Zobrazeno 1 - 2
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pro vyhledávání: '"Jean-Claude Jetha"'
Autor:
Cédric Martin, Nicolas Rodeville, Christine Moureou, Franck Muller, Samuel Tabet, Isabelle Cardinaud, Jean-Claude Jetha, Jean-Guy Boiteau
Publikováno v:
Organic Process Research & Development. 19:646-651
Herein, we report the kilogram-scale synthesis of CD08108, a novel MC1R agonist. This synthesis has been developed to produce the first batches of this compound for preclinical and clinical studies. Two amido couplings were used to synthesize the bac
Autor:
Mostapha Matrougui, Paul J. Schaeffer, Zsolt Bocskei, Janine Lorrain, Jean-Marc Herbert, Christopher N. Berry, Jean-Claude Jetha, Stephen E. O'Connor, Lassalle Gilbert, Jean-Michel Altenburger, Jean-Pascal Herault, Catherine Lunven, Daniel Galtier
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:1713-1730
SSR182289A 1 is the result of a rational optimisation process leading to an orally active thrombin inhibitor. The struc- ture incorporates an original 2-(acetylamino)-(1,1 0 -biphenyl)-3-sulfonyl N-terminal motif, a central l-Arg surrogate carrying a