Výsledky vyhledávání - "Jean-François Bourge"

Glycoprotein 170 Induces Platelet-Activating Factor Receptor Membrane Expression and Confers Tumor Cell Hypersensitivity to NK-Dependent Cell Lysis

Autor: Christina Fleet, Yves Denizot, Jean-François Bourge, Philippe Leboulch, Rob Pawliuk, François Sigaux, Christian Berthou, Eugene Michel, Daniela Geromin, Annie Soulié, Marilyne Sasportes

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2004, 172 (6), pp.3604-11

Multidrug resistance (MDR) confers resistance to anticancer drugs and reduces therapeutic efficiency. It is often characterized by the expression of the MDR1 gene product P-glycoprotein (or gp170) at the membrane of tumor cells. To further propose a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270b879b3df53cb7f8ed1eb895e01a5e
https://doi.org/10.4049/jimmunol.172.6.3604

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Interferon-γ–induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis

Autor: Marilyne Sasportes, François Sigaux, Christian Berthou, Yuehe Zhang, Y. Denizot, Jean-François Bourge, Annie Soulié, Daniela Geromin

Publikováno v: Blood. 95:2329-2336

Perforin is known to display a membranolytic activity on tumor cells. Nevertheless, perforin release during natural killer (NK)–cell activation is not sufficient to induce membrane target-cell damage. On the basis of the ability of perforin to inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1dd474bf2ea2d9b1fb6746d2e52982e
https://doi.org/10.1182/blood.v95.7.2329

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Increased adhesion of the promyelocytic leukaemia cell line, NB4, to fibronectin and thrombospondin upon all-trans-retinoic acid treatment

Autor: Chantal Legrand, Myriem Touhami, Jean-François Bourge

Publikováno v: British Journal of Haematology. 104:706-714

We have evaluated the effects of all-trans-retinoic acid (RA) on the adhesion of the human promyelocytic cell line NB4 to various components of the extracellular matrix. NB4 cells, radiolabelled with 111Indium, showed a 2–3-fold increase (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fce9a169792608272b5a30d59d29cec0
https://doi.org/10.1046/j.1365-2141.1999.01235.x

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Down-regulation of Human Granzyme B Expression by Glucocorticoids

Autor: Jean-François Bourge, Marilyne Sasportes, Pascale Paul, A. Wargnier, François Sigaux, S Legros-Maida, Clotilde Lafaurie

Publikováno v: Journal of Biological Chemistry. 273:35326-35331

The serine protease granzyme B is an essential component of the granule exocytosis pathway, a major apoptotic mechanism used by cytotoxic T lymphocytes and natural killer cells to induce target cell apoptosis. Granzyme B gene transcription is induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e7e44097dd7f9f2ffe7b1a4115f39cc
https://doi.org/10.1074/jbc.273.52.35326

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Human foamy virus infection activates class I major histocompatibility complex antigen expression

Autor: Sandrine Colas, Pascale Paul, Rodica Emanoil-Ravier, Janine Wybier, Mounira K. Chelbi-Alix, Jean-François Bourge

Publikováno v: Journal of General Virology. 76:661-667

We examined the effect of human foamy virus (HFV) infection on the expression of human major histocompatibility complex molecules. Our data show that in vitro HFV infection of U373-MG glioblastoma cells results in increased expression of class I huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed75c9f6fd035068f45fdd1fb1fbfe7
https://doi.org/10.1099/0022-1317-76-3-661

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Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression

Autor: Philippe Kourilsky, Pascale Paul, Helene Zinszner, Odile Blanchet, Jean Dausset, Jean-François Bourge, Laurent Degos, Alain Israel

Publikováno v: Proceedings of the National Academy of Sciences. 89:3488-3492

Class I antigens encoded in the major histocompatibility complex (MHC) (HLA in man, H-2 in the mouse) play a key role in the recognition of target cells by cytolytic T lymphocytes. Tumor cells frequently do not express class I MHC molecules, which st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f718110fa87cf0182765c8bf6a379780
https://doi.org/10.1073/pnas.89.8.3488

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DNA binding of regulatory factors interacting with MHC-class-I gene enhancer correlates with MHC-class-I transcriptional level in class-I-defective cell lines

Autor: Laurent Degos, Helene Zinszner, Pascale Paul, Z. Tatari, Odile Blanchet, Jean-François Bourge

Publikováno v: International Journal of Cancer. 47:138-145

Tumor cells frequently show a lack of surface class-I major histocompatibility complex (MHC) antigen expression. These molecules are key recognition structures for immune rejection of tumor cells and their absence at the surface of tumor cells could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f8486c087062a9d8dd0625f176a95a
https://doi.org/10.1002/ijc.2910470725

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Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation

Autor: S Legros-Maida, Jean-François Bourge, Rémy Bosselut, A. Wargnier, C J Ghysdael, Pascale Paul, C Lafaurie, M. Sasportes

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 92(15)

Granzyme B serine protease is found in the granules of activated cytotoxic T cells and in natural and lymphokine-activated killer cells. This protease plays a critical role in the rapid induction of target cell DNA fragmentation. The DNA regulatory e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e3e31ce81cbd6cb63d59cb8602e86b
https://pubmed.ncbi.nlm.nih.gov/7624346

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A promoter element of the human serine esterase granzyme B gene controls specific transcription in activated T cells

Autor: Pascale Paul, A. Wargnier, Jean-François Bourge, M. Sasportes, Patrick Haddad

Publikováno v: European journal of immunology. 23(3)

The human granzyme B gene encodes a serine protease expressed specifically in cytoplasmic granules of cytotoxic T lymphocytes, released upon effector-target cell interaction. Previous studies have shown that granzyme B mRNA was induced in T lymphocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462fce53acfc8d139d0b9f815a86338b
https://pubmed.ncbi.nlm.nih.gov/8449211

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