Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jean-Claude Beauvillain"'
Autor:
Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 3, Pp 686-696 (2007)
The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta). Abeta derives from the amyloid p
Externí odkaz:
https://doaj.org/article/5a0995a281d244c7b4906161afb967cd
Autor:
Alexis Bretteville, Kunie Ando, Antoine Ghestem, Anne Loyens, Séverine Bégard, Jean-Claude Beauvillain, Nicolas Sergeant, Malika Hamdane, Luc Buée
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4843 (2009)
The role of Tau phosphorylation in neurofibrillary degeneration linked to Alzheimer's disease remains to be established. While transgenic mice based on FTDP-17 Tau mutations recapitulate hallmarks of neurofibrillary degeneration, cell models could be
Externí odkaz:
https://doaj.org/article/be175fede5414d1c891f064a9fc359ad
Publikováno v:
Endocrinology. 149:587-596
The activation of nitric oxide (NO) signaling pathways in hypothalamic neurons plays a key role in the control of GnRH secretion that is central to reproductive function. It is unknown whether NO directly modulates the firing behavior of GnRH neurons
Autor:
Sophie Rogée, Morvane Colin, Jean-Claude D'Halluin, Jean-Claude Beauvillain, Claudine Bernard, Anne Loyens, E. Grellier
Publikováno v:
Molecular Therapy. 15(11):1963-1972
Most adenoviral vectors (HAdvs) elaborated for gene therapy are derived from serotype 5 viruses that use clathrin-coated vesicle endocytosis for cell entry. However, it appears that adenoviral vectors are able to take advantage of lipid raft/caveolae
Autor:
Vincent Prevot, Jean-Claude Beauvillain, Sebastien G. Bouret, Pierre Poulain, Bénédicte Dehouck, Valérie Buée-Scherrer
Publikováno v:
Psychoneuroendocrinology. 32:S46-S51
It is becoming increasingly apparent that non-neuronal cells play a critical role in generating and regulating the flow of information within the brain. Among these non-neuronal cells, astroglial cells have been shown to play important roles in the c
Autor:
Hervé Drobeck, Séverine Bégard, André Delacourte, Jean-Claude Beauvillain, Anne Loyens, Marie-Christine Galas, Nicolas Sergeant, Valérie Vingtdeux, Patrick Gelé, Malika Hamdane, Luc Buée
Publikováno v:
Journal of Biological Chemistry. 282:18197-18205
Amyloid precursor protein (APP) metabolism is central to the pathogenesis of Alzheimer disease. We showed recently that the amyloid intracellular domain (AICD), which is released by gamma-secretase cleavage of APP C-terminal fragments (CTFs), is stro
Autor:
Jean-Claude Beauvillain, Susan Tamiji, Philippe Marchetti, Martine Tual, Renata Polakowska, Pierre Formstecher, Laurent Mortier, Emmanuel Delaporte, Nathalie Jouy
Publikováno v:
Journal of Investigative Dermatology. 125(4):647-658
Terminally differentiated keratinocytes are dead enucleated squams. We showed previously that the mitochondria-dependent cell death pathway might be gradually activated as differentiation progresses. In this study, we demonstrated that protoporphyrin
Autor:
Steve Lancel, Charles Fournier, Anne Loyens, Philippe Marchetti, Jean-Claude Beauvillain, Jerome Kluza, Christian Bailly, Miguel-Angel Gallego
Publikováno v:
Oncogene. 23:7018-7030
Doxorubicin is one of the most largely prescribed antitumor drug for the treatment of breast, liver and colon cancers as well as leukemia, but the cardiotoxicity of this anthracycline derivative limits its clinical use. Although doxorubicin is toxic
Publikováno v:
Endocrinology. 145:1794-1801
In vitro studies using immortalized GT1 cells suggest that hypothalamic astrocytes employ TGFbeta(1) to directly regulate the secretion of GnRH, the neurohormone that controls sexual maturation and adult reproductive function. However, whether such a
Publikováno v:
Journal de la Société de Biologie. 198:68-72
De nombreux travaux publies ces dix dernieres annees demontrent que la secretion de GnRH est susceptible d’etre modulee par des facteurs provenant de cellules gliales mais aussi de l’endothelium des capillaires du plexus porte. Parmi les facteurs