Myths and Methodologies: Understanding the health impact of head down bedrest for the benefit of older adults and astronauts. Study protocol of the Canadian Bedrest Study

Autor: Guy Hajj‐Boutros, Vita Sonjak, Andréa Faust, Sharmila Balram, Jean‐Christophe Lagacé, Philippe St‐Martin, Donya Naz Divsalar, Farshid Sadeghian, Teresa Liu‐Ambrose, Andrew P. Blaber, Isabelle J. Dionne, Simon Duchesne, Saija Kontulainen, Olga Theou, José A. Morais

Publikováno v: Experimental Physiology, Vol 109, Iss 5, Pp 812-827 (2024)

Abstract Weightlessness during spaceflight can harm various bodily systems, including bone density, muscle mass, strength and cognitive functions. Exercise appears to somewhat counteract these effects. A terrestrial model for this is head‐down bedr

Externí odkaz: https://doaj.org/article/a76672bb697a4fbeab6cbe158396de28

A counterintuitive perspective for the role of fat‐free mass in metabolic health

Autor: Jean‐Christophe Lagacé, Martin Brochu, Isabelle J. Dionne

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 2, Pp 343-347 (2020)

Abstract Fat‐free mass (FFM) has long been recognized to play a role in metabolic homeostasis. Over the years, it has become widely accepted by the scientific and general community alike that having a greater FFM can be protective for metabolic hea

Externí odkaz: https://doaj.org/article/fe1fc0e92066408aad256de7050faba2

Exercising for Insulin Sensitivity – Is There a Mechanistic Relationship With Quantitative Changes in Skeletal Muscle Mass?

Autor: Jasmine Paquin, Jean-Christophe Lagacé, Martin Brochu, Isabelle J. Dionne

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Skeletal muscle (SM) tissue has been repetitively shown to play a major role in whole-body glucose homeostasis and overall metabolic health. Hence, SM hypertrophy through resistance training (RT) has been suggested to be favorable to glucose homeosta

Externí odkaz: https://doaj.org/article/ae10995135fa44b084d2c7e1e60e12f0

A counterintuitive perspective for the role of fat‐free mass in metabolic health

Autor: Isabelle J. Dionne, Martin Brochu, Jean-Christophe Lagacé

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 2, Pp 343-347 (2020)
Journal of Cachexia, Sarcopenia and Muscle

Fat‐free mass (FFM) has long been recognized to play a role in metabolic homeostasis. Over the years, it has become widely accepted by the scientific and general community alike that having a greater FFM can be protective for metabolic health. Henc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73e84a8bc1ccbf4547a0203d95723fa
https://doi.org/10.1002/jcsm.12520

Grape polyphenols and exercise training have distinct molecular effects on cardiac hypertrophy in a model of obese insulin-resistant rats

Autor: M. Hokayem, Bernard Jover, Mamta Dass, Marie Demion, Catherine Bisbal, Karen Lambert, Anne Virsolvy, Jean-Christophe Lagacé, Annick Bourret

Publikováno v: Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry, 2020, pp.108522. ⟨10.1016/j.jnutbio.2020.108522⟩
Journal of Nutritional Biochemistry, Elsevier, 2020, pp.108522. ⟨10.1016/j.jnutbio.2020.108522⟩

Obesity and exercise lead to structural changes in heart such as cardiac hypertrophy. The underlying signaling pathways vary according to the source of the overload, be it physiological (exercise) or pathologic (obesity). The physiological pathway re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb3af276cdb3376086802c2a73edc48
https://hal.science/hal-02965325/document