Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Jean-Alain Fehrentz"'
Autor:
Brigida Boccanegra, Ornella Cappellari, Paola Mantuano, Daniela Trisciuzzi, Antonietta Mele, Lisamaura Tulimiero, Michela De Bellis, Santa Cirmi, Francesca Sanarica, Alessandro Giovanni Cerchiara, Elena Conte, Ramona Meanti, Laura Rizzi, Elena Bresciani, Severine Denoyelle, Jean-Alain Fehrentz, Gabriele Cruciani, Orazio Nicolotti, Antonella Liantonio, Antonio Torsello, Annamaria De Luca
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionGrowth hormone secretagogues (GHSs) exert multiple actions, being able to activate GHS-receptor 1a, control inflammation and metabolism, to enhance GH/insulin-like growth factor-1 (IGF-1)-mediated myogenesis, and to inhibit angiotensin-co
Externí odkaz:
https://doaj.org/article/d37929ca58e6446b9eba622262e2222e
Autor:
Marjorie Damian, Maxime Louet, Antoniel Augusto Severo Gomes, Céline M’Kadmi, Séverine Denoyelle, Sonia Cantel, Sophie Mary, Paulo M. Bisch, Jean-Alain Fehrentz, Laurent J. Catoire, Nicolas Floquet, Jean-Louis Banères
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here authors demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effe
Externí odkaz:
https://doaj.org/article/2ff1774b14b842c1ba2707a2e704a84a
Autor:
Maxime Louet, Marina Casiraghi, Marjorie Damian, Mauricio GS Costa, Pedro Renault, Antoniel AS Gomes, Paulo R Batista, Céline M'Kadmi, Sophie Mary, Sonia Cantel, Severine Denoyelle, Khoubaib Ben Haj Salah, David Perahia, Paulo M Bisch, Jean-Alain Fehrentz, Laurent J Catoire, Nicolas Floquet, Jean-Louis Banères
Publikováno v:
eLife, Vol 10 (2021)
There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy. Here, we combined site-specific labelin
Externí odkaz:
https://doaj.org/article/0314baab73134fab94c1e7b73579cdc2
Autor:
Emilio R. Mustafá, Santiago Cordisco González, Marjorie Damian, Sonia Cantel, Severine Denoyelle, Renaud Wagner, Helgi B. Schiöth, Jean-Alain Fehrentz, Jean-Louis Banères, Mario Perelló, Jesica Raingo
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2
Externí odkaz:
https://doaj.org/article/0e77ad9215a246d98475647b715d366f
Autor:
Elia A. Turolla, Silvia Valtorta, Elena Bresciani, Jean-Alain Fehrentz, Liliana Giuliano, Stefano Stucchi, Sara Belloli, Paolo Rainone, Francesco Sudati, Laura Rizzi, Laura Molteni, Pascal Verdiè, Jean Martinez, Antonio Torsello, Rosa Maria Moresco, Sergio Todde
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
TLQP-21 is a neuropeptide that is involved in the control of several physiological functions, including energy homeostasis. Since TLQP-21 could oppose the early phase of diet-induced obesity, it has raised a huge interest, but very little is known ab
Externí odkaz:
https://doaj.org/article/afa2f17ce9474be788a42c8b8f2003e9
Autor:
Laura Molteni, Laura Rizzi, Elena Bresciani, Ramona Meanti, Jean-Alain Fehrentz, Pascal Verdié, Robert J. Omeljaniuk, Giuseppe Biagini, Vittorio Locatelli, Antonio Torsello
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
TLQP-21 is a neuropeptide which has been implicated in regulation of nociception and other relevant physiologic functions. Although recent studies identified C3a and gC1q receptors as targets for TLQP-21, its intracellular molecular mechanisms of act
Externí odkaz:
https://doaj.org/article/ae5d07f7250f41b992e2f9b32492904a
Autor:
Chiara Lucchi, Anna M. Costa, Carmela Giordano, Giulia Curia, Marika Piat, Giuseppina Leo, Jonathan Vinet, Luc Brunel, Jean-Alain Fehrentz, Jean Martinez, Antonio Torsello, Giuseppe Biagini
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Ghrelin, des-acyl ghrelin and other related peptides possess anticonvulsant activities. Although ghrelin and cognate peptides were shown to physiologically regulate only the ghrelin receptor, some of them were pharmacologically proved to activate the
Externí odkaz:
https://doaj.org/article/8891337d3594475288037daa3605b95b
Autor:
Carmela Giordano, Anna M Costa, Chiara Lucchi, Giuseppina Leo, Luc Brunel, Jean-Alain Fehrentz, JEAN MARTINEZ, Antonio Torsello, Giuseppe Biagini
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
The 6-Hz corneal stimulation test is used to screen novel antiepileptic molecules to overcome the problem of drug refractoriness. Although recognized as a standard test, it has been evaluated only recently in the attempt to characterize the putative
Externí odkaz:
https://doaj.org/article/3834961fc4474fddad08d62c5a9e2481
Autor:
An Buckinx, Yana Van Den Herrewegen, Anouk Pierre, Eleonora Cottone, Khoubaib Ben Haj Salah, Jean-Alain Fehrentz, Ron Kooijman, Dimitri De Bundel, Ilse Smolders
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2480 (2019)
The ghrelin system has received substantial recognition as a potential target for novel anti-seizure drugs. Ghrelin receptor (ghrelin-R) signaling is complex, involving Gαq/11, Gαi/o, Gα12/13, and β-arrestin pathways. In this study, we aimed to d
Externí odkaz:
https://doaj.org/article/148c076afa6842b0927088e4fb29025c
Autor:
Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9159 (2010)
BACKGROUND:Ghrelin targets the arcuate nucleus, from where growth hormone releasing hormone (GHRH) neurones trigger GH secretion. This hypothalamic nucleus also contains neuropeptide Y (NPY) neurons which play a master role in the effect of ghrelin o
Externí odkaz:
https://doaj.org/article/5627aeb44d88436599b6fd6826f457a7