Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jean-Damien Charrier"'
Autor:
Somhairle Maccormick, Steven Durrant, Anisa Nizarali Virani, Christopher John Davis, Steve Young, Golec Julian M C, Storck Pierre Henri, Philip Michael Reaper, David Kay, John Pollard, Michael O'donnell, Heather Twin, Jean-Damien Charrier, Peter Littlewood, Matthew R. Griffiths, Joanne Pinder, Ronald Knegtel
Publikováno v:
Journal of medicinal chemistry. 62(11)
The DNA damage response (DDR) is a DNA damage surveillance and repair mechanism that can limit the effectiveness of radiotherapy and DNA-damaging chemotherapy, commonly used treatment modalities in cancer. Two related kinases, ataxia telangiectasia m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236bb1d7274297437c1461393876f89b
https://pubmed.ncbi.nlm.nih.gov/31074988
https://pubmed.ncbi.nlm.nih.gov/31074988
Publikováno v:
Tetrahedron. 71:1515-1522
A novel approach towards the production of diverse sets of diaminopyrimidines through sequential S N Ar reactions is reported. The readily prepared 2-chloro-4-tetrafluorophenoxypyrymidine reacts regioselectively with amines at the C-2 position. The t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07792fde39248af014b5b206b5598dbe
https://doi.org/10.1016/j.tet.2015.01.043
https://doi.org/10.1016/j.tet.2015.01.043
2-Chloro-4-tetrafluorophenoxypyrimidine: a versatile reagent for C-2 prior to C-4 functionalizations
Publikováno v:
Tetrahedron Letters. 57:1882-1884
A novel synthetic route to 2,4-functionalized pyrimidines is reported. The approach uses 2-chloro-4-tetrafluorophenoxypyrimidine, that enables sequential palladium catalyzed functionalization at the pyrimidine C-2 position, followed by S N Ar displac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d575b9b3fb1ff46d2f876db3bc33ee
https://doi.org/10.1016/j.tetlet.2016.03.057
https://doi.org/10.1016/j.tetlet.2016.03.057
Autor:
Ronald Knegtel, Jean-Damien Charrier
Publikováno v:
Expert Opinion on Drug Discovery. 8:369-381
ITK is a member of the Tec family of nonreceptor protein tyrosine kinases that plays a central role in T-cell signaling. Its inhibition is seen as an attractive approach to the treatment of immune-mediated disorders. Insight into the function of ITK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a73cc712f5a7a5bbdb9633b1c7322
https://doi.org/10.1517/17460441.2013.769520
https://doi.org/10.1517/17460441.2013.769520
Publikováno v:
ChemInform. 47
2,4-Substituted pyrimidines are prepared by C-2 functionalization of 2-chloro-4-tetrafluorophenoxypyrimidine (I) by cross-coupling reactions followed by SNAr displacement at C-4 position with a variety of amines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb560acf6c63fc716fdbd740aac3234c
https://doi.org/10.1002/chin.201632170
https://doi.org/10.1002/chin.201632170
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:485-488
A novel type of caspase inhibitor prodrug that improves systemic exposure after oral administration in rats has been designed. Such a prodrug, based on a 6,6a-dihydrofuro[3,2-d]oxazol-5(3aH)-one motif, has the advantage of rapidly liberating the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3527488be3b1919812fec21b8b40bed
https://doi.org/10.1016/j.bmcl.2011.10.102
https://doi.org/10.1016/j.bmcl.2011.10.102
Autor:
Paul S.H. Wang, Michael O'donnell, Alistair Rutherford, John Pollard, Jean-Damien Charrier, Somhairle Maccormick, Ronald Knegtel, Philip Michael Reaper, David Kay, Joanne Pinder, Steven Durrant, Michael Mortimore, Stephen Clinton Young, Golec Julian M C
Publikováno v:
Journal of Medicinal Chemistry. 54:2320-2330
DNA-damaging agents are among the most frequently used anticancer drugs. However, they provide only modest benefit in most cancers. This may be attributed to a genome maintenance network, the DNA damage response (DDR), that recognizes and repairs dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58e4f118a9c832e643b8ec56a190cfd
https://doi.org/10.1021/jm101488z
https://doi.org/10.1021/jm101488z
Publikováno v:
Tetrahedron Letters. 55:4853-4855
A convenient, single-step, efficient synthesis of benzimidazoles from esters and diamines is reported. The methodology uses an air stable form of trimethylaluminum referred to as DABAL-Me3 and is compatible with a wide range of functional groups, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c93edf9a69ea0106c3e9da19d28cc1ff
https://doi.org/10.1016/j.tetlet.2014.06.026
https://doi.org/10.1016/j.tetlet.2014.06.026
Autor:
John Pollard, Francesca Mazzei, Chau Mak, Damien Fraysse, Sanjay Patel, Sharn Ramaya, David Bebbington, John Studley, Joanne Pinder, Ronald Knegtel, Daniel Robinson, Andrew Miller, Francoise Pierard, Michael O'donnell, Alistair Rutherford, Jean-Damien Charrier, David Kay, Michael Mortimore, Simon Everitt, Hayley Binch, Golec Julian M C, James Westcott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3586-3592
The identification of a novel series of Aurora kinase inhibitors and exploitation of their SAR is described. Replacement of the initial quinazoline core with a pyrimidine scaffold and modification of substituents led to a series of very potent inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0925b30e50e9b61648460b5b023cd8ac
https://doi.org/10.1016/j.bmcl.2009.04.136
https://doi.org/10.1016/j.bmcl.2009.04.136
Publikováno v:
ChemInform. 46
2-Chloro-4-(2,3,5,6-tetrafluorophenoxy)pyrimidine (I) can be diaminated in a regioselective stepwise manner: first amination occurs at C-2, second amination at C-4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99f819de7fa2cb71cc8e73b5d74ca0c4
https://doi.org/10.1002/chin.201527219
https://doi.org/10.1002/chin.201527219