Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jean-Christophe Delpech"'
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101670- (2022)
Summary: Numerous approaches have been developed to isolate microglia from the brain, but procedures using enzymatic dissociation at 37°C can introduce drastic transcriptomic changes and confound results from gene expression assays. Here, we present
Externí odkaz:
https://doaj.org/article/adaec674aa724706a9101d53135bbef5
Autor:
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Over the last century, westernization of dietary habits has led to a dramatic reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). In particular, low maternal intake of n-3 PUFAs throughout gestation and lactation causes defect
Externí odkaz:
https://doaj.org/article/2c731041c18649f78b13f6764f064280
Autor:
Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A. Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-14 (2020)
Abstract Background Neuronal accumulation of misfolded microtubule-associated protein tau is a hallmark of neuropathology in Alzheimer’s disease, frontotemporal dementia, and other tauopathies, and has been a therapeutic target. Microglia can sprea
Externí odkaz:
https://doaj.org/article/2a1a291cc9424f7d8922c6b52239d88a
Autor:
Julie Sauvant, Jean-Christophe Delpech, Karine Palin, Nadia De Mota, Jennifer Dudit, Agnès Aubert, Hélène Orcel, Pascale Roux, Sophie Layé, Françoise Moos, Catherine Llorens-Cortes, Agnès Nadjar
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87421 (2014)
Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma a
Externí odkaz:
https://doaj.org/article/9d061029a0304ac48f86863adfd67f4b
Autor:
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Abstract Background Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microgl
Externí odkaz:
https://doaj.org/article/800b4c29589f4c8daad1d601b3e96fe1
Autor:
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/04b64ae785aa4e1aa478e6025961ad00
Autor:
Diankun Yu, Tao Li, Jean-Christophe Delpech, Beika Zhu, Priya Kishore, Tatsuhiro Koshi, Rong Luo, Karishma J.B. Pratt, Galina Popova, Tomasz J. Nowakowski, Saul A. Villeda, Xianhua Piao
Publikováno v:
Science Advances. 8
Parvalbumin-positive (PV + ) interneurons play a critical role in maintaining circuit rhythm in the brain, and their reduction is implicated in autism spectrum disorders. Animal studies demonstrate that maternal immune activation (MIA) leads to reduc
Autor:
Merina Varghese, Patrick R. Hof, Emma Catherine Hays, Srinidhi Venkatesan Kalavai, Jennifer I. Luebke, Dhruba Pathak, Seiko Ikezu, W. Evan Johnson, Maria Medalla, Tsuneya Ikezu, Jean-Christophe Delpech
Publikováno v:
Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (611), ⟨10.1126/scitranslmed.abe8455⟩
Science translational medicine
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (611), ⟨10.1126/scitranslmed.abe8455⟩
Science translational medicine
Abnormally phosphorylated tau, an early neuropathologic marker of Alzheimer’s disease (AD), first occurs in the brain’s entorhinal cortex layer II (ECII) and then spreads to the CA1 field of the hippocampus. Animal models of tau propagation aimin
Autor:
Sol Beccari, Charlotte Madore, Amanda Sierra, Oleg Butovsky, Stéphane Grégoire, Pierre Gressens, Kanchan Bisht, V. De Smedt-Peyrusse, K.E. Hopperton, Lawrence Fourgeaud, Sophie Layé, Corinne Joffre, Richard P. Bazinet, Agnès Nadjar, Lionel Morel, C. Lacabanne, J. Bourel, A. Sere, Jean-Christophe Delpech, Lionel Bretillon, Andrew D. Greenhalgh, Aurore Thomazeau, Clémentine Bosch-Bouju, Agnès Aubert, Quentin Leyrolle, N. J. Grant, Cynthia Lecours, Marie-Ève Tremblay, J. Badaut
SUMMARYOmega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0975e7b0d0981d18c7e5557fdfd0d8c9
https://hal.archives-ouvertes.fr/hal-03339536/file/NutriNeuro_2019_Madore.pdf
https://hal.archives-ouvertes.fr/hal-03339536/file/NutriNeuro_2019_Madore.pdf
Autor:
Maria Ericsson, Seiko Ikezu, Naotoshi Iwahara, Jean-Christophe Delpech, Takaomi C. Saido, Shawn Herron, Kevin A. Clayton, Tsuneya Ikezu, Takashi Saito
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, BioMed Central, 2021, 16, pp.18. ⟨10.1186/s13024-021-00440-9⟩
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Molecular Neurodegeneration, BioMed Central, 2021, 16, pp.18. ⟨10.1186/s13024-021-00440-9⟩
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Background Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microglia (MGnD)