Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jean-Baptiste Pérot"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Huntington’s disease is an inherited disorder characterized by psychiatric, cognitive, and motor symptoms due to degeneration of medium spiny neurons in the striatum. A prodromal phase precedes the onset, lasting decades. Current biomarkers include
Externí odkaz:
https://doaj.org/article/58f45c2b56ae4279a7aab55ce01f7769
Autor:
Jean-Baptiste Pérot, Anna Niewiadomska-Cimicka, Emmanuel Brouillet, Yvon Trottier, Julien Flament
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/06d375aa85d2492a84114e10af070394
Autor:
Elsa C. Kuijper, Maurice Overzier, Ernst Suidgeest, Oleh Dzyubachyk, Cécile Maguin, Jean-Baptiste Pérot, Julien Flament, Yavuz Ariyurek, Hailiang Mei, Ronald A.M. Buijsen, Louise van der Weerd, Willeke van Roon-Mom
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106368- (2024)
In Huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated from the mutant huntingtin (HTT) protein. By modifying the HTT protein, we aim to reduce proteolytic cleavage and ameliorate the consequences of muta
Externí odkaz:
https://doaj.org/article/0b4874be3df4497fb539494749184266
Autor:
Kalina Wiatr, Łukasz Marczak, Jean-Baptiste Pérot, Emmanuel Brouillet, Julien Flament, Maciej Figiel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Spinocerebellar ataxia type 3 (SCA3/MJD) is caused by CAG expansion mutation resulting in a long polyQ domain in mutant ataxin-3. The mutant protein is a special type of protease, deubiquitinase, which may indicate its prominent impact on the regulat
Externí odkaz:
https://doaj.org/article/7a4c91f909c24f0e9962e82f252ab731
Autor:
Celine Baligand, Olivier Barret, Amélie Tourais, Jean-Baptiste Pérot, Didier Thenadey, Fanny Petit, Géraldine Liot, Marie-Claude Gaillard, Julien Flament, Marc Dhenain, Julien Valette
Publikováno v:
Metabolites, Vol 11, Iss 5, p 263 (2021)
The cerebral metabolic rate of oxygen consumption (CMRO2) is a key metric to investigate the mechanisms involved in neurodegeneration in animal models and evaluate potential new therapies. CMRO2 can be measured by direct 17O magnetic resonance imagin
Externí odkaz:
https://doaj.org/article/9800fa1b3c1a45afbcaa54a6b0517ae2
Autor:
Jean-Baptiste Pérot, Marc Dhenain, Sandrine Humbert, Emmanuel Brouillet, Julien Flament, Marina Celestine
Publikováno v:
A: Pathogenic mechanisms.
Purpose Pathogenesis of Huntington’s Disease (HD) is complex and progressive. Subtle changes seem to occur in the brain of gene carriers far from the onset of symptoms.1 There is a need of early, functional biomarkers, for pathogenesis understandin
Autor:
Jean-Baptiste Pérot, Marina Célestine, Marco Palombo, Marc Dhenain, Sandrine Humbert, Emmanuel Brouillet, Julien Flament
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, 2022, ⟨10.1093/hmg/ddac036⟩
Human Molecular Genetics, 2022, ⟨10.1093/hmg/ddac036⟩
Pathogenesis of the inherited neurodegenerative disorder Huntington’s disease (HD) is progressive with a long presymptomatic phase in which subtle changes occur up to 15 years before the onset of symptoms. Thus, there is a need for early, functiona
Autor:
Géraldine Liot, Marc Dhenain, Amélie Tourais, Celine Baligand, Marie-Claude Gaillard, Jean-Baptiste Pérot, Fanny Petit, Olivier Barret, Julien Flament, Didier Thenadey, Julien Valette
Publikováno v:
Metabolites
Metabolites, MDPI, 2021, 11 (5), pp.263. ⟨10.3390/metabo11050263⟩
Metabolites, Vol 11, Iss 263, p 263 (2021)
Volume 11
Issue 5
Metabolites, 2021, 11 (5), pp.263. ⟨10.3390/metabo11050263⟩
Metabolites, MDPI, 2021, 11 (5), pp.263. ⟨10.3390/metabo11050263⟩
Metabolites, Vol 11, Iss 263, p 263 (2021)
Volume 11
Issue 5
Metabolites, 2021, 11 (5), pp.263. ⟨10.3390/metabo11050263⟩
The cerebral metabolic rate of oxygen consumption (CMRO2) is a key metric to investigate the mechanisms involved in neurodegeneration in animal models and evaluate potential new therapies. CMRO2 can be measured by direct 17O magnetic resonance imagin
Autor:
Marina Célestine, Muriel Jacquier-Sarlin, Eve Borel, Fanny Petit, Jean-Baptiste Perot, Anne-Sophie Hérard, Luc Bousset, Alain Buisson, Marc Dhenain
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Alzheimer’s disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins induce synaptic dysfunctions that are strongly correl
Externí odkaz:
https://doaj.org/article/8307e6636dd947a5bdd092741308d2d4