Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jean-Claude Koffel"'
Publikováno v:
Journal of Liquid Chromatography. 18:2801-2812
A stereospecific high-performance liquid chromatographic method for the simultaneous determination of the four stereoisomers of 4-hydroxytertatolol, an active metabolite of tertatolol, in human and rat urine is described. The method is based on solid
Publikováno v:
Clinical Drug Investigation. 9:150-155
The objective of this study was to investigate the presence of stereoselective processes in the pharmacokinetics and metabolism of tertatolol in humans, using urinary excretion data. Six healthy male volunteers were given single 5mg oral doses of (+,
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 572:203-210
A stereospecific high-performance liquid chromatographic method for the quantification of (−)- and (+)-tertatolol in plasma and urine is described. The method involves solid-phase extraction followed by derivatization with S (+)-naphthylethylisocya
Publikováno v:
The Journal of pharmacy and pharmacology. 56(8)
Grapefruit juice can modify the pharmacokinetic parameters of many drugs, in particular simvastatin, an orally active cholesterol-lowering agent. The exact components in grapefruit juice responsible for drug interactions are not perfectly known. Howe
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 18(1)
Grapefruit juice is responsible for many drug interactions but the exact components involved in this interaction are not precisely known. Flavonoids and furocoumarin derivatives such as naringenin and bergamottin, respectively, could be involved in t
Autor:
Genevieve Ubeaud, Guy Freys, Bernadette Jacoberger, Louis Jung, Jean Claude Koffel, Thierry Pottecher
Plasma and epiploic-fat drug concentrations determined by high-performance liquid chromatography and fat penetration of pefloxacin and its metabolite (norfloxacin) given for antimicrobial prophylaxis were studied in patients scheduled for colorectal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f78ce94f3130052b7d4d8872d72928
https://europepmc.org/articles/PMC105426/
https://europepmc.org/articles/PMC105426/
Autor:
Jean-Claude Koffel, Louis Jung, Min-Jie Zhao, Marie-Claude Holtz, Céline Peter, Nathalie Hugenell
Publikováno v:
Journal of chromatography. B, Biomedical applications. 656(2)
A relatively rapid, inexpensive, sensitive and stereospecific gas chromatographic-mass spectrometric method was developed for the quantification of S(+) and R(-)-ibuprofen in human plasma. This method uses a commercially available internal standard a
Autor:
Alexis Gairard, Jean-Claude Koffel, T. Lave, Louis Jung, O. Crambes, B. Van Overloop, C. Efthymiopoulos
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 24(6)
1. Plasma concentrations of the two enantiomers of tertatolol were determined by gc/ms. Deuterium labelling of one of the tertatolol enantiomers was used for chiral discrimination. 2. No isotope effects were observed following simultaneous oral admin
Publikováno v:
Chemischer Informationsdienst. Organische Chemie. 1