Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jean-Charles Marie"'
Publikováno v:
Psychotropes. 26:175-187
L’association NORML France essaie d’introduire aupres des pouvoirs publics, des professionnels de sante et des consommateurs la notion de reduction des risques specifiques a l’usage de cannabis. Elle presente ici les outils et methodes mis en a
Autor:
Wenye Sun, Zhenmin He, Adel M. Naylor-Olsen, Deming Xu, Joseph P. Vacca, Leanne Bedard, Ashlee M. Earl, Christina Scherer, Abigail L. Manson, Maurice D. Lee, Diane M Rush, Mark E. Fitzgerald, Mingliang Zhang, Huisheng Xu, Michelle Palmer, Joshua A. Bittker, Michael Foley, Jean-Charles Marie, Jeremy R. Duvall, Giovanni Muncipinto
Publikováno v:
ACS Infectious Diseases. 3:349-359
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options current
Autor:
Marek M, Nagiec, Jeremy R, Duvall, Adam P, Skepner, Eleanor A, Howe, Jessica, Bastien, Eamon, Comer, Jean-Charles, Marie, Stephen E, Johnston, Joseph, Negri, Michelle, Eichhorn, Julien, Vantourout, Clary, Clish, Kiran, Musunuru, Michael, Foley, Jose R, Perez, Michelle A J, Palmer
Publikováno v:
MedChemComm. 9(11)
Increased expression of the Tribbles pseudokinase 1 gene (TRIB1) is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease and myocardial infarction. We
Autor:
Carol A. Mulrooney, Morgan Welzel-O’Shea, Bérénice C. Lemercier, Edward B. Holson, Landon Durak, Sarathy Kesavan, Jeremy R. Duvall, Jingqiang Wei, Florence F. Wagner, Adrien Joliton, Laura M. Panko, Maurice D. Lee, Lisa A. Marcaurelle, Lakshmi B. Akella, Haibo Liu, Emeline L. Davoine, Jason T. Lowe, Méryl Thomas, Etienne J. Donckele, Michael Foley, Byung-Chul Suh, Giovanni Muncipinto, Ann Rowley, Jean-Charles Marie, Baudouin Gerard
Publikováno v:
The Journal of Organic Chemistry. 77:7187-7211
The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of represen
Autor:
Maurice D. Lee, Bhaumik A. Pandya, Jean-Charles Marie, Haibo Liu, Baudouin Gerard, Lisa A. Marcaurelle
Publikováno v:
The Journal of Organic Chemistry. 76:1898-1901
All stereoisomers of a highly functionalized 2,3-unsaturated C-glycoside can be accessed in 10-100 g quantities from readily available starting materials and reagents in 3-7 steps. These chiral scaffolds contain three stereogenic centers along with o
Autor:
Troy D. Ryba, Maurice D. Lee, Stephen J. Haggarty, Surya A. Reis, Eamon Comer, Nathan T. Ross, Jingqiang Wei, Byung-Chul Suh, Michael Foley, Lakshmi B. Akella, Haibo Liu, Jason T. Lowe, Yan-Ling Zhang, Wen-Ning Zhao, Jeremy R. Duvall, Daniel M. Fass, Damian W. Young, Carol Mulrooney, Lisa A. Marcaurelle, Bhaumik A. Pandya, Ann Rowley, Michelle Palmer, Baudouin Gerard, Sivaraman Dandapani, Sarathy Kesavan, Jean-Charles Marie
Publikováno v:
Journal of the American Chemical Society. 132:16962-16976
An aldol-based ‘build/couple/pair’ (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build phase, a series of asymmetric syn- and anti- aldol reactions were performed to produ
Autor:
Yuan Xiong, Tohru Taniguchi, Jean-Charles Marie, Nina Berova, Geanna K. Min, Adam R. Yeager, John A. Porco, Scott E. Schaus
Publikováno v:
The Journal of Organic Chemistry. 75:4584-4590
Asymmetric scandium(III)-catalyzed rearrangement of 3-allyloxyflavones was utilized to prepare chiral, nonracemic 3,4-chromanediones in high yields and enantioselectivities. These synthetic intermediates have been further elaborated to novel heterocy
Publikováno v:
Synlett. 2002:0553-0556
This work describes the regioselective nucleophilic ring opening and the deprotonation of α,β-epoxy-γ,δ-vinyl-silanes with nitrogen, sulfur and carbon nucleophiles. In an original way, our results point out the α,β-epoxy-silane-like or vinyloxi
Autor:
Sivaraman Dandapani, Marcel Kaiser, Jeremy R. Duvall, Andrew R. Germain, Juan C. Engel, José Carlos Rodríguez Pérez, Stuart L. Schreiber, Sebastian T. Le Quement, Danielle Kellar, Benito Munoz, Giovanni Muncipinto, James H. McKerrow, Michael Foley, Jiri Gut, Jean-Charles Marie, Michelle Palmer, Leigh C. Carmody, Ivan T. Jewett, Jair L. Siqueira-Neto, Ana Rodriguez
A phenotypic high-throughput screen using ∼100,000 compounds prepared using Diversity-Oriented Synthesis yielded stereoisomeric compounds with nanomolar growth-inhibition activity against the parasite Trypanosoma cruzi, the etiological agent of Cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566271c6a656525fb1715e6147271240
https://europepmc.org/articles/PMC4027639/
https://europepmc.org/articles/PMC4027639/
Autor:
Jeremy R. Duvall, Sarathy Kesavan, Michael Foley, Byung-Chul Suh, O'shea Morgan Welzel, Jean-Charles Marie, Bérénice C. Lemercier, Bhaumik A. Pandya, Sivaraman Dandapani, Baudouin Gerard, Tiffanie Murillo, Lisa A. Marcaurelle, Mark E. Fitzgerald, Lakshmi B. Akella, Michael Dombrowski, Diane Hamann, Jason T. Lowe, Maurice D. Lee
Publikováno v:
The Journal of organic chemistry. 78(11)
A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and methyl ester for further diversification via amine capping and