.science/hal-02343967
https://hal.science/hal-02343967
Autor:
Isabelle Broutin, Michel Vidal, Sylvain Broussy, Jean-François Gaucher, Marie Reille-Seroussi, Laure-Anne Cussac
Publikováno v:
Analytical Biochemistry
Analytical Biochemistry, Elsevier Masson, 2017, 530, pp.107-112. ⟨10.1016/j.ab.2017.05.004⟩
Analytical Biochemistry, Elsevier Masson, 2017, 530, pp.107-112. ⟨10.1016/j.ab.2017.05.004⟩
The VEGFR1 has been shown to play a role in the regulation of angiogenesis, and has therefore been associated to several pathologies. In order to extend our toolbox of screening methods for the identification of compounds disrupting the VEGF receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d3731526aed4b813af2c90e80820a2
https://hal.archives-ouvertes.fr/hal-02519565
https://hal.archives-ouvertes.fr/hal-02519565
Autor:
Nathalie Gagey-Eilstein, Sylvain Broussy, Jean-François Gaucher, Isabelle Broutin, Michel Vidal, Marie Reille-Seroussi, Claudia Desole, Franck Brachet
Publikováno v:
Biochemistry
Biochemistry, American Chemical Society, 2015, 54 (33), pp.5147-5156. ⟨10.1021/acs.biochem.5b00722⟩
Biochemistry, American Chemical Society, 2015, 54 (33), pp.5147-5156. ⟨10.1021/acs.biochem.5b00722⟩
The v114* cyclic peptide has been identified as a tight vascular endothelial growth factor (VEGF) ligand. Here we report on the use of isothermal titration calorimetry (ITC), 96-well plate competition assay, and circular dichroism (CD) to explore the
Autor:
Suet Mui, Anne Houdusse, Elena B. Krementsova, Carolyn Cohen, Jean-François Gaucher, Kathleen M. Trybus
Publikováno v:
Proceedings of the National Academy of Sciences. 103:19326-19331
A 2.5-Å resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. The C-terminal lobe of each CaM adopts a semi-open conformation that grips the fi
Autor:
Huixiong Chen, Marie-Claude Fournie-Zaluski, Mohamed Selkti, Bernard-Pierre Roques, Alain Tomas, Thierry Prangé, Jean-François Gaucher
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 59:1200-1205
A new alpha-aminophosphinic compound able to inhibit both zinc-containing exopeptidases and endopeptidases has been crystallized with TLN as a model in order to investigate the mode of zinc recognition by the phosphinic moiety and to evaluate the pot
Publikováno v:
European Journal of Biochemistry. 267:1323-1329
A previous mutational analysis of erabutoxin a (Ea), a curaremimetic toxin from sea snake venom, showed that the substitutions S8G and S8T caused, respectively, 176-fold and 780-fold affinity decreases for the nicotinic acetylcholine receptor (AchR).