Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jean-Christophe Beltra"'
Autor:
Jingya Qiu, Bihui Xu, Darwin Ye, Diqiu Ren, Shangshang Wang, Joseph L. Benci, Yuanming Xu, Hemant Ishwaran, Jean-Christophe Beltra, E. John Wherry, Junwei Shi, Andy J. Minn
Publikováno v:
Nature Cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe2bb2059f8755a82727b849997183b1
https://doi.org/10.1038/s43018-022-00490-y
https://doi.org/10.1038/s43018-022-00490-y
Autor:
Jean-Christophe Beltra, Mohamed S. Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Makoto Kurachi, Leon Su, Lora Picton, Yuki Muroyama, Valentina Casella, Yinghui J. Huang, Josephine R. Giles, Divij Mathew, Jonathan Belman, Max Klapholz, Hélène Decaluwe, Alexander C. Huang, Shelley L. Berger, K. Christopher Garcia, E. John Wherry
Rewiring exhausted CD8 T cells (TEX) towards more functional states is a major goal of cancer immunotherapy but has proven challenging due to the epigenetic stability of TEX. Indeed, TEX are epigenetically programmed by the transcription factor Tox.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5995e1fee72562063b9277b41f2002a9
https://doi.org/10.1101/2022.10.03.509766
https://doi.org/10.1101/2022.10.03.509766
Autor:
Mohamed S. Abdel-Hakeem, Mohammed-Alkhatim Ali, Allison R. Greenplate, Sasikanth Manne, Golnaz Vahedi, Zeyu Chen, Jean-Christophe Beltra, E. John Wherry, Josephine R. Giles, Divij Mathew, Erietta Stelekati, Kito Nzingha, John L. Johnson
Publikováno v:
Nature immunology
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e943c31b36fab90f61eab255bcc3813b
https://doi.org/10.1038/s41590-021-00975-5
https://doi.org/10.1038/s41590-021-00975-5
Autor:
Erietta Stelekati, Zhangying Cai, Sasikanth Manne, Zeyu Chen, Jean-Christophe Beltra, Lance Alec Buchness, Xuebing Leng, Svetlana Ristin, Kito Nzingha, Viktoriya Ekshyyan, Christina Niavi, Mohamed S. Abdel-Hakeem, Mohammed-Alkhatim Ali, Sydney Drury, Chi Wai Lau, Zhen Gao, Yuguang Ban, Simon K. Zhou, K. Mark Ansel, Makoto Kurachi, Martha S. Jordan, Alejandro V. Villarino, Shin Foong Ngiow, E. John Wherry
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(17)
Significance CD8 T cell exhaustion is a key underlying factor limiting immunity in chronic infections and cancer. Persistent antigen exposure antagonizes formation of functional memory CD8 T cells that provide long-term protection and, instead, drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7594f692a7d4f87986d77d9cc7783705
https://pubmed.ncbi.nlm.nih.gov/35446623
https://pubmed.ncbi.nlm.nih.gov/35446623
Autor:
Emma L. Lewis, Rong Xu, Jean-Christophe Beltra, Shin Foong Ngiow, Jordana Cohen, Rahul Telange, Alexander Crane, Deirdre Sawinski, E. John Wherry, Paige M. Porrett
Publikováno v:
Journal of Experimental Medicine. 219
Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cfc773b797072223f291339b39bf31
https://doi.org/10.1084/jem.20201599
https://doi.org/10.1084/jem.20201599
Autor:
Chih-Hang Anthony Tang, Kristin C. Hicks, Sergei I. Grivennikov, Chih-Chi Andrew Hu, Dmitry I. Gabrilovich, E. John Wherry, Fernanda Pilataxi, Shino Hanabuchi, Corinne Cayatte, Gozde Kar, Kathy Mulgrew, Aimee Landry, Evgenii N. Tcyganov, Brian Dougherty, Ayumi Hashimoto, Yulia Nefedova, David A Campbell, Susana Hayes, Wei Guo, Tim Slidel, Mohammed Alkhatim A. Ali, Jean Christophe Beltra
Publikováno v:
J Clin Invest
Myeloid-derived suppressor cells (MDSCs) are major negative regulators of immune responses in cancer and chronic infections. It remains unclear if regulation of MDSC activity in different conditions is controlled by similar mechanisms. We compared MD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c800f38b2e71685ea606f48fdfda0331
