Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Jean-Claude Labbé"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The canonical eukaryotic cell cycle ends with cytokinesis, which physically divides the mother cell in two and allows the cycle to resume in the newly individualized daughter cells. However, during germline development in nearly all metazoans, dividi
Externí odkaz:
https://doaj.org/article/b53bcc493dc34595911de22f49d00944
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006738 (2017)
Under replete growth conditions, abundant nutrient uptake leads to the systemic activation of insulin/IGF-1 signalling (IIS) and the promotion of stem cell growth/proliferation. Activated IIS can stimulate the ERK/MAPK pathway, the activation of whic
Externí odkaz:
https://doaj.org/article/08c26b2dfef64a11a6c17bef8254055b
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117656 (2015)
In the C. elegans embryo, formation of an antero-posterior axis of polarity relies on signaling by the conserved PAR proteins, which localize asymmetrically in two mutually exclusive groups at the embryonic cortex. Depletion of any PAR protein causes
Externí odkaz:
https://doaj.org/article/89edd10ac88843449f1b59c0141c5635
Autor:
Vincent Hyenne, Thierry Tremblay-Boudreault, Ramraj Velmurugan, Barth D Grant, Dinah Loerke, Jean-Claude Labbé
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35286 (2012)
In all organisms, cell polarity is fundamental for most aspects of cell physiology. In many species and cell types, it is controlled by the evolutionarily conserved PAR-3, PAR-6 and aPKC proteins, which are asymmetrically localized at the cell cortex
Externí odkaz:
https://doaj.org/article/ad97295a4f0246afb1c5f225e7b30105
Autor:
Ramya Singh, Jean-Claude Labbé, Abigail R Gerhold, Réda M Zellag, Yifan Zhao, Vincent Poupart
Publikováno v:
Molecular Biology of the Cell
Investigating the complex interactions between stem cells and their native environment requires an efficient means to image them in situ. Caenorhabditis elegans germline stem cells (GSCs) are distinctly accessible for intravital imaging; however, lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c468eabce22808bf4470caa722ef86df
https://doi.org/10.1091/mbc.e20-11-0716
https://doi.org/10.1091/mbc.e20-11-0716
To assess the antioxidant properties of lupeol, we first employed the fluorescent, ROS-sensitive dye dihydroethidium (DHE) to measure changes in the levels of ROS in vivo (Senchuk et al. 2018). This was done in either wild-type animals (N2) or isp-1(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f46690222f4424ccfab2bb8d37afbf8
Autor:
Jean-Claude Labbé, Ken C. Q. Nguyen, David H. Hall, Jack Bauer, Vincent Poupart, Eugénie Goupil
Publikováno v:
Development
The C. elegans germline is organized as a syncytium in which each germ cell possesses an intercellular bridge that is maintained by a stable actomyosin ring and connected to a common pool of cytoplasm, termed the rachis. How germ cells undergo cytoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06853b08fba9cfd6507f10caed017d15
https://europepmc.org/articles/PMC8327289/
https://europepmc.org/articles/PMC8327289/
Autor:
Thierry Lorca, Sylvain Roque, Suzanne Vigneron, Sushil Awal, Francisca Mechali, Jean-Claude Labbé, Anna Castro, Priya Amin
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2022, 41 (1), pp.1-14. ⟨10.1038/s41388-021-02068-x⟩
Oncogene, Nature Publishing Group, 2022, 41 (1), pp.1-14. ⟨10.1038/s41388-021-02068-x⟩
PP2A is a major serine/threonine phosphatase class involved in the regulation of cell signaling through the removal of protein phosphorylation. This class of phosphatases is comprised of different heterotrimeric complexes displaying distinct substrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa66ef01ad3db9b39b279f118839cb9
https://pubmed.ncbi.nlm.nih.gov/34686773
https://pubmed.ncbi.nlm.nih.gov/34686773
Autor:
Jean-Claude Labbé, Sylvain Roque, Francisca Mechali, Cindy Genoud, Suzanne Vigneron, Anna Castro, Thierry Lorca, Martin Cohen-Gonsaud, Gilles Labesse, Perle Robert, Perrine Goguet-Rubio, Phillipe Barthe
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23657-0⟩
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-23657-0⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23657-0⟩
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-23657-0⟩
Arpp19 is a potent PP2A-B55 inhibitor that regulates this phosphatase to ensure the stable phosphorylation of mitotic/meiotic substrates. At G2-M, Arpp19 is phosphorylated by the Greatwall kinase on S67. This phosphorylated Arpp19 form displays a hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2d0a3eff8c9c5b6bc8d2e1b44a63f9
https://hal-cnrs.archives-ouvertes.fr/hal-03263787
https://hal-cnrs.archives-ouvertes.fr/hal-03263787
Autor:
Jean-Claude Labbé, Yifan Zhao, Vincent Poupart, Abigail R Gerhold, Mohamed Réda Zellag, Ramya Singh
Investigating the complex interactions between stem cells and their native environment requires an efficient means to image them in situ. Caenorhabditis elegans germline stem cells (GSCs) are distinctly accessible for intravital imaging; however, lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2167e6e5bc3d27a2fd6fec9402b7cfa
https://doi.org/10.1101/2020.11.22.393272
https://doi.org/10.1101/2020.11.22.393272