Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jean-Eric Charoin"'
Autor:
Jason Asher, Annabelle Lemenuel-Diot, Matthew Clay, David P Durham, Luis Mier-Y-Teran-Romero, Carlos J Arguello, Sebastien Jolivet, Diana Y Wong, Klaus Kuhlbusch, Barry Clinch, Jean-Eric Charoin
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010797 (2023)
To aid understanding of the effect of antiviral treatment on population-level influenza transmission, we used a novel pharmacokinetic-viral kinetic transmission model to test the correlation between nasal viral load and infectiousness, and to evaluat
Externí odkaz:
https://doaj.org/article/1c17ab378d404d0a8cdc24de5da057ef
Autor:
Lucy Hutchinson, Bernhard Steiert, Antoine Soubret, Jonathan Wagg, Alex Phipps, Richard Peck, Jean‐Eric Charoin, Benjamin Ribba
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 3, Pp 131-134 (2019)
Externí odkaz:
https://doaj.org/article/298df9502caf450dba5bd442766335d5
Autor:
Jun‐ichi Nishimura, Antoine Soubret, Noriko Arase, Simon Buatois, Masaki Hotta, Jean‐Eric Charoin, Yoshikazu Ito, Sasha Sreckovic, Hiroyuki Takamori, Christoph Bucher, Yasutaka Ueda, Jules Hernández‐Sánchez, Keisuke Gotanda, Gregor Jordan, Kenji Shinomiya, Julia Ramos, Jin Seok Kim, Jens Panse, Régis Peffault de Latour, Alexander Röth, Eiichi Morii, Hubert Schrezenmeier, Yoshitaka Isaka, Simona Sica, Yuzuru Kanakura, Sung‐Soo Yoon, Taroh Kinoshita, Ido Paz‐Priel, Alexandre Sostelly
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:904-915
Drug–target–drug complexes (DTDCs) are phenomena newly observed in patients who switch from the complement component 5 (C5) inhibitor eculizumab to crovalimab, a novel, anti-C5 antibody in development for paroxysmal nocturnal hemoglobinuria (PNH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f352fecae69e660b9f1196b2bb4809cc
https://doi.org/10.1002/cpt.2851
https://doi.org/10.1002/cpt.2851
Autor:
Volker Teichgräber, Pavel Pisa, Alex Phipps, Jean Eric Charoin, Jean Tessier, Christian Klein, Stefan Evers, Jehad Charo, Hans Peter Grimm, Tapan Nayak, Christophe Boetsch, Benjamin Ribba
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a35ccf90ebb95538b3b96ffdcec280c
https://doi.org/10.1158/1078-0432.22465131.v1
https://doi.org/10.1158/1078-0432.22465131.v1
Autor:
Volker Teichgräber, Pavel Pisa, Alex Phipps, Jean Eric Charoin, Jean Tessier, Christian Klein, Stefan Evers, Jehad Charo, Hans Peter Grimm, Tapan Nayak, Christophe Boetsch, Benjamin Ribba
Supplementary Figure S1: Left: CEA expression by immuno-histochemistry in the LS174T tumor mouse model: homogeneous cytoplasmic antigen distribution. Right: CEA expression in one of the treated patients (colorectal cancer): heterogeneous cytoplasmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b987aad8cb87c9dc01c6d5be388abbc
https://doi.org/10.1158/1078-0432.22465140
https://doi.org/10.1158/1078-0432.22465140
Autor:
Volker Teichgräber, Pavel Pisa, Alex Phipps, Jean Eric Charoin, Jean Tessier, Christian Klein, Stefan Evers, Jehad Charo, Hans Peter Grimm, Tapan Nayak, Christophe Boetsch, Benjamin Ribba
Purpose: Optimal dosing is critical for immunocytokine-based cancer immunotherapy to maximize efficacy and minimize toxicity. Cergutuzumab amunaleukin (CEA-IL2v) is a novel CEA-targeted immunocytokine. We set out to develop a mathematical model to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2556a1ba8acaa2fde530ba00d2a6d156
https://doi.org/10.1158/1078-0432.c.6525936
https://doi.org/10.1158/1078-0432.c.6525936
Autor:
Volker Teichgräber, Pavel Pisa, Alex Phipps, Jean Eric Charoin, Jean Tessier, Christian Klein, Stefan Evers, Jehad Charo, Hans Peter Grimm, Tapan Nayak, Christophe Boetsch, Benjamin Ribba
Supplemental Table S2: Model parameter estimates. For model equations, refer to supplemental material.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546194bedc8c55f6656385f52b67c758
https://doi.org/10.1158/1078-0432.22465122.v1
https://doi.org/10.1158/1078-0432.22465122.v1
Autor:
Jason Asher, Annabelle Lemenuel-Diot, Matthew Clay, David P. Durham, Luis Mier-y-Teran-Romero, Carlos J. Arguello, Sebastien Jolivet, Diana Y. Wong, Klaus Kuhlbusch, Barry Clinch, Jean-Eric Charoin
Publikováno v:
PLoS computational biology. 19(1)
To aid understanding of the effect of antiviral treatment on population-level influenza transmission, we used a novel pharmacokinetic–viral kinetic transmission model to test the correlation between nasal viral load and infectiousness, and to evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9bae03248c3ea971607e20b13fc3e5
https://pubmed.ncbi.nlm.nih.gov/36608108
https://pubmed.ncbi.nlm.nih.gov/36608108
Autor:
Bernhard Steiert, Alex Phipps, Jean-Eric Charoin, Benjamin Ribba, Antoine Soubret, Jonathan Wagg, Richard Peck, Lucy Hutchinson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 3, Pp 131-134 (2019)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Recent advances in machine learning (ML) have led to enthusiasm about its use throughout the biopharmaceutical industry. The ML methods can be applied to a wide range of problems and have the potential to revolutionize aspects of drug development. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74e95703a5cba18dafdfdc28f0937fc
https://doaj.org/article/298df9502caf450dba5bd442766335d5
https://doaj.org/article/298df9502caf450dba5bd442766335d5
Autor:
Annabelle Lemenuel-Diot, Barry Clinch, Stefan Frings, Jean Eric Charoin, Paul Boutry, Johann Laurent, Mathias Leddin, Aeron C. Hurt
Accurate prediction of COVID-19 cases can optimize clinical trial recruitment, inform mitigation strategies and facilitate rapid medication development. Here we present a country-specific, modified Susceptible, Exposed, Infectious, Removed (SEIR) mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d00033f26e26074fbd0c317ddfb0fd3
https://doi.org/10.1101/2020.11.23.20237404
https://doi.org/10.1101/2020.11.23.20237404