Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency

Autor: Mouad Alami, Jean-Daniel Brion, Pascal Bonnet, Abdallah Hamze, Nada Ibrahim, Pierre Colas, Jean-François Peyrat, Thomas Robert, Samir Messaoudi, Jérôme Bignon, Stéphane Bach, Béatrice Josselin, Hélène Levaique

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 199 (31), pp.112355. ⟨10.1016/j.ejmech.2020.112355⟩
European Journal of Medicinal Chemistry, 2020, 199 (31), pp.112355. ⟨10.1016/j.ejmech.2020.112355⟩

International audience; In this work, unique structure of flavopiridol analogs bearing thiosugars, amino acids and heterocyclic moieties tethered to the flavopiridol via thioether and amine bonds mainly on its C ring have been prepared. The analogs b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd8e4f320b04c9aaeb01d1f5e7b01da
https://hal.archives-ouvertes.fr/hal-03036489

Dichloridobis[(S)-2-hydroxypropionamide-κ2O,O′]manganese(II)

Autor: Alain Bekaert, Jean Daniel Brion, Bernard Viossat, Pascale Lemoine

Publikováno v: Acta Crystallographica Section E, Vol 64, Iss 3, Pp m471-m471 (2008)

In the title compound, [MnCl2(C3H7NO2)2], the MnII ion is bound to two Cl atoms and to four O atoms from two lactamide molecules which act as bidentate ligands, giving rise to a highly distorted octahedral coordination geometry. The axial positions a

Externí odkaz: https://doaj.org/article/f1f8e5e12a434b10b4230c6a92614ff5

Palladium-Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine-Containing Molecules at Room Temperature

Autor: Alain Wagner, Sébastien Delacroix, Stéphane Erb, Samir Messaoudi, Stéphanie Nicolaÿ, Mouâd Alami, Riyadh Ahmed Atto AL-Shuaeeb, Sergii Kolodych, Jean-Daniel Brion, Sarah Cianférani, Jean-Christophe Cintrat, Oleksandr Koniev

Publikováno v: Chemistry - A European Journal. 22:11365-11370

The third generation of aminobiphenyl palladacycle pre-catalyst "G3-Xantphos" enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee97e8f7e81132e53913087c6e72c1a7
https://doi.org/10.1002/chem.201602277

A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer

Autor: Ali Hachem, Mouad Alami, Timothée Naret, Jérôme Bignon, Ali Khalaf, Tourin Bzeih, Abdallah Hamze, Nada Jaber, Jean-Daniel Brion

Publikováno v: Chemical Communications. 52:13027-13030

A convergent and effective synthesis of 3-aryl-indoles, 2,3-diaryl indoles, and (1-arylvinyl)carbazoles from a one-pot sequence involving the coupling of N-tosylhydrazones with ortho-nitro-haloarenes followed by a cyclization has been developed. Comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a511d7eed3afab2188495940a1dfe75
https://doi.org/10.1039/c6cc07666a

Transition-Metal-Free Synthesis of Polysubstituted Cyclopropane Derivatives fromN-Tosylhydrazones and their Cytotoxic Activities

Autor: Marie Lawson, Jean-Daniel Brion, Jérôme Bignon, Mouad Alami, Abdallah Hamze

Publikováno v: Asian Journal of Organic Chemistry. 4:1144-1154

We describe a general method for metal-free cyclopropanation of different electron-deficient olefins with N-tosylhydrazones as a source of diazo compounds. This method works with N-tosylhydrazones derived from acetophenones or benzophenones. This rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e12a9d859eee68e16a6711b0237647a
https://doi.org/10.1002/ajoc.201500289