A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase

Autor: Frank Koenen, Hélène Dutartre, Gerhard Puerstinger, Pierre Kerkhofs, Johan Neyts, Bruno Canard, Matheus Froeyen, Jan Paeshuyse, Jean-Claude Teulade, Erik De Clercq, Piet Herdewijn, Pier Giovanni Baraldi, Carine Letellier, Robert Vrancken, Alain Gueiffier

Publikováno v: Antiviral Research
Antiviral Research, Elsevier Masson, 2009, 82 (3), pp.141-147. ⟨10.1016/j.antiviral.2009.02.192⟩
Antiviral Research, 2009, 82 (3), pp.141-147. ⟨10.1016/j.antiviral.2009.02.192⟩

[7-[3-(1,3-Benzodioxol-5-yl)propyl]-2-(2-furyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] (LZ37) was identified as a selective inhibitor of in vitro bovine viral diarrhea virus (BVDV) replication. The EC(50) values for inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846296bf2221dfddd9a05c353cf18b95
https://doi.org/10.1016/j.antiviral.2009.02.192

From the Particular Reactivity of 8-Iodoimidazo[1,2-a]pyridine towards Copper- and Palladium-Catalyzed Aminations

Autor: Cécile Enguehard-Gueiffier, Jean-Michel Chezal, Alain Gueiffier, Olivier Chavignon, Jean-Claude Teulade, Jean-Yves Kazock, Isabelle Thery

Publikováno v: Bulletin of the Chemical Society of Japan. 79:775-779

The reactivity of 8-iodoimidazo[1,2-a]pyridine towards copper- and palladium-catalyzed aminations is reported. The copper-based methodology led to the attempted coupling products in only poor yield...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80493d162a7a99e0c287e4c6d1601522
https://doi.org/10.1246/bcsj.79.775

Synthesis and in Vitro Cytotoxic Evaluation of New Derivatives of Pyrido[1,2-a]benzimidazolic Ring System: The Pyrido[1',2':1,2]imidazo[4,5-h]quinazolines

Autor: Jean-Michel Chezal, Olivier Chavignon, Yves Blache, Jean-Claude Teulade, Jean-Pierre Chapat, Marianne Dupuy, Frédéric Pinguet

Publikováno v: Chemical and Pharmaceutical Bulletin
Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 2001, 49, pp.1061-1065. ⟨10.1248/cpb.49.1061⟩

International audience; Access to the original series of pyrido[1',2':1,2]imidazo[4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some “N-C-N” bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c5e51461ac0aea7fa3511cf468fac1
https://doi.org/10.1248/cpb.49.1061

New Potential Antimalarial Agents. Synthesis and Biological Activities of Original Diaza-analogs of Phenanthrene

Autor: Mustofa Mustofa, Yves Blache, Ange Desire Yapi, Alexis Valentin, Jean-Pierre Chapat, Jean-Claude Teulade, Michèle Mallié, Olivier Chavignon

Publikováno v: Chemical and Pharmaceutical Bulletin. 48:1886-1889

Several diaza-analogs of phenanthrene derived from 3-amino, 5-amino, 6-amino, 8-aminoquinolines, and 5-aminoisoquinoline were prepared to evaluate their antiplasmodial activities. All compounds showed mild to good activitiy in vitro, both on a Nigeri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dc5ef2bc7ebec5474358eb444058b8
https://doi.org/10.1248/cpb.48.1886

Heterocyclic enaminones: Photochemical synthesis of 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-9-ones

Autor: Jean-Claude Teulade, Veronique Benezech, Mohammed Hichour, Yves Blache, Jean-Pierre Chapat, Marie-Eve Sinibaldi-Troin, Olivier Chavignon, Jean-Claude Gramain

Publikováno v: Tetrahedron. 55:1959-1970

The synthesis of 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-9-ones from arylenaminones is described. Two “routes” have been investigated: a radical process through a photochemical reaction, and a catalytic process through an arylpalladium complex.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f5890732ecd5c0dc542db5e858b8e07
https://doi.org/10.1016/s0040-4020(98)01212-5