Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jean-Christophe Copin"'
Publikováno v:
eNeuro
Increasing evidence suggests that crosstalk between α-synuclein pathology formation and mitochondrial dysfunctions plays a central role in the pathogenesis of Parkinson’s disease and related synucleinopathies. While mitochondrial dysfunction is a
Autor:
Marie-Isabelle Guillot de Suduiraut, Carmen Sandi, Johannes Burtscher, Senthil K. Thangaraj, Anass Chiki, João M. F. Rodrigues, Jean-Christophe Copin, Hilal A. Lashuel
Chronic stress and associated heightened glucocorticoid levels are risk factors for depression, a common non-motor symptom in Parkinson’s disease (PD). However, how heightened glucocorticoids influence PD neuropathology [alpha-synuclein (α-Syn) co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cab958c988db72dc666732c1e69cd3d
https://doi.org/10.1101/469999
https://doi.org/10.1101/469999
Introduction: Bacterial meningitis is associated with a high mortality and a high incidence of neurological sequelae. Parainfectious vasculitis leading to ischemic brain damage is a known complication of bacterial meningitis but its treatment is unce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a78ad50ebdc49e537cfad8666fc786c
http://doc.rero.ch/record/320518/files/12028_2007_Article_43237.pdf
http://doc.rero.ch/record/320518/files/12028_2007_Article_43237.pdf
Autor:
Karl Lothard Schaller, Graham Coutts, François Mach, Sébastien Lenglet, Adam Denes, Emmanuel Pinteaux, Fabrizio Montecucco, Jean-Christophe Copin, Yvan Gasche
Publikováno v:
Journal of Cerebral Blood Flow and Metabolism, Vol. 34, No 5 (2014) pp. 802-812
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cer
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cer
The effect of recombinant human tissue plasminogen activator (rtPA) on neuroinflammation after stroke remains largely unknown. Here, we tested the effect of rtPA on expression of cellular adhesion molecules, chemokines, and cytokines, and compared th
Autor:
Fabrizio Montecucco, Sébastien Lenglet, François Mach, Jean-Christophe Copin, Yvan Gasche, Karl Lothard Schaller
Publikováno v:
Thrombosis and haemostasis
Thrombosis and Haemostasis, Vol. 112, No 2 (2014) pp. 363-378
Thrombosis and Haemostasis, Vol. 112, No 2 (2014) pp. 363-378
SummaryMatrix metalloproteinases (MMPs) are a family of more than twenty secreted and cell-surface endopeptidases. Among them, MMP2, MMP3 and MMP9 are involved in blood-brain barrier injury and neuronal death after cerebral ischaemia. On the other ha
Autor:
Graziano Pelli, Yvan Gasche, Maud Deruaz, Vincent Braunersreuther, Sébastien Lenglet, Amanda E. I. Proudfoot, Rafaela F. da Silva, Fabrizio Montecucco, Jean-Christophe Copin, Silvia Quintao, Nikolaos Stergiopulos, Luciano S. A. Capettini, Robson A.S. Santos, Fabienne Burger, Rodrigo A. Fraga-Silva, Karl Lothard Schaller, Franco Dallegri, Katia Galan, François Mach
Publikováno v:
Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow & Metabolism; Vol 33
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cer
Journal of Cerebral Blood Flow & Metabolism
Journal of Cerebral Blood Flow and Metabolism, Vol. 33, No 4 (2013) pp. 490-498
Journal of Cerebral Blood Flow & Metabolism; Vol 33
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cer
Journal of Cerebral Blood Flow & Metabolism
Journal of Cerebral Blood Flow and Metabolism, Vol. 33, No 4 (2013) pp. 490-498
Neutrophilic inflammation might have a pathophysiological role in both carotid plaque rupture and ischemic stroke injury. Here we investigated the potential benefits of the CXC chemokine binding protein Evasin 3 which potently inhibits chemokine bioa
Autor:
Asita Sarrafzadeh, Karl Lothard Schaller, Peter Vajkoczy, Philippe Bijlenga, Natacha Turck, Yvan Gasche, Daniel Jiménez Bengualid, Jean-Christophe Copin
Publikováno v:
Neurological Research, Vol. 34, No 5 (2012) pp. 455-461
The pathogenesis of delayed cerebral ischemia (DCI) in aneurysmal subarachnoid hemorrhage (aSAH) is multi-factorial and not completely elucidated. Matrix metalloproteinase-9 (MMP-9) might participate in wall remodeling leading to luminal narrowing. T
Autor:
Karl Lothard Schaller, Rafaela F. da Silva, Odysseas Kargiotis, Daniel Jiménez Bengualid, Yvan Gasche, Jean-Christophe Copin
Publikováno v:
European Journal of Neuroscience. 34:1085-1092
The role of the inducible matrix metalloproteinase (MMP)-9 in blood-brain barrier (BBB) disruption after ischemic stroke is well accepted. Recombinant tissue plasminogen activator (r-tPA) is the only approved thrombolytic treatment of ischemic stroke
Autor:
M. Bancila, Philippe Bijlenga, Yvan Gasche, Jean-Christophe Copin, Youssef Daali, Bawarjan Schatlo
Publikováno v:
Fundamental & Clinical Pharmacology. 25:469-478
Recent in vitro evidence suggests that T-type Ca(2+) channels are implicated in the mechanisms of ischemia-induced delayed neuronal cell death. The aim of this work was to study the neuroprotective potential of mibefradil and pimozide, both T-type Ca
Autor:
Jean-Christophe Copin, Martin R. Tramèr, Christopher Lysakowski, Benoit John Jenny, Christoph Czarnetzki, Laszlo Vutskits
Publikováno v:
Neurochemical Research, Vol. 33, No 7 (2008) pp. 1325-31
We measured perioperative plasma concentrations of brain-derived neurotrophic factor (BDNF), a major mediator of synaptic plasticity in the central nervous system, in males, 30-65 years old, undergoing lumbar or cervical discotomy. Patients were rand