Zobrazeno 1 - 10
of 610
pro vyhledávání: '"Jean- Pierre Routy"'
Autor:
Luling Wu, Zhihang Zheng, Jingna Xun, Li Liu, Jiangrong Wang, Xinyu Zhang, Yueming Shao, Yinzhong Shen, Renfang Zhang, Min Zhang, Meiyan Sun, Tangkai Qi, Zhenyan Wang, Shuibao Xu, Wei Song, Yang Tang, Bihe Zhao, Zichen Song, Jean-Pierre Routy, Hongzhou Lu, Jun Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract The combination of ASC22, an anti-PD-L1 antibody potentially enhancing HIV-specific immunity and chidamide, a HIV latency reversal agent, may serve as a strategy for antiretroviral therapy-free virological control for HIV. People living with
Externí odkaz:
https://doaj.org/article/842e488f954247f1a02a9c89c283bae1
Autor:
Anish K. Arora, Serge Vicente, Kim Engler, David Lessard, Edmundo Huerta, Joel Ishak, Nadine Kronfli, Jean-Pierre Routy, Joseph Cox, Benoit Lemire, Marina Klein, Alexandra de Pokomandy, Lina Del Balso, Giada Sebastiani, Isabelle Vedel, Amélie Quesnel-Vallée, Bertrand Lebouché, ASAP Migrant Advisory Committee
Publikováno v:
AIDS Research and Therapy, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background Scholars recommend providing migrants living with HIV (MLWH) with free treatment, rapidly, once linked to care to optimize their HIV-related experiences and health outcomes. Quantitative evaluations of patient-reported measures fo
Externí odkaz:
https://doaj.org/article/ee4b34e3011845129d52702400ea36ef
Autor:
Alexis Yero, Jean-Philippe Goulet, Tao Shi, Cecilia T. Costiniuk, Jean-Pierre Routy, Cecile Tremblay, Ralph-Sydney Mboumba Bouassa, Yulia Alexandrova, Amélie Pagliuzza, Nicolas Chomont, Petronela Ancuta, Mohammad-Ali Jenabian
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105274- (2024)
Summary: Background: Despite successful antiretroviral therapy (ART), frequencies and immunological functions of memory CCR6+ Th17-polarised CD4+ T-cells are not fully restored in people with HIV (PWH). Moreover, long-lived Th17 cells contribute to H
Externí odkaz:
https://doaj.org/article/ca111586e7a54db389f6a611caef3faa
Autor:
Augustine Fert, Jonathan Richard, Laurence Raymond Marchand, Delphine Planas, Jean-Pierre Routy, Nicolas Chomont, Andrés Finzi, Petronela Ancuta
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110670- (2024)
Summary: The mechanistic target of rapamycin (mTOR) positively regulates multiple steps of the HIV-1 replication cycle. We previously reported that a 12-week supplementation of antiretroviral therapy (ART) with metformin, an indirect mTOR inhibitor u
Externí odkaz:
https://doaj.org/article/f0e7023e3226433cba971be540ffd895
Autor:
Kim Doyon-Laliberté, Matheus Aranguren, Josiane Chagnon-Choquet, Laurie-Anne Batraville, Olina Dagher, Jonathan Richard, Matteo Paniconi, Jean-Pierre Routy, Cécile Tremblay, Marie-Claude Quintal, Nathalie Brassard, Daniel E. Kaufmann, Andrés Finzi, Johanne Poudrier, Michel Roger
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 25-43 (2023)
We have previously shown that blood levels of B-cell Activating Factor (BAFF) rise relatively to disease progression status in the context of HIV-1 infection. Excess BAFF was concomitant with hyperglobulinemia and the deregulation of blood B-cell pop
Externí odkaz:
https://doaj.org/article/c20c0e25dc9b4e00a5969e51c9f62b7e
Autor:
Alexis Yero, Tao Shi, Julien A. Clain, Ouafa Zghidi-Abouzid, Gina Racine, Cecilia T. Costiniuk, Jean-Pierre Routy, Jérôme Estaquier, Mohammad-Ali Jenabian
Publikováno v:
Viruses, Vol 16, Iss 10, p 1609 (2024)
HIV infection significantly affects the frequencies and functions of immunoregulatory CD3+CD4−CD8− double-negative (DN) T-cells, while the effect of early antiretroviral therapy (ART) initiation on these cells remains understudied. DN T-cell subs
Externí odkaz:
https://doaj.org/article/ae57dd0368cc415c972bb1891580decd
Autor:
Simeng Bu, Léna Royston, Tsoarello Mabanga, Carolina A. Berini, Cécile Tremblay, Bertrand Lebouché, Joseph Cox, Cecilia T. Costiniuk, Madeleine Durand, Stephane Isnard, Jean-Pierre Routy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionGrowth differentiation factor 15 (GDF-15) was originally described as a stress-induced cytokine, and a biomarker of aging and cardiovascular diseases. We hypothesized that circulating GDF-15 would be associated with COVID-19 disease sever
Externí odkaz:
https://doaj.org/article/118497c2a4684df6a727941e2a1e3d08
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Antiretroviral therapies (ART) have reduced human immunodeficiency virus (HIV) infection-associated morbidity and mortality improving the life of people with HIV (PWH). However, ART lead to residual HIV production, which in conjunction with microbial
Externí odkaz:
https://doaj.org/article/c50c17e266334c88bd692fccd5af56c8
Autor:
Clara Long, Abdulrahman Al-Abdulmalek, Jonathan Lai, David G. Haegert, Stephane Isnard, Denis Cournoyer, Jean-Pierre Routy
Publikováno v:
European Journal of Case Reports in Internal Medicine (2024)
Background: Autoimmune diseases are not contraindications for immune checkpoint inhibitors (ICI) therapy in patients with cancer. However, immune-related adverse events (irAEs) are frequently observed in patients receiving ICIs including dermatitis,
Externí odkaz:
https://doaj.org/article/462c6f2c25e1487f94983410b51227c1
Autor:
Maryam Nayyerabadi, Lyvia Fourcade, Swarali A. Joshi, Prabha Chandrasekaran, Arpita Chakravarti, Chantal Massé, Marie-Lorna Paul, Joanie Houle, Amina M. Boubekeur, Charlotte DuSablon, Valérie Boudreau, Danijela Bovan, Emma Darbinian, Emilia Aïsha Coleman, Sandra Vinci, Jean-Pierre Routy, Pierre-Olivier Hétu, Johanne Poudrier, Emilia Liana Falcone
Publikováno v:
International Journal of Infectious Diseases, Vol 136, Iss , Pp 136-145 (2023)
Background: Vaccination protects against severe COVID-19 manifestations. For those with post-COVID-19 conditions (PCC) or long COVID, the impact of COVID-19 vaccination on the evolution of symptoms, immune responses, and viral persistence is unclear.
Externí odkaz:
https://doaj.org/article/d74a1183418047bc9d8073d80f5b4e86