Výsledky vyhledávání - "Jean-Cédric Frison"

3-Fluoro- and 3,3-Difluoro-3,4-dideoxy-KRN7000 Analogues as New Potent Immunostimulator Agents: Total Synthesis and Biological Evaluation in Human Invariant Natural Killer T Cells and Mice

Autor: J.Y. Douillard, Christine Saluzzo, Stéphane Guillarme, Gilles Dujardin, Séverine Marionneau-Lambot, Jézabel Rocher, Jacques Le Pendu, Jean-Yves Le Questel, Michel Evain, Jacques Lebreton, Jean-Cédric Frison, Didier Dubreuil, Mette Diswall, Muriel Pipelier, Thibauld Oullier, Denis Jacquemin, Jérôme Graton, Julie Hunault, Virginie Blot

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (3), pp.1227-1241. ⟨10.1021/jm201368m⟩

We propose here the synthesis and biological evaluation of 3,4-dideoxy-GalCer derivatives. The absence of the 3- and 4-hydroxyls on the sphingoid base is combined with the introduction of mono or difluoro substituent at C3 (analogues 8 and 9, respect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f556f1ec2e2dbc55f525dbb4debb45f0
https://doi.org/10.1021/jm201368m

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Synthesis and Structural Variation of Iron, Rhodium, Palladium, and Silver Complexes of a Chiral N-Heterocyclic Carbene−Phenoxyimine Hybrid Ligand

Autor: Stevan Simonovic, Gavin Dyson, Adrian C. Whitwood, Jean-Cédric Frison, Richard E. Douthwaite

Publikováno v: Organometallics. 27:281-288

A new class of chiral N-heterocyclic carbene (NHC) precursors has been prepared incorporating a phenoxyimine moiety. Reaction between 3-((1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxyphenyl)meth-(E)-ylidene]amino}cyclohexyl)-1-isopropyl-4-phenyl-3H-imida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf8b9d3bef6bdc3b5a1b15ed9567bc34
https://doi.org/10.1021/om7009478

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Ligand effects in aluminium-catalyzed asymmetric Baeyer–Villiger reactions

Autor: Chiara Palazzi, Jean-Cédric Frison, Carsten Bolm

Publikováno v: Tetrahedron. 62:6700-6706

Asymmetric Baeyer–Villiger oxidations of racemic and prochiral cyclobutanones can be performed with chiral aluminium-based Lewis acids resulting in products with good enantioselectivities in high yields. By employing substituted BINOL derivatives a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0aefab460b5ba022623d6765459cb72e
https://doi.org/10.1016/j.tet.2005.12.080

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Addition of N-Heterocyclic Carbenes to Imines: Phenoxide Assisted Deprotonation of an Imidazolium Moiety and Generation of Breslow Intermediates Derived from Imines

Autor: Hasan Koyuncu, Jean-Cédric Frison, Adrian C. Whitwood, Richard E. Douthwaite, Stevan Simonovic

Publikováno v: Organic Letters. 11:245-247

Reactions between imidazolium-imine salts and base result in C-C bond formation via intermediate N-heterocyclic carbenes. In the presence of a proximal OH moiety, carbene formation occurs via intramolecular deprotonation by phenoxide. For simple imin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a741f49d6b555cd62c3a5b29285166f
https://doi.org/10.1021/ol802572n

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Synthesis of chiral 2,2′-dipyridylamines and their use in the copper-catalyzed asymmetric allylic oxidation of cyclohexene

Autor: Jean-Cédric Frison, Christian Moessner, Carsten Bolm, Jacques Le Paih

Publikováno v: Tetrahedron Letters. 45:5019-5021

Chiral dipyridylamines have been synthesized by N-arylation reactions, and the applicability of those compounds to the copper-catalyzed asymmetric allylic oxidation of cyclohexene was demonstrated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4bcfcbbabb773c56a34d13433a2548
https://doi.org/10.1016/j.tetlet.2004.05.006

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Synthesis of C2-Symmetric and Unsymmetrically Substituted 2,2?-Dipyridylamines and Crystal Structure of a Chiral 2,2?-Dipyridylamine Copper(II) Complex

Autor: Jean-Cédric Frison, Carsten Bolm, Jacques Le Paih, Christian Moessner, Gerhard Raabe

Publikováno v: ChemInform. 36

C2-symmetric and unsymmetrically substituted 2,2′-dipyridylamines have been synthesized by sequential Buchwald–Hartwig aminations of halo-pyridines. The X-ray crystal structure of a copper dichloride complex bearing a C2-symmetric 2,2′-dipyridy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473cb26de50de6eba8e045a264a51bbb
https://doi.org/10.1002/chin.200512038

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Vaulted Biaryls: Efficient Ligands for the Aluminum-Catalyzed Asymmetric Baeyer—Villiger Reaction

Autor: Yu Zhang, William D. Wulff, Carsten Bolm, Jean-Cédric Frison

Publikováno v: ChemInform. 35

Vaulted biaryls (VANOL and VAPOL) have been ap- plied in the aluminum-catalyzed asymmetric Baeyer-Villiger reaction of prochiral 3-substituted cyclobutanones. Optically active g-butyrolactones are obtained in high yields with enantioselectivi- ties o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fbc1e37a6ba717179404bad2400e980
https://doi.org/10.1002/chin.200447024

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Synthesis of rhodium(I) and iridium(I) complexes of chiral N-heterocyclic carbenes and their application to asymmetric transfer hydrogenation

Autor: Gavin Dyson, Richard E. Douthwaite, Adrian C. Whitwood, Jean-Cédric Frison

Publikováno v: Dalton Transactions. :7141

Rhodium and iridium complexes of chiral NHC-phenolimine and NHC-amine ligands have been prepared and studied for asymmetric transfer hydrogenation. X-ray and NMR spectroscopy show that for NHC-phenolimine complexes abstraction of chloride results in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940fd4f92801ffb2aedf9b7f526271fb
https://doi.org/10.1039/b909290k

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