Výsledky vyhledávání - "Jean-Christophe Rain"

Akademický článek

Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs

Autor: Francesca Filippini, Sébastien Nola, Ahmed Zahraoui, Kevin Roger, Mansoore Esmaili, Ji Sun, José Wojnacki, Anaïs Vlieghe, Philippe Bun, Stéphanie Blanchon, Jean-Christophe Rain, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Chiara Guerrera, Thierry Galli

Publikováno v: Cell Reports, Vol 42, Iss 3, Pp 112221- (2023)

Summary: The neuropeptide VGF was recently proposed as a neurodegeneration biomarker. The Parkinson’s disease-related protein leucine-rich repeat kinase 2 (LRRK2) regulates endolysosomal dynamics, a process that involves SNARE-mediated membrane fus

Externí odkaz: https://doaj.org/article/c86cc19d59e746bf9eff4fe608506af2

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Akademický článek

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

Autor: Mark Donovan, Mélanie Salamito, Agnès Thomas-Collignon, Lucie Simonetti, Stephanie Desbouis, Jean-Christophe Rain, Etienne Formstecher, Dominique Bernard

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232679 (2020)

Skin aspartic acid protease (SASPase) is believed to be a key enzyme involved in filaggrin processing during epidermal terminal differentiation. Since little is known about the regulation of SASPase function, the aim of this study was to identify inv

Externí odkaz: https://doaj.org/article/4f6c3a9128d24d7480873489be931749

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Akademický článek

The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

R2TP is an HSP90 co-chaperone composed of an RPAP3-PIH1D1 heterodimer, which binds two essential AAA+ ATPases RUVBL1/RUVBL2. Here authors use a structural approach to study RPAP3 and find an RPAP3-like protein (SPAG1) which also forms a co-chaperone

Externí odkaz: https://doaj.org/article/f9bce095aa2a4c49a49a7a66e4c6ecf6

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Akademický článek

NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies

Autor: Sandrine Moutel, Nicolas Bery, Virginie Bernard, Laura Keller, Emilie Lemesre, Ario de Marco, Laetitia Ligat, Jean-Christophe Rain, Gilles Favre, Aurélien Olichon, Franck Perez

Publikováno v: eLife, Vol 5 (2016)

In vitro selection of antibodies allows to obtain highly functional binders, rapidly and at lower cost. Here, we describe the first fully synthetic phage display library of humanized llama single domain antibody (NaLi-H1: Nanobody Library Humanized 1

Externí odkaz: https://doaj.org/article/14f35b25914d4395a83a9126716bf545

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Akademický článek

HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.

Autor: Claire Maudet, Adèle Sourisce, Loïc Dragin, Hichem Lahouassa, Jean-Christophe Rain, Serge Bouaziz, Bertha Cécilia Ramirez, Florence Margottin-Goguet

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77320 (2013)

The Vpr protein from type 1 and type 2 Human Immunodeficiency Viruses (HIV-1 and HIV-2) is thought to inactivate several host proteins through the hijacking of the DCAF1 adaptor of the Cul4A ubiquitin ligase. Here, we identified two transcriptional r

Externí odkaz: https://doaj.org/article/a1bf6b764bdc48eaaa80f76809438c1e

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