https://doi.org/10.1172/jci145971
https://doi.org/10.1172/jci145971
Autor:
Kristen E. Pauken, Zhangying Cai, Bertram Bengsch, Jonathan B. Johnnidis, Shin Foong Ngiow, Dario A. A. Vignali, Michael A. Paley, Yuki Muroyama, Sasikanth Manne, Arlene H. Sharpe, Shufei Song, Christelle Harly, Jason M. Schenkel, John Attanasio, Jesse M. Platt, Zeyu Chen, Allison R. Greenplate, Avinash Bhandoola, Steven L. Reiner, F. Bradley Johnson, Mohamed S. Abdel-Hakeem, Kito Nzingha, Jean Christophe Beltra, Makoto Kurachi, Mohammed Alkhatim A. Ali, Josephine R. Giles, Vesselin T. Tomov, E. John Wherry
Publikováno v:
Science Immunology
Science Immunology, American Association for the Advancement of Science, 2021, 6, pp.eabe3702. ⟨10.1126/sciimmunol.abe3702⟩
Science Immunology, 2021, 6, pp.eabe3702. ⟨10.1126/sciimmunol.abe3702⟩
Science Immunology, American Association for the Advancement of Science, 2021, 6, pp.eabe3702. ⟨10.1126/sciimmunol.abe3702⟩
Science Immunology, 2021, 6, pp.eabe3702. ⟨10.1126/sciimmunol.abe3702⟩
International audience; The developmental origins of memory T cells remain incompletely understood. During the expansion phase of acute viral infection, we identified a distinct subset of virus-specific CD8 + T cells that possessed distinct character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff3eb247a83689a9c02fab579e84593
https://www.hal.inserm.fr/inserm-03276330/file/ArticleHarly2021.pdf
https://www.hal.inserm.fr/inserm-03276330/file/ArticleHarly2021.pdf
Autor:
Jonathan B, Johnnidis, Yuki, Muroyama, Shin Foong, Ngiow, Zeyu, Chen, Sasikanth, Manne, Zhangying, Cai, Shufei, Song, Jesse M, Platt, Jason M, Schenkel, Mohamed, Abdel-Hakeem, Jean-Christophe, Beltra, Allison R, Greenplate, Mohammed-Alkhatim A, Ali, Kito, Nzingha, Josephine R, Giles, Christelle, Harly, John, Attanasio, Kristen E, Pauken, Bertram, Bengsch, Michael A, Paley, Vesselin T, Tomov, Makoto, Kurachi, Dario A A, Vignali, Arlene H, Sharpe, Steven L, Reiner, Avinash, Bhandoola, F Bradley, Johnson, E John, Wherry
Publikováno v:
Sci Immunol
The developmental origins of memory T cells remain incompletely understood. During the expansion phase of acute viral infection, we identified a distinct subset of virus-specific CD8(+) T cells that possessed distinct characteristics including expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b21c8c4274feba6a71315632e8e4044f
https://pubmed.ncbi.nlm.nih.gov/33452106
https://pubmed.ncbi.nlm.nih.gov/33452106
Autor:
Sasikanth Manne, Golnaz Vahedi, Allison R. Greenplate, Erietta Stelekati, Josephine R. Giles, Zeyu Chen, E. John Wherry, Divij Mathew, Mohamed S. Abdel-Hakeem, Mohammed-Alkhatim Ali, Kito Nzingha, Jean-Christophe Beltra, John L. Johnson
Publikováno v:
Nature Immunology. 22:1465-1465
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87632b40973d50647f48142f1415a605
https://doi.org/10.1038/s41590-021-01057-2
https://doi.org/10.1038/s41590-021-01057-2
Autor:
Zeyu Chen, Jean Christophe Beltra, Sasikanth Manne, Golnaz Vahedi, Caiyue Xu, Amy E. Baxter, Sixiang Yu, Chi Wai Lau, Josephine R. Giles, Erietta Stelekati, John L. Johnson, Zhicheng Ji, Omar Khan, Bertram Bengsch, Jennifer E. Wu, Alexander C. Huang, Laura A. Vella, Hongkai Ji, Ramin S. Herati, Shin Foong Ngiow, E. John Wherry, Ryan P. Staupe, Laura M. McLane, Shelley L. Berger, Xiaolu Yang, Makoto Kurachi, Zhangying Cai
Publikováno v:
Immunity
TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c7cac24e871012777a7ff7d5822ccd
https://europepmc.org/articles/PMC6943829/
https://europepmc.org/articles/PMC6943829/