Advancing drug safety and mitigating health concerns: High-resolution mass spectrometry in the levothyroxine case study

Autor: Hana Chmelařová, Maria Carmen Catapano, Jean-Christophe Garrigues, František Švec, Lucie Nováková

Publikováno v: Journal of Pharmaceutical Analysis, Vol 14, Iss 9, Pp 100970- (2024)

Levothyroxine is a drug with a narrow therapeutic index. Changing the drug formulation composition or switching between pharmaceutical brands can alter the bioavailability, which can result in major health problems. However, the increased adverse dru

Externí odkaz: https://doaj.org/article/7847bf12144d42f69d361b0e34092d88

Evaluation of 4 quantification methods for monitoring 16 antibiotics and 1 beta-lactamase inhibitor in human serum by high-performance liquid chromatography with tandem mass spectrometry detection

Autor: Patrick, Seraissol, Thomas, Lanot, Sarah, Baklouti, Camille, Mané, Stéphanie, Ruiz, Michel, Lavit, Pascale, De Riols, Jean-Christophe, Garrigues, Peggy, Gandia

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, 2022, 219, pp.114900. ⟨10.1016/j.jpba.2022.114900⟩

Antibiotic (ATB) prescription in an intensive care unit (ICU) requires continuous monitoring of serum dosages due to the patient's pathophysiological condition. Dosing adjustment is necessary to achieve effective targeted concentrations. Since ICUs r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b73b95363fc525b851cb3af1655e3e6
https://hal.science/hal-03814985

Current trends and advances in analytical techniques for the characterization and quantification of biologically recalcitrant organic species in sludge and wastewater: A review

Autor: Jean-Christophe Garrigues, Sylvain Faixo, Véronique Gilard, Sofiane Mazeghrane, Nicolas Gehin, Etienne Paul, Stéphane Balayssac, Gilberte Gaval, Mathieu Haddad

Publikováno v: Analytica Chimica Acta
Analytica Chimica Acta, 2021, 1152, pp.338284. ⟨10.1016/j.aca.2021.338284⟩
Analytica Chimica Acta, Elsevier Masson, 2021, 1152, pp.338284. ⟨10.1016/j.aca.2021.338284⟩

International audience; The study of organic matter in wastewater is a major regulatory and environmental issue and requires new developments to identify non-biodegradable refractory compounds, produced mainly by thermal treatments. Recent advances l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4f1d256d2194108ba02e98003d8f32
https://hal.science/hal-03195665/file/S0003267021001100.pdf

Analysis of complex mixtures of polyglycerol fatty esters using liquid chromatography and high-resolution mass spectrometry: Retention, structural and relative composition study

Autor: Marlène Oswald, Stephanie Cassel, Marion Cournac, Muriel Blanzat, Nicolas Ritter, Jean-Christophe Garrigues

Publikováno v: Journal of Chromatography A
Journal of Chromatography A, 2020, 1616, pp.460792. ⟨10.1016/j.chroma.2019.460792⟩
Journal of Chromatography A, Elsevier, 2020, 1616, pp.460792. ⟨10.1016/j.chroma.2019.460792⟩

International audience; Polyglycerol esters (PGEs), produced by esterification of fatty acids on polyglycerols, were analysed by High Resolution Mass Spectrometry (HRMS), HPLC-MS and U-HPLC-MS. A structural study of PGEs in 4 samples synthesised by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad9c28aaada6076ecffbdd80d8893ca
https://hal.science/hal-04103687

Analysis of the retention of tetracyclines on reversed-phase columns: Chemometrics, design of experiments and quantitative structure-property relationship (QSPR) study for interpretation and optimization

Autor: Florence Benoit-Marquié, Jean Christophe Garrigues, Lafossas Claire

Publikováno v: Talanta
Talanta, 2019, 198, pp.550-559. ⟨10.1016/j.talanta.2019.02.051⟩
Talanta, Elsevier, 2019, 198, pp.550-559. ⟨10.1016/j.talanta.2019.02.051⟩

In this study, design of experiments was applied for the analysis of 6 reversed phase U-HPLC columns used for the separation of four tetracyclines (TCs): tetracycline, doxycycline, chlortetracycline and oxytetracycline in different elution conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355861031d5e9dbcad41304ec8769857
https://hal.science/hal-02194427/file/S0039914019301857.pdf