Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jean-Christophe Barale"'
Autor:
Mariano Martinez, Anthony Bouillon, Sébastien Brûlé, Bertrand Raynal, Ahmed Haouz, Pedro M. Alzari, Jean-Christophe Barale
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Malaria symptoms are associated with the asexual multiplication of Plasmodium falciparum within human red blood cells (RBCs) and fever peaks coincide with the egress of daughter merozoites following the rupture of the parasitophorous vacuole
Externí odkaz:
https://doaj.org/article/ba0f32637eef4326823e45be733aa725
Autor:
Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, Jerzy Michal Dziekan, Christèle Huon, Isabell Berneburg, Stefan Rahlfs, Jean-Christophe Barale, Sheldon I. Feinstein, Aron B. Fisher, Didier Ménard, Zbynek Bozdech, Rogerio Amino, Lhousseine Touqui, Chetan E. Chitnis
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110923- (2022)
Summary: The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate t
Externí odkaz:
https://doaj.org/article/19eda5da865f4a5c9cee9657e6e2cb8f
Autor:
Giacomo Bastianelli, Anthony Bouillon, Christophe Nguyen, Dung Le-Nguyen, Michael Nilges, Jean-Christophe Barale
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109269 (2014)
Malaria remains a major global health concern. The development of novel therapeutic strategies is critical to overcome the selection of multiresistant parasites. The subtilisin-like protease (SUB1) involved in the egress of daughter Plasmodium parasi
Externí odkaz:
https://doaj.org/article/f73979815b6449ae895428828d57071d
Autor:
Daria Jacob, Claude Ruffie, Myriam Dubois, Chantal Combredet, Rogerio Amino, Pauline Formaglio, Olivier Gorgette, Gérard Pehau-Arnaudet, Charline Guery, Odile Puijalon, Jean-Christophe Barale, Robert Ménard, Frédéric Tangy, Monica Sala
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86658 (2014)
Yeasts are largely used as bioreactors for vaccine production. Usually, antigens are produced in yeast then purified and mixed with adjuvants before immunization. However, the purification costs and the safety concerns recently raised by the use of n
Externí odkaz:
https://doaj.org/article/41f3d1cfd04441a7aeba3f307dee4498
Autor:
Giacomo Bastianelli, Anthony Bouillon, Christophe Nguyen, Elodie Crublet, Stéphane Pêtres, Olivier Gorgette, Dung Le-Nguyen, Jean-Christophe Barale, Michael Nilges
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21812 (2011)
BACKGROUND: Psalmopeotoxin I (PcFK1), a protein of 33 aminoacids derived from the venom of the spider Psalmopoeus Cambridgei, is able to inhibit the growth of Plasmodium falciparum malaria parasites with an IC50 in the low micromolar range. PcFK1 was
Externí odkaz:
https://doaj.org/article/9aea6e5faaf34cb19d66cc6fa0250c4a
Autor:
Mélissa Mairet-Khedim, Camille Roesch, Nimol Khim, Sreynet Srun, Anthony Bouillon, Saorin Kim, Sopheakvatey Ke, Chhayleang Kauy, Nimol Kloeung, Rotha Eam, Chanra Khean, Chanvong Kul, Sophy Chy, Rithea Leang, Pascal Ringwald, Jean-Christophe Barale, Benoit Witkowski
Publikováno v:
Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2023, 78 (2), pp.411-417. ⟨10.1093/jac/dkac403⟩
Journal of Antimicrobial Chemotherapy, 2023, 78 (2), pp.411-417. ⟨10.1093/jac/dkac403⟩
Background In early 2016, in Preah Vihear, Northern Cambodia, artesunate/mefloquine was used to cope with dihydroartemisinin/piperaquine-resistant Plasmodium falciparum parasites. Following this policy, P. falciparum strains harbouring molecular mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b2456eff46e9ada7671a825c238aa9
https://pubmed.ncbi.nlm.nih.gov/36508338
https://pubmed.ncbi.nlm.nih.gov/36508338
Autor:
Valérie Soulard, Nathalie Dereuddre-Bosquet, Cyrille Y. Botté, Roger Le Grand, Nadia Amanzougaghene, Jean-François Franetich, Amélie Vantaux, Kutub Ashraf, Christophe-Sébastien Arnold, Benoit Witkowski, Mallaury Bordessoulles, Jean-Christophe Barale, Teun Bousema, Romain Duval, Georges Snounou, Guillaume Cazals, Shahin Tajeri, Geert-Jan van Gemert, Dominique Mazier
