Zobrazeno 1 - 10
of 564
pro vyhledávání: '"Jean-A. Boutin"'
Autor:
Elzbieta Janda, Maddalena Parafati, Concetta Martino, Francesco Crupi, Jonahunnatha Nesson George William, Karine Reybier, Mariamena Arbitrio, Vincenzo Mollace, Jean A. Boutin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Dopaminergic degeneration is a central feature of Parkinson’s disease (PD), but glial dysfunction may accelerate or trigger neuronal death. In fact, astrocytes play a key role in the maintenance of the blood–brain barrier and detoxificat
Externí odkaz:
https://doaj.org/article/305e79949fbd4fa1a4b957c1e363caa3
Autor:
Amine Bourzam, Yosra Hamdi, Seyma Bahdoudi, Karthi Duraisamy, Mouna El Mehdi, Magali Basille-Dugay, Omayma Dlimi, Maher Kharrat, Anne Vejux, Gérard Lizard, Taoufik Ghrairi, Benjamin Lefranc, David Vaudry, Jean A. Boutin, Jérôme Leprince, Olfa Masmoudi-Kouki
Publikováno v:
Cells, Vol 13, Iss 14, p 1188 (2024)
Astrocytes specifically synthesize and release endozepines, a family of regulatory peptides including octadecaneuropeptide (ODN). We have previously reported that ODN rescues neurons and astrocytes from 6-OHDA-induced oxidative stress and cell death.
Externí odkaz:
https://doaj.org/article/c4fff4d4ea234ecb9224171425bc6f6e
Autor:
Juliette Gueguen, Marc‐Olivier Timsit, Anne Scemla, Jean‐Michel Boutin, Franck Bruyere, Hélène Longuet, Rebecca Sberro‐Soussan, Christophe Legendre, Dany Anglicheau, Matthias Büchler
Publikováno v:
BJUI Compass, Vol 3, Iss 1, Pp 75-85 (2022)
Abstract Background Due to increased risk of pyelonephritis, patients with intestinal reconstruction of the lower urinary tract (IRLUT) have long been advised against kidney transplantation. The aim of this study was to compare the outcomes of transp
Externí odkaz:
https://doaj.org/article/a48423548e324bc29fc6480abe6a5817
Autor:
Paulo W.P. Gomes, Thaiana C.D.L. Pamplona, Kely C. Navegantes-Lima, Lucas B.G. Quadros, Ana L.B. Oliveira, Sávio M. Santos, Consuelo Y.Y. e Silva, Maria J.C. Silva, Jesus N.S. Souza, Luis M. Quirós-Guerrero, Jean A. Boutin, Marta C. Monteiro, Milton N. da Silva
Publikováno v:
Arabian Journal of Chemistry, Vol 14, Iss 6, Pp 103183- (2021)
Stryphnodendron pulcherrimum (Willd.) Hochr. (Fabaceae) is a native Amazonian tree, popularly known as “barbatimão”. The stem barks of this tree are widely used in folk medicine to treat infections, cutaneous and ulcerative wounds, under the for
Externí odkaz:
https://doaj.org/article/f924e93afa0b42258d120923aa9dba12
Autor:
Monivan Chhour, Pierre Perio, Regis Gayon, Hélène Ternet-Fontebasso, Gilles Ferry, Françoise Nepveu, Jean A. Boutin, Jan Sudor, Karine Reybier
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The balance between detoxification and toxicity is linked to enzymes of the drug metabolism Phase I (cytochrome P450 or oxidoreductases) and phase II conjugating enzymes (such as the UGTs). After the reduction of quinones, the product of the reaction
Externí odkaz:
https://doaj.org/article/26bc792e0c0542f4b230c4e3914b1c67
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The screening and testing of extracts against a variety of pharmacological targets in order to benefit from the immense natural chemical diversity is a concern in many laboratories worldwide. And several successes have been recorded in finding new ac
Externí odkaz:
https://doaj.org/article/77eed5940f134010b1a53ddd0e4dba64
Autor:
Jean A. Boutin, Céline Legros
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract Receptology has been complicated with enhancements in our knowledge of G‐protein‐coupled‐receptor (GPCR) biochemistry. This complexity is exemplified by the pharmacology of melatonin receptors. Here, we describe the complexity of GPCR
Externí odkaz:
https://doaj.org/article/79c59ac6169e44b39512559e491472d6
Autor:
Céline Legros, Clémence Dupré, Chantal Brasseur, Anne Bonnaud, Olivier Bruno, Damien Valour, Preety Shabajee, Adeline Giganti, Olivier Nosjean, Terrence P. Kenakin, Jean A. Boutin
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract Melatonin is a neurohormone that translates the circadian rhythm to the peripheral organs through a series of binding sites identified as G protein‐coupled receptors MT1 and MT2. Due to minute amounts of receptor proteins in target organs,
Externí odkaz:
https://doaj.org/article/08643ceb060e4077bb6c6bb5129fe136
Autor:
Jérôme Leprince, Jean Albert Boutin
Publikováno v:
Receptors. 2:16-33
Intuitively, it is easy to understand why we search for G protein-coupled receptor (GPCR) antagonists. It is obviously to block a functionality of a specific receptor potentially linked to some aspects of disease. Whether by focused research or by se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7a4226ed50a5ded67f79a7b1fde493e
https://doi.org/10.3390/receptors2010002
https://doi.org/10.3390/receptors2010002
Autor:
Lucie Vasseur, Alain Chavanieu, Stéphanie Combemale, Cécile Caumes, Rémy Béroud, Michel De Waard, Pierre Ducrot, Jean A. Boutin, Gilles Ferry, Thierry Cens
Publikováno v:
Toxicon: X, Vol 2, Iss , Pp - (2019)
Peptidic toxins that target specifically mammalian channels and receptors can be found in the venom of animals. These toxins are rarely used directly as tools for biochemical experiments, and need to be modified via the attachment of chemical groups
Externí odkaz:
https://doaj.org/article/d7deb9525faa4eb18f47c1f192f89068