Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jean-Christophe Gauvin"'
Autor:
Peter Seiler, L. Jacob, Swen Seeland, S. Diethelm, N. Tidten-Luksch, Jean-Philippe Surivet, M. Wicki, Georg Rueedi, Jean-Luc Specklin, Michel Enderlin-Paput, Christian Hubschwerlen, Azely Mirre, R. Lange, G. Mathieu, Christine Schmitt, C. Herrmann, Philippe Panchaud, A.-C. Blumstein, A. Mac Sweeney, F. Masse, Daniel Ritz, Jean-Christophe Gauvin, Carmela Gnerre
Publikováno v:
Journal of Medicinal Chemistry. 63:66-87
UDP-3-O-((R)-3-hydroxymyristoyl)-N-glucosamine deacetylase (LpxC) is as an attractive target for the discovery and development of novel antibacterial drugs to address the critical medical need created by multidrug resistant Gram-negative bacteria. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae4ad619b6cf3e0f3c6f741f71c0456
https://doi.org/10.1021/acs.jmedchem.9b01604
https://doi.org/10.1021/acs.jmedchem.9b01604
Autor:
Michel Enderlin-Paput, Swen Seeland, A.-C. Blumstein, Daniel Ritz, Peter Seiler, R. Lange, Jean-Philippe Surivet, Christine Schmitt, F. Masse, Jean-Christophe Gauvin, S. Diethelm, L. Jacob, Charlyse Herrmann, Carmela Gnerre, Hans H. Locher, G. Mathieu, Azely Mirre, Georg Rueedi, Philippe Panchaud
Publikováno v:
Journal of medicinal chemistry. 63(1)
LpxC inhibitors were optimized starting from lead compounds with limited efficacy and solubility and with the goal to provide new options for the treatment of serious infections caused by Gram-negative pathogens in hospital settings. To enable the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8724e5d5a4339ed1cc3153b7f635fcc4
https://pubmed.ncbi.nlm.nih.gov/31804829
https://pubmed.ncbi.nlm.nih.gov/31804829
Autor:
Thierry Bruyère, Eric A. Ertel, Stephanie Enderlin-Paput, Hans H. Locher, Michel Enderlin-Paput, Daniel Ritz, Christopher Kohl, Jean-Christophe Gauvin, Patrick Hess, Jean-Philippe Surivet, Azely Mirre, Daniel Bur, Cornelia Zumbrunn, Georg Rueedi, Christian Hubschwerlen, Peter Seiler
Publikováno v:
Journal of Medicinal Chemistry. 60:3776-3794
There is an urgent unmet medical need for novel antibiotics that are effective against a broad range of bacterial species, especially multidrug resistant ones. Tetrahydropyran-based inhibitors of bacterial type II topoisomerases (DNA gyrase and topoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03730300d43232dbf6451dab25886d78
https://doi.org/10.1021/acs.jmedchem.6b01831
https://doi.org/10.1021/acs.jmedchem.6b01831
Autor:
Daniel Bur, Azely Mirre, Michel Enderlin-Paput, Georg Rueedi, Christian Hubschwerlen, Hans H. Locher, Daniel Ritz, Cornelia Zumbrunn, Wolfgang Keck, Maria Boehme, Marina Dos Santos, Jean-Christophe Gauvin, Peter Seiler, Jean-Philippe Surivet, Verena Kaegi, Jonathan Delers, Christopher Kohl, Thierry Bruyère, Mika Gaertner
Publikováno v:
Journal of Medicinal Chemistry. 56:7396-7415
There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed8ae2c35d8e3bcbd6ebfe5d79033c9
https://doi.org/10.1021/jm400963y
https://doi.org/10.1021/jm400963y
Autor:
Marina Dos Santos, Daniel Ritz, Verena Kaegi, Azely Mirre, Maria Weiss, Stéphanie Kraemer, Daniel Bur, Michel Enderlin-Paput, Jean-Christophe Gauvin, Hakim Hadana, Georg Rueedi, Thierry Bruyère, Christian Hubschwerlen, Peter Seiler, Mika Gaertner, Jonathan Delers, Christopher Kohl, Wolfgang Keck, Jean-Philippe Surivet, Hans H. Locher, Patrick Hess, Eric A. Ertel, Cornelia Zumbrunn, Romain Sube
Publikováno v:
Journal of medicinal chemistry. 58(2)
Novel antibacterial drugs that are effective against infections caused by multidrug resistant pathogens are urgently needed. In a previous report, we have shown that tetrahydropyran-based inhibitors of bacterial type II topoisomerases (DNA gyrase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e943cd2f129c2bf098a7a5867bb79e41
https://pubmed.ncbi.nlm.nih.gov/25494934
https://pubmed.ncbi.nlm.nih.gov/25494934
Publikováno v:
Synlett. :0063-0066
A new efficient variation of the Gewald reaction is described. A number of tetrasubstituted 2-acyl aminothiophenes have been prepared via a one-pot microwave assisted Gewald reaction on solid support. This reaction proceeds in good yields within only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1a7708e2ede8e51c3ec6fb1ef4fb433
https://doi.org/10.1055/s-2003-36229
https://doi.org/10.1055/s-2003-36229