Publikováno v:
Life Science Alliance
Life Science Alliance, 2021, 5 (3), pp.e202101237. ⟨10.26508/lsa.202101237⟩
Life Science Alliance, Life Science Alliance LLC, 2021, 5 (3), pp.e202101237. ⟨10.26508/lsa.202101237⟩
Life Science Alliance, 5, 3
Life Science Alliance, 5
Life Science Alliance, 2021, 5 (3), pp.e202101237. ⟨10.26508/lsa.202101237⟩
Life Science Alliance, Life Science Alliance LLC, 2021, 5 (3), pp.e202101237. ⟨10.26508/lsa.202101237⟩
Life Science Alliance, 5, 3
Life Science Alliance, 5
Artemisinin-based combination therapies (ACT) are the frontline treatments against malaria worldwide. Recently the use of traditional infusions fromArtemisia annua(from which artemisinin is obtained) orA. afra(lacking artemisinin) has been controvers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e2ff5be138bf2726e2b470cedfa543
https://hal.archives-ouvertes.fr/hal-03456897
https://hal.archives-ouvertes.fr/hal-03456897
Autor:
Kutub, Ashraf, Shahin, Tajeri, Christophe-Sébastien, Arnold, Nadia, Amanzougaghene, Jean-François, Franetich, Amélie, Vantaux, Valérie, Soulard, Mallaury, Bordessoulles, Guillaume, Cazals, Teun, Bousema, Geert-Jan, van Gemert, Roger, Le Grand, Nathalie, Dereuddre-Bosquet, Jean-Christophe, Barale, Benoit, Witkowski, Georges, Snounou, Romain, Duval, Cyrille Y, Botté, Dominique, Mazier
Publikováno v:
Life Science Alliance
Infusions from two Artemisia species, one containing artemisinin, the other not, equally inhibit pre-erythrocytic and erythrocytic stages of different Plasmodium species, including two relapsing species.
Artemisinin-based combination therapies (
Artemisinin-based combination therapies (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0ba6cb185719c1f434bcfb1eb7650a5
https://pubmed.ncbi.nlm.nih.gov/34857648
https://pubmed.ncbi.nlm.nih.gov/34857648
Autor:
Jean Christophe Barale, Chanra Khean, Nimol Khim, Sopheakvatey Ke, Saorin Kim, Benoit Witkowski, Nimol Kloeung, Didier Leboulleux, Pascal Ringwald, Didier Leroy, Didier Menard, Chhayleang Kauy, Rithea Leang, Rotha Eam, Flore Nardella, Alain Pellet, Melissa Mairet-Khedim
Publikováno v:
Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2019, 74 (11), pp.3240-3244. ⟨10.1093/jac/dkz340⟩
Journal of Antimicrobial Chemotherapy, 2019, 74 (11), pp.3240-3244. ⟨10.1093/jac/dkz340⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2019, 74 (11), pp.3240-3244. ⟨10.1093/jac/dkz340⟩
Journal of Antimicrobial Chemotherapy, 2019, 74 (11), pp.3240-3244. ⟨10.1093/jac/dkz340⟩
Background Cambodia is the epicentre of resistance emergence for virtually all antimalarial drugs. Selection and spread of parasites resistant to artemisinin-based combination therapy (ACT) is a major threat for malaria elimination, hence the need to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79452f4aa0339ba58daf2ec0fdb34d08
https://hal-pasteur.archives-ouvertes.fr/pasteur-02385376
https://hal-pasteur.archives-ouvertes.fr/pasteur-02385376
Autor:
Caroline Denevault-Sabourin, Philippe Jacquiet, Espérance Moine, Olivier Gorgette, Jean-Christophe Barale, Laurence Silpa, Françoise Debierre-Grockiego, Fabien Brossier, Alain Gueiffier, Isabelle Dimier-Poisson, Cécile Enguehard-Gueiffier
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2015, 89, pp.386-400. ⟨10.1016/j.ejmech.2014.10.057⟩
European Journal of Medicinal Chemistry, 2015, 89, pp.386-400. ⟨10.1016/j.ejmech.2014.10.057⟩
European Journal of Medicinal Chemistry, Elsevier, 2015, 89, pp.386-400. ⟨10.1016/j.ejmech.2014.10.057⟩
European Journal of Medicinal Chemistry, 2015, 89, pp.386-400. ⟨10.1016/j.ejmech.2014.10.057⟩
International audience; An in vitro screening of the anti-apicomplexan activity of 51 compounds, stemming from our chemical library and from chemical synthesis, was performed. As a study model, we used Toxoplasma gondii (T. gondii), expressing β-gal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed100407dfd1f3414ca9a4ec978d8ef8
https://doi.org/10.1016/j.ejmech.2014.10.057
https://doi.org/10.1016/j.ejmech.2014.10.057