Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Jean-Christophe Rochet"'
Autor:
Shichen Wu, Junkai Xie, Han Zhao, Xihui Zhao, Oscar F. Sánchez, Jean-Christophe Rochet, Jennifer L. Freeman, Chongli Yuan
Publikováno v:
Environment International, Vol 190, Iss , Pp 108914- (2024)
PFOA is a legacy Per- and Polyfluorinated Substances (PFAS), a group of chemicals widely used in various industrial applications and consumer products. Although there has been a voluntary phase out of PFOA since 2005, it is still widely detected in v
Externí odkaz:
https://doaj.org/article/ff9ac210c41c4b7eb98c04a8a23fd177
Autor:
Bartek Rajwa, Md Mobasshir Arshed Naved, Mohammad Adibuzzaman, Ananth Y. Grama, Babar A. Khan, M. Murat Dundar, Jean-Christophe Rochet
Publikováno v:
PLOS Digital Health, Vol 3, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/9c4e50a59e5b4ad49bdbb6050a2a5c15
Autor:
Eduardo Ramirez, Sehong Min, Susantha K. Ganegamage, Kazuma Shimanaka, Magaly Guzman Sosa, Ulf Dettmer, Jean-Christophe Rochet, Jessica S. Fortin
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100938- (2023)
Alzheimer’s disease (AD) is a multifactorial, chronic neurodegenerative disease characterized by the presence of extracellular β-amyloid (Aβ) plaques, intraneuronal neurofibrillary tangles (NFTs), activated microglial cells, and an inflammatory s
Externí odkaz:
https://doaj.org/article/d6777e6966384829a372fdced7a39554
Publikováno v:
Biology, Vol 12, Iss 9, p 1169 (2023)
A hallmark of aging and neurodegenerative diseases is a disruption of proteome homeostasis (“proteostasis”) that is caused to a considerable extent by a decrease in the efficiency of protein degradation systems. The ubiquitin proteasome system (U
Externí odkaz:
https://doaj.org/article/fbd2e9bf0bbb46d282957a421a7d4433
Autor:
Mitali A. Tambe, Aurélie de Rus Jacquet, Katherine E. Strathearn, Jennifer A. Hensel, Bryce D. Colón, Aswathy Chandran, Gad G. Yousef, Mary H. Grace, Mario G. Ferruzzi, Qingli Wu, James E. Simon, Mary Ann Lila, Jean-Christophe Rochet
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1463 (2023)
Parkinson’s disease (PD) is a neurodegenerative disorder involving motor symptoms caused by a loss of dopaminergic neurons in the substantia nigra region of the brain. Epidemiological evidence suggests that anthocyanin (ANC) intake is associated wi
Externí odkaz:
https://doaj.org/article/aad750b8ac9848b184a5335053c1f614
Autor:
Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L. Oblak, Cristian A. Lasagna-Reeves
Publikováno v:
Cells, Vol 12, Iss 12, p 1597 (2023)
The role of TREM2 in Alzheimer’s disease (AD) is not fully understood. Previous studies investigating the effect of TREM2 deletion on tauopathy mouse models without the contribution of b-amyloid have focused only on tau overexpression models. Herei
Externí odkaz:
https://doaj.org/article/f8243020efa242c8bd809996117876e2
Autor:
Natalie Landeck, Katherine E. Strathearn, Daniel Ysselstein, Kerstin Buck, Sayan Dutta, Siddhartha Banerjee, Zhengjian Lv, John D. Hulleman, Jagadish Hindupur, Li-Kai Lin, Sonal Padalkar, Lia A. Stanciu, Yuri L. Lyubchenko, Deniz Kirik, Jean-Christophe Rochet
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Abstract Background α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics th
Externí odkaz:
https://doaj.org/article/577ae13724214a3bac084228b03fe4b4
Publikováno v:
Bio-Protocol, Vol 10, Iss 18 (2020)
One of the major histopathological hallmarks of Parkinson’s disease are Lewy bodies (LBs) –cytoplasmic inclusions, enriched with fibrillar forms of the presynaptic protein alpha-synuclein (α-syn). Progressive deposition of α-syn into LBs is ena
Externí odkaz:
https://doaj.org/article/fcf2162d6b3b4b719e221db0bf713bf6
Autor:
Katalin Solti, Wei-Li Kuan, Balázs Fórizs, Gergely Kustos, Judith Mihály, Zoltán Varga, Balázs Herberth, Éva Moravcsik, Róbert Kiss, Manuela Kárpáti, Anna Mikes, Yanyan Zhao, Tímea Imre, Jean-Christophe Rochet, Franklin Aigbirhio, Caroline H. Williams-Gray, Roger A. Barker, Gergely Tóth
Publikováno v:
Neurobiology of Disease, Vol 142, Iss , Pp 104971- (2020)
Externí odkaz:
https://doaj.org/article/cf8c2877f3424441a63e97e4ed53e2dd
Publikováno v:
Bio-Protocol, Vol 10, Iss 14 (2020)
Lipid membranes are involved in regulating biochemical and biological processes and in modulating the selective permeability of cells, organelles, and vesicles. Membrane composition, charge, curvature, and fluidity all have concerted effects on cellu
Externí odkaz:
https://doaj.org/article/0955fe56fb0e4b97bfd9d0344fe8f7db