Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jean-Christophe Wyss"'
Autor:
Lerisa Govender, Josip Mikulic, Jean-Christophe Wyss, Olivier Gaide, Margot Thome, Dela Golshayan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation v
Externí odkaz:
https://doaj.org/article/5f1f7825b196457791b4f88888f98f2f
Autor:
Jean-Christophe Wyss, Rajesh Kumar, Josip Mikulic, Manfred Schneider, Jean-Luc Mary, Johannes D. Aebi, Lucienne Juillerat-Jeanneret, Dela Golshayan
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The mitochondria-active tetrapeptide SS-31 can control oxidative tissue damage in kidney diseases. To investigate other potential beneficial nephroprotective effects of SS-31, in vivo murine models of acute tubular injury and glomerular damage were d
Externí odkaz:
https://doaj.org/article/1a7a2b4aee4a442e8eb6bb2ce63a205e
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
In recent years, regulatory T cells (Treg)-based immunotherapy has emerged as a promising strategy to promote operational tolerance after solid organ transplantation (SOT). However, a main hurdle for the therapeutic use of Treg in transplantation is
Externí odkaz:
https://doaj.org/article/8afe6b6ef47f48439aa2153170716471
Autor:
Rajesh Kumar, Anne-Catherine Clerc, Ilaria Gori, Ronan Russell, Chiara Pellegrini, Lerisa Govender, Jean-Christophe Wyss, Dela Golshayan, Geraldine O Canny
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89742 (2014)
Endometriosis, a leading cause of pelvic pain and infertility, is characterized by ectopic growth of endometrial-like tissue and affects approximately 176 million women worldwide. The pathophysiology involves inflammatory and angiogenic mediators as
Externí odkaz:
https://doaj.org/article/38800685721149aeb2a7655c6cd80daa
Autor:
Yannick D Muller, Gang Mai, Philippe Morel, Véronique Serre-Beinier, Carmen Gonelle-Gispert, Gisella Puga Yung, Driss Ehirchiou, Jean-Christophe Wyss, Sinda Bigenzahn, Magali Irla, Christoph Heusser, Déla Golshayan, Jörg D Seebach, Thomas Wekerle, Leo H Bühler
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10352 (2010)
BACKGROUND: Anti-CD154 (MR1) monoclonal antibody (mAb) and rapamycin (RAPA) treatment both improve survival of rat-to-mouse islet xenograft. The present study investigated the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft surv
Externí odkaz:
https://doaj.org/article/7b2f6edb0d8748e6bd2e5084c660d39a
Autor:
Jean-Christophe Wyss, Margot Thome, Josip Mikulic, Dela Golshayan, Olivier Gaide, Lerisa Govender
Publikováno v:
Frontiers in immunology, vol. 11, pp. 576651
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b797a8a8193799ab9e7e867e1f04a1bd
https://serval.unil.ch/notice/serval:BIB_67419B803F44
https://serval.unil.ch/notice/serval:BIB_67419B803F44
Autor:
Lucienne Juillerat-Jeanneret, Manfred Schneider, Rajesh Kumar, Dela Golshayan, Johannes Aebi, Josip Mikulic, Jean-Christophe Wyss
Publikováno v:
American journal of physiology. Renal physiology, vol. 314, no. 5, pp. F736-F746
The Notch pathway has been reported to control tissue damage in acute kidney diseases. To investigate potential beneficial nephroprotective effects of targeting Notch, we developed chemically functionalized γ-secretase inhibitors (GSIs) targeting γ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77868485b9baf04d77db071d0187f6fc
https://serval.unil.ch/notice/serval:BIB_C1BB88B05E11
https://serval.unil.ch/notice/serval:BIB_C1BB88B05E11
Autor:
Hans-Anton Lehr, Caroline Wyss Abulker, Dela Golshayan, Jean-Christophe Wyss, Robert I. Lechler, Stephan C. Schaefer, Manuel Pascual
Publikováno v:
International Immunopharmacology. 9:683-688
The mechanisms by which CD4(+)CD25(+)Foxp3(+) T (Treg) cells regulate effector T cells in a transplantation setting and their in vivo homeostasis still remain to be clarified. Using a mouse adoptive transfer model, we analyzed the in vivo expansion,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ddf1b6e59367833ea0a697d13cb7db
https://doi.org/10.1016/j.intimp.2008.12.006
https://doi.org/10.1016/j.intimp.2008.12.006
Autor:
Alexander Flohr, Lucienne Juillerat-Jeanneret, Isabelle Walter, Jean-Christophe Wyss, Rajesh Kumar, Manfred Schneider, Johannes Aebi, Dela Golshayan
Publikováno v:
Journal of medicinal chemistry. 58(20)
Notch is a membrane inserted protein activated by the membrane-inserted γ-secretase proteolytic complex. The Notch pathway is a potential therapeutic target for the treatment of renal diseases but also controls the function of other cells, requiring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d146e4b26b9fd3b8aede007caf4e46
https://pubmed.ncbi.nlm.nih.gov/26421850
https://pubmed.ncbi.nlm.nih.gov/26421850
Publikováno v:
Molecular and Cellular Biology, Vol. 22, No 23 (2002) pp. 8241-53
Yra1p/REF participates in mRNA export by recruiting the export receptor Mex67p to messenger ribonucleoprotein (mRNP) complexes. Yra1p also binds Sub2p, a DEAD box ATPase/RNA helicase implicated in splicing and required for mRNA export. We identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c29315020203be5c3324173355d585
https://doi.org/10.1128/mcb.22.23.8241-8253.2002
https://doi.org/10.1128/mcb.22.23.8241-8253.2002