Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jean-Frédéric Westphal"'
Autor:
Jean Frédéric Westphal
Publikováno v:
British Journal of Clinical Pharmacology. 50:285-295
The oxidative phase of the biotransformation of drugs is a function of hepatic or intestinal cytochromes P-450, also called the mixed-function oxidase system. Three families of cytochromes – CYP1, CYP2, and CYP3 – perform the oxidative metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53ecab9f5b20466dbaa8a36daf1a2449
https://doi.org/10.1046/j.1365-2125.2000.00261.x
https://doi.org/10.1046/j.1365-2125.2000.00261.x
Autor:
J.M. Brogard, Jean-Frédéric Westphal
Publikováno v:
Drugs. 57:81-91
Initial therapy of acute cholecystitis and cholangitis is directed towards general support of the patient, including fluid and electrolyte replacement, correction of metabolic imbalances and antibacterial therapy. Factors affecting the efficacy of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5157e87c2177d19219869a4989d160e4
https://doi.org/10.2165/00003495-199957010-00007
https://doi.org/10.2165/00003495-199957010-00007
Autor:
Jean-Frédéric Westphal, J.M. Brogard
Publikováno v:
Drug Safety. 17:47-73
Cirrhosis encompasses a range of pathophysiological changes that may alter drug disposition. Drugs that are dependent primarily on the liver for their systemic clearance are more likely to be subject to reduced elimination and subsequent accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da4203e990aa1366ea64c7713813299
https://doi.org/10.2165/00002018-199717010-00004
https://doi.org/10.2165/00002018-199717010-00004
Autor:
J.M. Brogard, Jean-Frédéric Westphal
Publikováno v:
Clinical Pharmacokinetics. 24:46-58
Liver disease may produce significant, albeit highly variable, effects on the pharmacokinetic behaviour of antibiotics in serum. Drug disposition may be altered through several pathophysiological mechanisms including reduced hepatobiliary clearance,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0909d91f359a8c14e99bf5c3cfd3800f
https://doi.org/10.2165/00003088-199324010-00004
https://doi.org/10.2165/00003088-199324010-00004
Publikováno v:
Pharmacoepidemiology and drug safety. 20(2)
Purpose Some studies have shown that making practice guidelines accessible to physicians when they are making clinical decisions could improve prescribing practices. The aim of the study was to assess the benefit of impact on physician adherence of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3ae7738ba82f8b45a3f423ce6c3c8e
https://pubmed.ncbi.nlm.nih.gov/21254287
https://pubmed.ncbi.nlm.nih.gov/21254287
Publikováno v:
Journal of Pharmaceutical Sciences. 81:802-807
We have developed a specific numerical deconvolution program for the Apple Macintosh microcomputer. After comparison with other methods, we used the program to evaluate the influence of nifedipine on the absorption and bioavailability of amoxicillin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f534118cb2efc7b80396a8c40e59f09e
https://doi.org/10.1002/jps.2600810816
https://doi.org/10.1002/jps.2600810816
Publikováno v:
Presse medicale (Paris, France : 1983). 32(24)
DRUG-RELATED IATROGENIC NOSOCOMIAL ILLNESS: Remains a matter of concern in the public health area. Responsibility of hospitals is challenged by the ever increasing number of patients' claims. Dysfunction in the drug-prescribing and delivery system ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5855b52d1f647e9ff8e200a4326ea258
https://pubmed.ncbi.nlm.nih.gov/12947748
https://pubmed.ncbi.nlm.nih.gov/12947748
Publikováno v:
Clinical pharmacology and therapeutics. 57(3)
Intestinal absorption of beta-lactam antibiotics has been shown to use the dipeptide carrier system. In vitro experiments have established that the efficiency of uptake by enterocytes depends on an inwardly directed proton gradient--dipeptides and be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0266b07bd4001cf82f6ce174f1d49ab1
https://pubmed.ncbi.nlm.nih.gov/7697943
https://pubmed.ncbi.nlm.nih.gov/7697943
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 18(3)
Infection remains a leading cause of death among patients with cirrhosis of the liver. The high level of susceptibility of these patients to septicemic infection is accounted for by decreased reticuloendothelial function and impairment of several com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cec639f2e8abd7896553c9f9f728993
https://pubmed.ncbi.nlm.nih.gov/7888563
https://pubmed.ncbi.nlm.nih.gov/7888563
Publikováno v:
Clinical pharmacology and therapeutics. 54(5)
The hepatobiliary extraction profile of cefixime, a dianionic cephalosporin antibiotic, was studied in 10 patients, each of whom was provided with T-tube drainage of his or her common bile duct after cholecystectomy. After a single 200 mg oral dose,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cb784359c37bbf69135c4ec06a8e64
https://pubmed.ncbi.nlm.nih.gov/8222490
https://pubmed.ncbi.nlm.nih.gov/8222490