Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jean-François Desjardins"'
Autor:
Lotte Vanherle, Darcy Lidington, Franziska E. Uhl, Saskia Steiner, Stefania Vassallo, Cecilia Skoug, Joao M.N. Duarte, Sangeetha Ramu, Lena Uller, Jean-François Desjardins, Kim A. Connelly, Steffen-Sebastian Bolz, Anja Meissner
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104384- (2022)
Summary: Background: Cognitive impairment is a serious comorbidity in heart failure patients, but effective therapies are lacking. We investigated the mechanisms that alter hippocampal neurons following myocardial infarction (MI). Methods: MI was ind
Externí odkaz:
https://doaj.org/article/e8c849e59b7542508bc162f64d7699da
Autor:
Kim A. Connelly, Yanling Zhang, Jean-François Desjardins, Linda Nghiem, Aylin Visram, Sri N. Batchu, Verra G. Yerra, Golam Kabir, Kerri Thai, Andrew Advani, Richard E. Gilbert
Publikováno v:
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-11 (2020)
Abstract Background and aims Sodium–glucose linked cotransporter-2 (SGLT2) inhibitors reduce the likelihood of hospitalization for heart failure and cardiovascular death in both diabetic and non-diabetic individuals with reduced ejection fraction h
Externí odkaz:
https://doaj.org/article/4b4ae13147404daba5ca192e434d3681
Autor:
Kim A. Connelly, MBBS, PhD, Yanling Zhang, MD, Aylin Visram, BSc, Andrew Advani, BSc, MBChB, PhD, Sri N. Batchu, PhD, Jean-François Desjardins, MSc, Kerri Thai, BSc, Richard E. Gilbert, MBBS, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 1, Pp 27-37 (2019)
Summary: Recent studies send an unambiguous signal that the class of agents known as sodium-glucose–linked co-transporter-2 inhibitors (SGLT2i) prevent heart failure hospitalization in patients with type 2 diabetes. However, the mechanisms remain u
Externí odkaz:
https://doaj.org/article/47e40106a91e43e1abc3a180bfa9e722
Publikováno v:
Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-13 (2018)
Abstract Background Inhibiting both type 1 and 2 sodium–glucose linked cotransporter (SGLT1/2) offers the potential to not only increase glucosuria beyond that seen with selective SGLT2 inhibition alone but to reduce glucose absorption from the gut
Externí odkaz:
https://doaj.org/article/d68f6091161a4bff8438d79f3ae7c14a
Autor:
Loïs S Miraucourt, Jennifer Tsui, Delphine Gobert, Jean-François Desjardins, Anne Schohl, Mari Sild, Perry Spratt, Annie Castonguay, Yves De Koninck, Nicholas Marsh-Armstrong, Paul W Wiseman, Edward S Ruthazer
Publikováno v:
eLife, Vol 5 (2016)
Type 1 cannabinoid receptors (CB1Rs) are widely expressed in the vertebrate retina, but the role of endocannabinoids in vision is not fully understood. Here, we identified a novel mechanism underlying a CB1R-mediated increase in retinal ganglion cell
Externí odkaz:
https://doaj.org/article/c2fa602935ed4280aa687251b41efb0a
Autor:
Anne Schohl, Annie Castonguay, Perry W.E. Spratt, Edward S. Ruthazer, Jennifer Tsui, Loïs S. Miraucourt, Paul W. Wiseman, Jean François Desjardins, Yves De Koninck, Nicholas Marsh-Armstrong, Mari Sild, Delphine Gobert
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Type 1 cannabinoid receptors (CB1Rs) are widely expressed in the vertebrate retina, but the role of endocannabinoids in vision is not fully understood. Here, we identified a novel mechanism underlying a CB1R-mediated increase in retinal ganglion cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc38389a01f2dbeae9a7d0c3031317e
https://pubmed.ncbi.nlm.nih.gov/27501334
https://pubmed.ncbi.nlm.nih.gov/27501334
Publikováno v:
Biophysical Journal. 110(3)
Protein oligomerization is crucial for cellular regulation. Various methods have been used to study the oligomerization of membrane proteins and multimeric channels including single molecule step photobleaching subunit counting. However, the membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fcb263546b322f10a41624d9c27a20
Autor:
Philippe Seguin, Jean-Pierre Campion, Anne Bouix, Mireille Desille, Bruno Clément, Yves Lebreton, Yannick Mallédant, Agnès Joly, Jeanne Desbois, Véronique Sébille, Stephan Mahler, Jean-François Desjardins, Benjamin Fremond
Publikováno v:
Critical Care Medicine. 30:658-663
To analyze the effects of an extracorporeal bioartificial liver containing alginate bead-entrapped hepatocytes on pigs with ischemia-induced acute hepatic failure.Prospective animal study.University and INSERM laboratory.Fifteen Large White/Pietrin f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1fa65d5c80a8cb109f2ba76dfac067c
https://doi.org/10.1097/00003246-200203000-00027
https://doi.org/10.1097/00003246-200203000-00027
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 80:218-225
Although the influence of the adrenergic system has been studied in the presence of heart failure, controversies still exist. Since cyclooxygenase derivatives appear to modulate coronary and cardiac adaptation in the failing heart, we hypothesized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f16dbbe8870132eb2d8b9eb3bf01dc
https://doi.org/10.1139/y02-042
https://doi.org/10.1139/y02-042
Autor:
Robert A Civitarese, Ilana Talior-Volodarsky, Melissa Mitchell, Jean-François Desjardins, Golam Kabir, Donald Gullberg, Christopher A McCulloch, Kim A Connelly
Publikováno v:
Circulation. 130
BACKGROUND: Integrins, transmembrane receptors, play crucial roles in diverse cellular and developmental processes due to critical interactions with the extracellular matrix (ECM). During fetal development and towards adulthood, heart growth and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2bc4ca33d209f13cac884438a474b5
https://doi.org/10.1161/circ.130.suppl_2.17939
https://doi.org/10.1161/circ.130.suppl_2.17939