Výsledky vyhledávání - "Jean-Charles Cerottini"

Akademický článek

Tumor cell recognition efficiency by T cells.

Autor: Daniel E Speiser, Jean-Charles Cerottini, Pedro Romero

Publikováno v: PLoS Medicine, Vol 2, Iss 3, p e77; author reply e95 (2005)

Externí odkaz: https://doaj.org/article/d1f89e01b37a464abf0cfb11fc9ca86d

High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals

Autor: P R Dunbar, Vincenzo Cerundolo, Daniel E. Speiser, Pedro Romero, Jean-Charles Cerottini, Katharina Fleischhauer, Ferdy Lejeune, Danila Valmori, Danielle Liénard, Mikael J. Pittet

Publikováno v: Journal of Experimental Medicine, vol. 190, no. 5, pp. 705-15
The Journal of Experimental Medicine

Using fluorescent HLA-A*0201 tetramers containing the immunodominant Melan-A/MART-1 (Melan-A) tumor-associated antigen (Ag), we previously observed that metastatic lymph nodes of melanoma patients contain high numbers of Ag-experienced Melan-A-specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34eb4ae630c7bc379ec6c696b8b211f
https://doi.org/10.1084/jem.190.5.705

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Effects of epitope modification on T cell receptor-ligand binding and antigen recognition by seven H-2Kd-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative

Autor: Benedikt M. Kessler, Paolo Bassanini, Immanuel F. Luescher, Jean-Charles Cerottini

Publikováno v: The Journal of experimental medicine, vol. 185, no. 4, pp. 629-640
The Journal of Experimental Medicine

We tested for antigen recognition and T cell receptor (TCR)–ligand binding 12 peptide derivative variants on seven H-2Kd–restricted cytotoxic T lymphocytes (CTL) clones specific for a bifunctional photoreactive derivative of the Plasmodium berghe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20295e7d7f4529a2646d822856587215
https://doi.org/10.1084/jem.185.4.629

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Heterogeneity of inhibition of cytolytic T lymphocyte clones by monoclonal anti-Lyt-2/3 antibodies: parallel effects on cytolysis, proliferation and lymphokine secretion

Autor: H R MacDonald, Jean-Charles Cerottini, Andrew L. Glasebrook, Anne Kelso, Claude Bron, O. Acuto

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781468489613
Scopus-Elsevier

The interaction between cytolytic T lymphocytes (CTL) and target cells is presumed to be mediated by antigen-specific receptors on the surface of CTL. One approach to the identification and characterization of such putative receptors is thus to make

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e2fac191cde386bd251d19b77b24f5
https://ora.ox.ac.uk/objects/uuid:6451959d-6b58-4e7b-bd3a-5bdd3ea61ec7

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Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes

Autor: Danila Valmori, Pedro Romero, P. Rod Dunbar, Vincenzo Cerundolo, Graham S. Ogg, Jean-Charles Cerottini, Ji-Li Chen, Donata Rimoldi, Mikael J. Pittet, Danielle Liénard

Publikováno v: The Journal of Experimental Medicine

Characterization of cytolytic T lymphocyte (CTL) responses to tumor antigens has been impeded by a lack of direct assays of CTL activity. We have synthesized reagents (“tetramers”) that specifically stain CTLs recognizing melanoma antigens. Tetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bf893a3d60f9234c4a9bb143619f01
https://ora.ox.ac.uk/objects/uuid:6e063bda-0c58-4e89-abc1-97c4570ca193

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Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients

Autor: Hanifa Bouzourene, Gabriel Bricard, Jean Claude R Givel, Pedro M. S. Alves, Theres Fagerberg, Frédéric Lévy, Olivier Michielin, Henri Vuilleumier, Daniel E. Speiser, Sebastien Viatte, Pedro Romero, Thorsten Kruger, Jean Charles Cerottini

Publikováno v: Cancer immunology, immunotherapy, vol. 56, no. 11, pp. 1795-1805

Carcinoembryonic antigen (CEACAM5) is commonly overexpressed in human colon cancer. Several antigenic peptides recognized by cytolytic CD8+ T-cells have been identified and used in colon cancer phase-I vaccination clinical trials. The HLA-A*0201-bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca2bca08684f86ca0949ef4b4e3a580
https://doi.org/10.1007/s00262-007-0323-2

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Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor

Autor: Julie Tabiasco, Daniel E. Speiser, Estelle Devevre, Jean-Charles Cerottini, Pedro Romero, Nathalie Rufer, Bruno Salaun

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 177 (12), pp.8708-8713. ⟨10.4049/jimmunol.177.12.8708⟩
Journal of Immunology, 2006, 177 (12), pp.8708-8713. ⟨10.4049/jimmunol.177.12.8708⟩

TLR are evolutionarily conserved molecules that play a key role in the initiation of innate antimicrobial immune responses. Through their influence on dendritic cell maturation, these receptors are also thought to indirectly shape the adaptive immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07fa06b9bd61ae25a3168a41ee71321
https://doi.org/10.4049/jimmunol.177.12.8708

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New Generation Vaccine Induces Effective Melanoma-Specific CD8+ T Cells in the Circulation but Not in the Tumor Site

Autor: Severine Reynard, Pedro Romero, Danielle Liénard, Donata Rimoldi, Nathalie Rufer, Serge Leyvraz, Camilla Jandus, Jean Charles Cerottini, Philippe Guillaume, Sarah E. Coupland, Daniel E. Speiser, Victor Appay, Verena Voelter, Arthur M. Krieg

Publikováno v: The Journal of Immunology. 177:1670-1678

Although increasing evidence suggests that CTL are important to fight the development of some cancers, the frequency of detectable tumor-specific T cells is low in cancer patients, and these cells have generally poor functional capacities, compared w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5677ff5407f708f2fcb8bdcdc972c8
https://doi.org/10.4049/jimmunol.177.3.1670

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Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide

Autor: Catherine Barbey, Clemencia Pinilla, Victor Appay, Severine Reynard, Serge Leyvraz, Pedro Romero, Nathalie Rufer, Jean-Charles Cerottini, Daniel E. Speiser

Publikováno v: European Journal of Immunology. 36:1805-1814

The aim of T cell vaccines is the expansion of antigen-specific T cells able to confer immune protection against pathogens or tumors. Although increase in absolute cell numbers, effector functions and TCR repertoire of vaccine-induced T cells are oft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c681644f17089a694b94b73cf956fb
https://doi.org/10.1002/eji.200535805

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Ex Vivo Characterization of Allo-MHC-Restricted T Cells Specific for a Single MHC-Peptide Complex

Autor: Pedro Romero, Jean-Charles Cerottini, Frederic-Anne Le Gal, Pierre-Yves Dietrich, Asma Gati, Gilles Bioley, Alfred Zippelius, Daniel E. Speiser, Mikael J. Pittet, Magda De Smedt, Philippe Guillaume, Jean Plum

Publikováno v: The Journal of Immunology. 176:2330-2336

Alloreactive T cells are thought to be a potentially rich source of high-avidity T cells with therapeutic potential since tolerance to self-Ags is restricted to self-MHC recognition. Given the particularly high frequency of alloreactive T cells in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b370a4181f1789f03454e74d49cfc84
https://doi.org/10.4049/jimmunol.176.4.2330

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