Výsledky vyhledávání - "Jean-Baptiste Garsi"

Akademický článek

Ni-Catalyzed Reductive and Merged Photocatalytic Cross-Coupling Reactions toward sp3/sp2‑Functionalized Isoquinolones: Creating Diversity at C‑6 and C‑7 to Address Bioactive Analogues

Autor: Adrien Dumas, Jean-Baptiste Garsi, Guillaume Poissonnet, Stephen Hanessian

Publikováno v: ACS Omega, Vol 5, Iss 42, Pp 27591-27606 (2020)

Externí odkaz: https://doaj.org/article/2236469ca48441e6a2f6f5ef289bfa52

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Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics

Autor: Jean-Baptiste Garsi, Balázs Komjáti, Gregorio Cullia, Imre Fejes, Melinda Sipos, Zoltán Sipos, Eszter Fördős, Piroska Markacz, Barbara Balázs, Nathalie Lancelot, Sylvie Berger, Eric Raimbaud, David Brown, Laurent-Michel Vuillard, Laure Haberkorn, Cyprian Cukier, Zoltán Szlávik, Stephen Hanessian

Publikováno v: ACS medicinal chemistry letters, vol 13, iss 6
ACS Med Chem Lett

[Image: see text] On the basis of the knowledge that the proline-rich hot spot PPPRPP region of P(151)PSNPPPRPP(160), an oligopeptide derived from the cytosolic portion of p22(phox) (p22), binds to the single functional bis-SH3 domain of the regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa70b14a5bdfbbdfe94d8e9fe7ef2af
https://doi.org/10.1021/acsmedchemlett.2c00094

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2-Oxa-5-azabicyclo[2.2.1]heptane as a Platform for Functional Diversity: Synthesis of Backbone-Constrained γ-Amino Acid Analogues

Autor: Jean-Baptiste Garsi, Solène Guggari, Thomas Deis, Myles Ma, Sofiane Hocine, Stephen Hanessian

Publikováno v: The Journal of organic chemistry. 87(16)

We communicate a versatile synthetic approach to C-3 disubstituted 2-oxa-5-azabicyclo[2.2.1]heptanes as carbon-atom bridged morpholines, starting with 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c717b7b0d904588a41fc74f8e1cea1fd
https://pubmed.ncbi.nlm.nih.gov/35900070

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Design of Pseudodiproline Dimers as Mimetics of Pro-Pro Units: Stereocontrolled Synthesis, Configurational Relevance, and Structural Properties

Autor: Stephen Hanessian, Jean-Baptiste Garsi, Pedro Aguiar

Publikováno v: The Journal of organic chemistry. 86(23)

Stereocontrolled methods are described for the synthesis of hitherto unreported pseudodiproline dimers in which a cyclopentane carboxylic acid is linked to a pyrrolidine residue by a stereochemically defined hydroxymethylene tether. These proline-cyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea706f8a8343b1ce31c86f6b7a5aa7b
https://pubmed.ncbi.nlm.nih.gov/34749500

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Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A

Autor: Lorenzo Sernissi, Vito Vece, Aimee L. Edinger, Nadine Ben Romdhane, Stephen Hanessian, Amogha Dahal, Alison N. McCracken, Cuauhtemoc Ramirez, Catherine Auger-Morin, Jean-Baptiste Garsi, Brendan T. Finicle, Elizabeth Selwan

Publikováno v: Bioorg Med Chem Lett

Inspired by the cytotoxicity of perphenazine toward cancer cells and its ability to activate the serine/threonine protein phosphatase 2A (PP2A), we prepared series of ether-carbon linked analogs of a constrained synthetic sphingolipid analog 3, known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e269fea4105632dbc442061c4ce12bc
https://pubmed.ncbi.nlm.nih.gov/31383588

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In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways

Autor: Grigor S. Simitian, Jean-Baptiste Garsi, Stephen Hanessian, Aimee L. Edinger, Vito Vece, Lorenzo Sernissi, Alison N. McCracken

A series of compounds containing pyrrolidine and pyrrolizidine cores with appended hydrophobic substituents were prepared as constrained analogs of FTY720 and phytosphingosine. The effect of these compounds on the viability of cancer cells, on downre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa651aff0ba68cc91e08896155f79e4
https://europepmc.org/articles/PMC6217821/

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Synthesis of 1,2-Dihydropyridines Catalyzed by Well-Defined Low-Valent Cobalt Complexes: C-H Activation Made Simple

Autor: Marc Petit, Jean-Baptiste Garsi, Etienne Derat, Brendan J. Fallon, Corinne Aubert, Muriel Amatore

Publikováno v: ACS Catalysis
ACS Catalysis, 2015, 5 (12), pp.7493-7497. ⟨10.1021/acscatal.5b02138⟩
ACS Catalysis, American Chemical Society, 2015, 5 (12), pp.7493-7497. ⟨10.1021/acscatal.5b02138⟩

International audience; A convenient one-pot system has been developed, allowing the synthesis of highly substituted dihydropyridines via a C-H activation/6 pi-electrocyclization pathway. The reaction proceeds with high regioselectivity, and we discl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40441d9ce785b4869a3a3d54b913ab21
https://hal.science/hal-01397966

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