Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jean-Christophe Poncer"'
Autor:
Céline Jaillard, Farah Ouechtati, Emmanuelle Clérin, Géraldine Millet-Puel, Mariangela Corsi, Najate Aït-Ali, Frédéric Blond, Quentin Chevy, Lara Gales, Mélissa Farinelli, Deniz Dalkara, José-Alain Sahel, Jean-Charles Portais, Jean-Christophe Poncer, Thierry Léveillard
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102198- (2021)
The nucleoredoxin gene NXNL2 encodes for two products through alternative splicing, rod-derived cone viability factor-2 (RdCVF2) that mediates neuronal survival and the thioredoxin-related protein (RdCVF2L), an enzyme that regulates the phosphorylati
Externí odkaz:
https://doaj.org/article/ad3fc9da614f44d681064fa163f7b7dd
Autor:
Albert Giralt, Veronica Brito, Quentin Chevy, Clémence Simonnet, Yo Otsu, Carmen Cifuentes-Díaz, Benoit de Pins, Renata Coura, Jordi Alberch, Sílvia Ginés, Jean-Christophe Poncer, Jean-Antoine Girault
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Several kinases regulate spine morphology and plasticity. Here, the authors show that the tyrosine kinase Pyk2 regulates hippocampal plasticity and contributes to cognitive and hippocampal plasticity deficits in a mouse model of Huntington’s diseas
Externí odkaz:
https://doaj.org/article/37e17f6f0f9040dab7fdc72ee507d46c
Autor:
Anne Roumier, Olivier Pascual, Catherine Béchade, Shirley Wakselman, Jean-Christophe Poncer, Eleonore Réal, Antoine Triller, Alain Bessis
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2595 (2008)
BackgroundEpidemiological studies have linked maternal infection during pregnancy to later development of neuropsychiatric disorders in the offspring. In mice, experimental inflammation during embryonic development impairs behavioral and cognitive pe
Externí odkaz:
https://doaj.org/article/94994fbe8816427c814024dac0fcffad
Autor:
Marie Goutierre, Sana Al Awabdh, Florian Donneger, Emeline François, Daniel Gomez-Dominguez, Theano Irinopoulou, Liset Menendez de la Prida, Jean Christophe Poncer
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 91-103.e7 (2019)
Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders. Paradoxical, excitatory GABA signaling is usually
Externí odkaz:
https://doaj.org/article/e639bdd041d9453db79f8a9062f7a422
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic responses mediated by GlyR and GABAAR display a hyperpolarizing shift
Externí odkaz:
https://doaj.org/article/200a1305cdbd43f5b600b9afdfe8ec29
Autor:
Sabine Lévi, Marion Russeau, Oana Vigy, Martial Séveno, Philippe Marin, Florian Donneger, Pauline Weinzettl, Sana Al Awabdh, Marie Goutierre, Imane Moutkine, Jean Christophe Poncer
Publikováno v:
J Neurosci
The K+-Cl–cotransporter KCC2, encoded by theSlc12a5gene, is a neuron-specific chloride extruder that tunes the strength and polarity of GABAAreceptor-mediated transmission. In addition to its canonical ion transport function, KCC2 also regulates sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183186931c5b509484e6a5d96f8e5ac7
https://doi.org/10.1523/jneurosci.2926-20.2021
https://doi.org/10.1523/jneurosci.2926-20.2021
Autor:
Clémence Simonnet, Manisha Sinha, Marie Goutierre, Imane Moutkine, Stéphanie Daumas, Jean Christophe Poncer
Publikováno v:
Neuropsychopharmacology
Neuropsychopharmacology, 2022, Online ahead of print. ⟨10.1038/s41386-022-01480-5⟩
Neuropsychopharmacology, 2022, Online ahead of print. ⟨10.1038/s41386-022-01480-5⟩
Delayed upregulation of the neuronal chloride extruder KCC2 underlies the progressive shift in GABA signaling polarity during development. Conversely, KCC2 downregulation is observed in a variety of neurological and psychiatric disorders often associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e973dfc6e3d865d825dd192329de5591
https://pubmed.ncbi.nlm.nih.gov/36302847
https://pubmed.ncbi.nlm.nih.gov/36302847
Publikováno v:
The Journal of Physiology
The Journal of Physiology, 2020, Epub ahead of print. ⟨10.1113/JP279221⟩
The Journal of Physiology, 2020, Epub ahead of print. ⟨10.1113/JP279221⟩
Key points Cation-chloride cotransporters (CCCs) play a critical role in controlling the efficacy and polarity of GABAA receptor (GABAA R)-mediated transmission in the brain, yet their expression and function in GABAergic interneurons has been overlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335f4191cdd5798c5f7305cf0f00f6b6
https://doi.org/10.1113/jp279221
https://doi.org/10.1113/jp279221
Autor:
Emmanuelle Clérin, Frédéric Blond, Mariangela Corsi, Farah Ouechtati, Jean-Charles Portais, Géraldine Millet-Puel, Thierry Léveillard, Mélissa Farinelli, Lara Gales, Deniz Dalkara, Céline Jaillard, Jean Christophe Poncer, José-Alain Sahel, Najate Aït-Ali, Quentin Chevy
Publikováno v:
Redox Biology, Vol 48, Iss, Pp 102198-(2021)
Redox Biology
Redox Biology, Elsevier, 2021, 48, pp.102198. ⟨10.1016/j.redox.2021.102198⟩
Redox Biology, 2021, 48, pp.102198. ⟨10.1016/j.redox.2021.102198⟩
Redox Biology
Redox Biology, Elsevier, 2021, 48, pp.102198. ⟨10.1016/j.redox.2021.102198⟩
Redox Biology, 2021, 48, pp.102198. ⟨10.1016/j.redox.2021.102198⟩
International audience; The nucleoredoxin gene NXNL2 encodes for two products through alternative splicing, rod-derived cone viability factor-2 (RdCVF2) that mediates neuronal survival and the thioredoxin-related protein (RdCVF2L), an enzyme that reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8affb455f241b6ed1fe8da52100f37
http://www.sciencedirect.com/science/article/pii/S221323172100358X
http://www.sciencedirect.com/science/article/pii/S221323172100358X
Autor:
Valerio Frazzini, Bertrand Mathon, Florian Donneger, Louis Cousyn, Aurélie Hanin, V.-H. Nguyen-Michel, Claude Adam, Virginie Lambrecq, Sophie Dupont, Jean Christophe Poncer, Franck Bielle, Vincent Navarro
Publikováno v:
Journal of neurology. 269(8)
Focal neuronal lipofuscinosis (FNL) is an uncommon epileptic disorder related to an excess of lipofuscin accumulation within dysmorphic-appearing neurons (DANs), whose epileptogenic mechanisms are still poorly understood. It shares some clinical and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f0072c5c4620eb5ba2e1d471598233
https://pubmed.ncbi.nlm.nih.gov/35254479
https://pubmed.ncbi.nlm.nih.gov/35254479