Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Jean-Claude Guillemot"'
Autor:
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S. Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The drug AT-527 targets the SARS-CoV-2 replication machinery. Here the authors use Cryo-EM to show how AT-527 inhibits SARS-CoV-2 polymerase by acting as an immediate RNA chain terminator and stably binding in a NiRAN active-site pocket; impeding an
Externí odkaz:
https://doaj.org/article/10c0996a692f427a8bc1883d8ce5e61e
Autor:
Armelle Buzy, Camille Allain, John Harrington, Dominique Lesuisse, Vincent Mikol, David F. Bruhn, Aaron G. Maule, Jean-Claude Guillemot
Publikováno v:
ACS Omega, Vol 6, Iss 15, Pp 10288-10305 (2021)
Externí odkaz:
https://doaj.org/article/0d3dfcf32203481a995ff60786dae934
Autor:
Ho Sing Lo, Kenrie Pui Yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony K. N. Chan, Hayley Hei-Yin Cheung, Ka-Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis K. L. Chan, David S. C. Hui, Vincent C. T. Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, Wai-Lung Ng
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 792-802 (2021)
Externí odkaz:
https://doaj.org/article/c762182b6ed241e1a9a8500ceaadaf97
Autor:
Salvina Laura Tammaccaro, Philippe Prigent, Jean-Christophe Le Bail, Odette Dos-Santos, Laurent Dassencourt, Myriam Eskandar, Armelle Buzy, Olivier Venier, Jean-Claude Guillemot, Yaligara Veeranagouda, Michel Didier, Emmanuel Spanakis, Tokuwa Kanno, Matteo Cesaroni, Stephane Mathieu, Luc Canard, Alhassan Casse, Fanny Windenberger, Loreley Calvet, Laurence Noblet, Sukhvinder Sidhu, Laurent Debussche, Jurgen Moll, Iris Valtingojer
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 553 (2023)
KRASG12C is one of the most common mutations detected in non-small cell lung cancer (NSCLC) patients, and it is a marker of poor prognosis. The first FDA-approved KRASG12C inhibitors, sotorasib and adagrasib, have been an enormous breakthrough for pa
Externí odkaz:
https://doaj.org/article/7e2f740d0cd742fc8a87d89a6ecacddd
Autor:
Matthew J. Birket, Sophie Raibaud, Miriam Lettieri, Antony D. Adamson, Valerie Letang, Pauline Cervello, Nicolas Redon, Gwenaelle Ret, Sandra Viale, Bing Wang, Bruno Biton, Jean-Claude Guillemot, Vincent Mikol, John P. Leonard, Neil A. Hanley, Cecile Orsini, Jean-Michel Itier
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 380-393 (2019)
Summary: Here, we have used patient-derived induced pluripotent stem cell (iPSC) and gene-editing technology to study the cardiac-related molecular and functional consequences of mutations in GLA causing the lysosomal storage disorder Fabry disease (
Externí odkaz:
https://doaj.org/article/c2c19783b4b74745a6875cfbc1a18bb7
Autor:
Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1021 (2022)
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–ac
Externí odkaz:
https://doaj.org/article/d301b0071e384bba936c2d8ac80db4e5
Autor:
Johanna Escoubet, Mireille Kenigsberg, Murielle Derock, Veeranagouda Yaligara, Marie-Dominique Bock, Sandrine Roche, Florence Massey, Hélène de Foucauld, Charles Bettembourg, Anne Olivier, Antoine Berthemy, Joël Capdevielle, Richard Legoux, Eric Perret, Armelle Buzy, Pascale Chardenot, Valérie Destelle, Aurélie Leroy, Christophe Cahours, Sandrine Teixeira, Patrick Juvet, Pascal Gauthier, Michaël Leguet, Laurence Rocheteau-Beaujouan, Marie-Agnès Chatoux, Willy Deshayes, Margerie Clement, Mostafa Kabiri, Cécile Orsini, Vincent Mikol, Michel Didier, Jean-Claude Guillemot
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234780 (2020)
Obesity epidemic continues to spread and obesity rates are increasing in the world. In addition to public health effort to reduce obesity, there is a need to better understand the underlying biology to enable more effective treatment and the discover
Externí odkaz:
https://doaj.org/article/00b67697983c409c9b1c9415eaa96e89
Autor:
Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J. Snijder, Martijn J. van Hemert, Frank van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De Jonghe, Arnaud Marchand
Publikováno v:
Molecules, Vol 27, Iss 3, p 1052 (2022)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has led to a pandemic, that continues to be a huge public health burden. Despite the availability of vaccines, there is still a need for small-molecule
Externí odkaz:
https://doaj.org/article/e3ecdfeabd414d40b446f2e5c206a3fd
Autor:
Anthony Brureau, Véronique Blanchard-Bregeon, Catherine Pech, Stéphanie Hamon, Pascal Chaillou, Jean-Claude Guillemot, Pascal Barneoud, Philippe Bertrand, Laurent Pradier, Thomas Rooney, Nathalie Schussler
Publikováno v:
Neurobiology of Disease, Vol 104, Iss , Pp 73-84 (2017)
Accumulation of neurofilaments (NFs), the major constituents of the neuronal cytoskeleton, is a distinctive feature of neurological diseases and several studies have shown that soluble NFs can be detected in the cerebrospinal fluid (CSF) of patients
Externí odkaz:
https://doaj.org/article/67c0aa37b5994dcea00b57f71209cffa
Autor:
Camille de Cevins, Laure Delage, Maxime Batignes, Quentin Riller, Marine Luka, Anne Remaury, Boris Sorin, Tinhinane Fali, Cécile Masson, Bénédicte Hoareau, Catherine Meunier, Mélanie Parisot, Mohammed Zarhrate, Brieuc P. Pérot, Víctor García-Paredes, Francesco Carbone, Luc Canard, Charlotte Boussard, Etienne Crickx, Jean-Claude Guillemot, Marie-Louise Frémond, Bénédicte Neven, Galina Boldina, Franck Augé, Fischer Alain, Michel Didier, Frédéric Rieux-Laucat, Mickael M. Ménager
Gain-of-function mutations inSTING1, which encodes the Stimulator of Interferon Gene (STING), result in a severe autoinflammatory disease termed STING-associated vasculopathy with onset in infancy (SAVI). Although elevated type I interferon (IFN) pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9640bb6c4708d17332691c4f41d76708
https://doi.org/10.1101/2023.04.25.23288913
https://doi.org/10.1101/2023.04.25.23288913
