Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jean-François Boisvieux"'
Autor:
Cécile André, Pierre Vincens, Jean-François Boisvieux, Serge A. Hazout, Jean-Paul Chevrolat, Laurent Buffat
Publikováno v:
Bioinformatics. 14:715-725
MOTIVATION: Complete genomic sequences will become available in the future. New methods to deal with very large sequences (sizes beyond 100 kb) efficiently are required. One of the main aims of such work is to increase our understanding of genome org
Publikováno v:
Artificial Intelligence in Medicine. 7:155-177
Monitoring patients hospitalized in hemato-oncology departments to undergo clinical protocols of therapy is a complex task. The main difficulty arises in the management of the oncology protocol as well as in the management of critical episodes of acu
Autor:
Jean-François Boisvieux, Salomon Ammar, Jean-Louis Golmard, Jean-Paul Chevrolat, Roland Jouvent
Publikováno v:
Artificial intelligence in medicine. 14(3)
In this paper Bayesian networks modelling is applied to a multidimensional model of depression. The characterization of the probabilistic model exploits expert knowledge to associate latent concentrations of neurotransmitters and symptoms. An evoluti
Publikováno v:
Bioinformatics. 17:196-197
Summary: MOSAIC is a set of tools for the segmentation of multiple aligned DNA sequences into homogeneous zones. The segmentation is based on the distribution of mutational events along the alignment. As an example, the analysis of one repeated seque
Publikováno v:
Journal of Pharmaceutical Sciences. 71:297-302
A two-compartment model with time lag is proposed to describe the pharmacokinetics of drugs subject to enterohepatic circulation. The basic model, including two compartments for body and GI tract, respectively, with elimination occurring from both co
Publikováno v:
Mathematical Biosciences. 58:19-25
The purpose of this paper is to show that for most of the compartment models used in pharmacokinetics, when initial conditions are zero except in one compartment, the time course of the corresponding state variable is monotonic decreasing. This state
Autor:
Alain Venot, Michelle Peignoux, Jean-Pierre Benhamou, Didier Lebrec, Jean-François Boisvieux, Jean-Louis Steimer
Publikováno v:
International Journal of Bio-Medical Computing. 10:331-340
In order to perform a quantification of the hepatic RES function, a mathematical model of the colloids phagocytosis was constructed and validated in normal and partially hepatectomised rats. The experimental design consisted of the collection of succ
Publikováno v:
Medical Informatics Europe 81 ISBN: 9783540105688
The determination of interindividual dosage regimen is not easy for drugs presenting toxicity risks and a large interpatient variability, such as lithium does. In that case two methods, using respectively the renal clearance and the 24-hour serum lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d9a4a26331f993e5662fd65a180508
https://doi.org/10.1007/978-3-642-93169-7_82
https://doi.org/10.1007/978-3-642-93169-7_82
Publikováno v:
Drug metabolism reviews. 15(1-2)
Individual pharmacokinetic parameters can be viewed as independent realizations of a random variable. The probability density function of the variable is assumed to be specified by its first two moments (mean vector and covariance matrix), and these